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Visualizing the Cost of Age-Related Disease as Disability Adjusted Life Years
Disability adjusted life years (DALYs) are a statistical construct used in epidemiology to assess the harms caused by disease, particularly the chronic diseases of aging, as these are by far the greatest burden of disease that is inflicted upon the population as a whole. The costs of aging are huge, however they are measured. It is the greatest single cause of human suffering and death, and the economic effects of this constant destruction of human lives and capabilities are sized to match. The greatest good any of us can do in the world as it stands today is to work towards bringing aging under medical control. D...
Source: Fight Aging! - April 17, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Out of Hospital Cardiac Arrest third leading cause of DALY
Disability Adjusted Life Years (DALY) following adult nontraumatic Out of Hospital Cardiac Arrest (OHCA) treated by Emergency Medical in the United States of America has been shown to be the third leading cause of DALY lost in the year 2016 [1]. DALY is a standardized public health measure for estimating and comparing the burden of disease to the society at large. Coute RA and associates used the data from US national Cardiac Arrest Registry to Enhance Survival database for 2016. Years of life lost was calculated from this data and the remaining life expectancy at the age of death. Cerebral performance category scores fr...
Source: Cardiophile MD - April 10, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

8 Things Autistic People Wished You Knew about April
Every April, autism takes a center stage in global awareness. All around the world, well-meaning, good-hearted people “Light it up blue” for Autism Awareness Month, and they decorate their social media with the puzzle piece frames and the jigsaw rainbow awareness ribbons. And, every March, autistic adults are already dreading April. Many of them report feeling traumatized by previous Aprils. They begin to mentally prepare for what is ahead, feeling powerless to stop it. They’re bracing themselves for what is on the horizon. What autistic people wish their neurotypical allies knew going into April: We really don’t...
Source: World of Psychology - April 8, 2019 Category: Psychiatry & Psychology Authors: Terra Vance Tags: Aspergers Autism General Personal Stigma Autism Acceptance Month Autism Awareness Month Autism Spectrum medical disability model neurodivergent neurodiversity neurotypical allies stereotyping Stigmatization Source Type: blogs

Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What Will Being Healthy Mean In The Future?
The objective is not “just” being healthy anymore but also being in the best shape possible. The healthy lifestyle craze that started in the 1980s is augmented with technologies and penetrates every area and moment of life. In his book, 21 Lessons for the 21st Century, Yuval Noah Harari argues that as technology encompasses every tiny part of our health, we will gradually let technology take over our decision-making capacities. In a couple of decades, tiny sensors and big data might tell us whether we are sick or healthy. Medical decisions in our life won’t rely on our feelings of illness or wellness, or even on t...
Source: The Medical Futurist - April 6, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence in Medicine Bioethics Health Sensors & Trackers AI doctor dystopia future Healthcare healthy healthy lifestyle history history of medicine Innovation patient philosophy progress technology Source Type: blogs

Low Mitochondrial Permeability is Required for Autophagy to Extend Life Span
Mitochondria are the power plants of the cell, generating the chemical energy store molecule adenosine triphosphate (ATP) that powers cellular processes. Every cell possesses a herd of mitochondria, replicating like bacteria, and monitored by quality control mechanisms. Damaged, potentially harmful mitochondria are removed and dismantled for raw materials through a variant of autophagy called mitophagy. A mountain of evidence links mitochondrial function to aging, just as a mountain of evidence links the cellular recycling mechanisms of autophagy to aging. Both mitochondrial function and autophagic activity decline with ag...
Source: Fight Aging! - April 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Simple Ways To Boost Health Care Access for People With Communication Disorders
The objectives—and perhaps even more interesting, the disparities within the objectives according to sex, educational attainment and disability status—are tracked by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics. We can search the CDC’s database by topic area for additional data on health care disparities. While the government works toward the Healthy People initiative, we can help improve health care access for those with communication disorders in our communities. I started by considering people’s social determinants of health in my community and surrounding areas....
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - March 25, 2019 Category: Speech-Language Pathology Authors: Shelley D. Hutchins Tags: Audiology Health Care Private Practice Slider Speech-Language Pathology hearing loss Language Disorders Speech Disorders Source Type: blogs

Fight Aging! Newsletter, March 25th 2019
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - March 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aspirin for primary prevention of cardiovascular disease, part 2
Update In March 2019, the American College of Cardiology (ACC) and the American Heart Association (AHA) released new guidelines that suggest that most adults without a history of heart disease should not take low-dose daily aspirin to prevent a first heart attack or stroke. Based on the ASPREE, ARRIVE, and ASCEND trials, the ACC/AHA guidelines concluded that the risk of side effects from aspirin, particularly bleeding, outweighed the potential benefit. The new guidelines do not pertain to people with established cardiovascular disease, in whom the benefits of daily aspirin have been found to outweigh the risks. ___________...
Source: Harvard Health Blog - March 14, 2019 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs

Podcast: Talking Suicide with a Bipolar and a Schizophrenic
 Suicide is something that most people think they understand, but there are many misconceptions about it. We say it’s a serious problem, yet will mention it casually and insensitively in certain settings. In this episode, our hosts openly discuss suicide and their personal stories with trying to end their own lives.   SUBSCRIBE & REVIEW “I thought about suicide every day for as far back as I can remember.” – Gabe Howard   Highlights From ‘Suicide’ Episode [1:00] Frankly discussing suicide. [3:00] Don’t belittle a person’s suicide attempt. [7:00] Why did Michelle try to end her...
Source: World of Psychology - March 11, 2019 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Schizophrenia Suicide Source Type: blogs

Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Language Matters: You Are Not an Illness
A person should not be defined by an illness or condition.  Often in popular media or casual conversation, people speak about the subject of a news story or an acquaintance by saying, “he is bipolar”, “schizophrenic”, or “mentally ill.” No one says, “She is cancer,” “she is a heart condition,” or “she is lupus.” Aside from a few very select common physical illnesses, such as diabetes where people find community and comfort in sharing their diagnosis, we would never consider insulting a person by simply identifying them by the disease which they have endured o...
Source: World of Psychology - February 28, 2019 Category: Psychiatry & Psychology Authors: Colleen Donnelly Tags: General Mental Health and Wellness Minding the Media Stigma Crisis Counseling destigmatization discrimination Labels neurodivergent Stereotypes Validation Source Type: blogs

Fight Aging! Newsletter, February 11th 2019
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Arguing that Public Desire for Greater Longevity is Growing
Our community has undertaken years of advocacy for rejuvenation research, with the aim of developing ways to reverse age-related disease and disability, and thus greatly extend healthy life spans. The first concrete results are emerging from the research community, the result of philanthropy and persuasion, then the incremental accretion of funding to programs that showed promising initial data. So now we have senolytics, and I would hope not too many years from now we'll have glucosepane cross-link breakers - and then more thereafter. But have we persuaded the broader public at all? Have we convinced more than a sm...
Source: Fight Aging! - February 5, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs