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Fight Aging! Newsletter, October 8th 2018
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - October 7, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aspirin for primary prevention of cardiovascular disease, part 2
Well, it seems as though not even a week can go by without more data on aspirin! I recently reviewed the ARRIVE trial and the implications for primary prevention — that is, trying to prevent heart attacks and strokes in otherwise healthy people. Since then, yet another large clinical trial — the ASPREE study — has come out questioning the use of aspirin in primary prevention. Three articles pertaining to this trial were published in the prestigious New England Journal of Medicine, which is an unusual degree of coverage for one trial and highlights its immediate relevance to clinical practice.
Aspirin still strongly i...
Source: Harvard Health Blog - September 25, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs
Alcohol and your health: Is none better than a little?
It’s complicated.
That’s the best way to describe the relationship between alcohol and health. As I’ve written about before, a number of studies have demonstrated health benefits with lower amounts of drinking. But if you drink too much alcohol (especially at inopportune times), there may be significant harms as well. Just how these balance out remains a matter of some debate and controversy.
While it’s easy to say “too much alcohol is bad for you” (and then point out the litany of harms caused by alcohol, such as liver disease and motor vehicle accidents), it’s harder to answer these simple but important que...
Source: Harvard Health Blog - September 19, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Alcohol Health Source Type: blogs
Daily Low Dose Aspirin Fails to Extend Healthy Life Spans in Older Patients
Aspirin is arguably a calorie restriction mimetic, able to spur some of the same beneficial cellular stress responses that are activated by low nutrient levels. Calorie restriction itself, practiced over the long term, does not have a very large effect on human life span. Given the existing demographic data, a gain of even five years of life would be very surprising. Further, it is well established that the life extension resulting from calorie restriction scales down as species life span scales up. Mice live up to 40% longer on calorie restricted diets, but we humans certainly don't.
Aspirin has other effects besid...
Source: Fight Aging! - September 18, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Getting Older and Feeling Great Joy — Despite All Our Ills
“The longer I live, the more beautiful life becomes.” – Frank Lloyd Wright
While some people may think that the older you get, the worse your quality of life and well-being becomes. Yet, there are growing numbers of men and women who may now have some silver or gray strands of hair and other age-related signs who’ll tell you they’ve never felt happier. They greet each day with hope and enthusiasm, feeling confident, purposeful, grateful and filled with joy. This, despite an assortment of ailments, frailties, medical conditions and gradual slowing down.
How can it be? Does this older generation know something the...
Source: World of Psychology - September 17, 2018 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Aging General Grief and Loss Happiness Health-related Mental Health and Wellness Self-Help aches and pains joy Loving Kindness Source Type: blogs
Writing as an antidote to loneliness
It may not seem possible to be able to write your way to better health. But as a doctor, a public health practitioner, and a poet myself, I know what the scientific data have to say about this: when people write about what’s in their hearts and minds, they feel better and get healthier. And it isn’t just that they’re getting their troubles off their chests.
Writing provides a rewarding means of exploring and expressing feelings. It allows you to make sense of yourself and the world you are experiencing. Having a deeper understanding of how you think and feel — that self-knowledge — provides you with a stronger co...
Source: Harvard Health Blog - September 14, 2018 Category: Consumer Health News Authors: Jeremy Nobel, MD, MPH Tags: Behavioral Health Mental Health Stress Source Type: blogs
The Rocky Road from the Military to the VA
While serving in the military, few think about what comes next. What happens if you are injured and the physical, mental, emotional damage does not go away? Who is tasked to make you “whole” again through health care and compensation? It is a process with which most civilians, and many service members and their families have little familiarity. It is cumbersome, and starts when the individual is still in the service, with a transition program and virtually no follow up by the military.
For the last twenty years, the Department of Labor (DOL) Veterans Employment and Training Services (VETS) has provided grants to the Na...
Source: Disruptive Women in Health Care - September 10, 2018 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, September 10th 2018
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
The Price of Progress or the Waste...
Source: Fight Aging! - September 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 3rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - September 2, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The State of Evidence for a Novel TP53-DHEAS Anti-Cancer Mechanism in Primates
Are there any comparatively simple ways in which natural cancer suppression mechanisms can be greatly enhanced? This is an interesting question to consider. The current repertoire of the cancer research and medical communities include what are arguably a few examples of an enhanced natural suppression mechanism, such as the various ways to drive more cancerous cells into a state of senescence than would normally make that transition. The study of the comparative biology of aging has uncovered a variety of suppression mechanisms in naked mole rats and elephants that might lead to human therapies, but I suspect that "simple"...
Source: Fight Aging! - August 30, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 20th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - August 19, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insight into the Degree to Which Longevity is Inherited
The present consensus on the inheritance of longevity is that genetic influences over aging only rise to importance in later life. Even then it is perhaps more a matter of resistance to accumulated molecular damage and its consequences than a slower pace of aging per se. Environment and choice throughout life are the overwhelming determinants of the course of aging leading into middle age, meaning exposure to pathogens, amount of visceral fat tissue, smoking, and similar line items. That of course raises the question as to the degree to which inherited longevity is a cultural rather than genetic phenomenon. Only a tiny min...
Source: Fight Aging! - August 17, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Have You Run Out of Spoons? It ’ s Time to Replenish Your Energy Reserves
A few days ago, a friend indicated on her Facebook page that she had “run out of spoons” and asked for support and energy to be sent her way. I had heard the term but didn’t know what it meant, so I turned to Google and typed in those words and what came up was the explanation that came from a conversation between two friends, one of whom had Lupus.
Christine Miserandino was sitting at a table with her college roommate who asked her what it was like to have a disease that for many people would be considered invisible since overt symptoms may be elusive to the casual observer.
Christine pondered for an ever ...
Source: World of Psychology - August 15, 2018 Category: Psychiatry & Psychology Authors: Edie Weinstein, MSW, LSW Tags: Caregivers Inspiration & Hope Motivation and Inspiration Policy and Advocacy Stigma alone time caregiving Disability Disability Advocacy energy Rejuvenation Source Type: blogs
3D Printed Silicone and Stem Cell Implant to Treat Spinal Cord Injuries
Spinal cord injuries are notorious for the disabilities they cause and for the difficulty of finding a way to fix them. At the University of Minnesota researchers are pointing to a potential solution in the form of 3D printed scaffolds seeded with ne...
Source: Medgadget - August 13, 2018 Category: Medical Devices Authors: Editors Tags: Materials Neurology Rehab Source Type: blogs
Health4TheWorld Named Tech Startup of The Year: Interview with Founders
Health4TheWorld, a Silicon Valley start-up providing education and technology solutions for resource-poor communities worldwide, has been named the 2018 Stevie Silver Award Winner by the American Business Awards for the category of Services. Created...
Source: Medgadget - August 9, 2018 Category: Medical Devices Authors: Michael Batista Tags: Exclusive Informatics Medicine Public Health Source Type: blogs
