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Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How much “ pain ed ” do people need? And what to do when someone is not convinced …
This post has been a long time coming. There’s no doubt that giving explanations about pain mechanisms is common, and that we’ve (health professionals) been doing it a looooong time. Yes, way back to the 1970’s! In the early 1980’s when I started working in this field it was already commonplace to offer people an explanation for chronic pain (and to explain why some pains are such pains, while others bother us less – even when they involve the same degree of nociceptive input). Of course, way back then we used Gate Control Theory (GCT) to explain the distinction between hurt and harm, to explo...
Source: HealthSkills Weblog - November 27, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Education/CME Research Science in practice biopsychosocial Explain pain pain explanations PNE Therapeutic approaches Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Grip Strength Remains a Decent Biomarker of Aging
Of the various simple measures that correlate with mortality and risk of age-related disease, grip strength remains a relatively good option, even in this modern era of epigenetic clocks. Illustrative of this point, researchers here show a correlation between grip strength and epigenetic age data in a sizable study population. The degree to which an individual suffers from the chronic inflammation of aging may be an important determinant of this relationship. Inflammation disrupts tissue function throughout the body, and maintenance of muscle mass and strength is one of the aspects of health negatively affected by unresolv...
Source: Fight Aging! - November 21, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reprogramming Alone is Not Sufficient
Epigenetic reprogramming is a process of exposing cells to the Yamanaka factors for a long enough period of time to shift their epigenome towards that found in youthful tissues, but not for so long as to cause any meaningful number of them to change state into pluripotent stem cells. It is an attempt to reproduce aspects of the cellular rejuvenation that occurs in the initial stages of embryogenesis, without harming the functional specialization of the cells so altered. It works surprisingly well in animal studies, considering all of the very reasonable a priori objections as to why we should believe that such an embryonic...
Source: Fight Aging! - November 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamma...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
forgetting my heart
When I was in college I spent a semester living in Germany and traveling around Europe. I started taking German in 9th grade, but 7 years later when I went to Germany, I still struggled with basic conversation. Many of my classmates grew up in German speaking families and they had a distinct advantage being bilingual. By the time I came back home though, I was fluent enough that I could carry on all my daily activities, eating, shopping, traveling, finances, etc in German. I was really proud of that accomplishment.
When I returned though, i experienced something unusual that I haven’t heard other people talk about...
Source: Mr. Hassle's Long Underpants - October 30, 2022 Category: Emergency Medicine Authors: Doc Shazam Tags: Tales grief Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
October 27, 2022 Edition-----In the UK we have a political farce running with only a day or so to run when you read this, with a new PM (Rishi Sunak) in place..In the US the mid-term elections are coming in a week or so, thus some concern as to where the US is going!In China Xi has his third 5 year term so we all wonder how that will turn out!In OZ we have has a Budget with floods, inflation, data leaks, the threat of recession, Medicare concerns and other issues just rolling on! At least the Budget does not seem to have broken anything!Overall an ‘omnishambles’ as they say!-----Major Issues.-----https://www.afr.com/wo...
Source: Australian Health Information Technology - October 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Social Security ’s COLA Increase Is Based on an Outdated Inflation Measure
Romina BocciaSocial Security just announced the biggest increase in beneficiaries ’ cost-of-living adjustment (COLA) in 40 years: 8.7%. The trouble is, Social Security is using an outdated measure that’s driving up benefit costs. The so-called chained CPI would protect seniors’ purchasing power while extending Social Security’s ability to provide benefits.Social Security benefits are indexed for inflation to protect beneficiaries from a decline in purchasing power when the prices of goods and services rise. That ’s generally a good thing. The 8.7 percent COLA increase, announced today, is a direct result of the 4...
Source: Cato-at-liberty - October 13, 2022 Category: American Health Authors: Romina Boccia Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links – 8th October, 2022.
This report aligns with the reality that healthcare organizations are facing in terms of the effects to patient safety, " said Anahi Santiago, chief information security officer at Delaware-based ChristianaCare.She and other healthcare cybersecurity leaders spoke withHealthcare IT News about the connection between cyber hygiene and patient safety and how to prepare for healthcare cyber attacks. -----https://ehrintelligence.com/news/meaningful-use-ehrs-may-be-key-to-improved-quality-of-care‘Meaningful Use’ EHRs May Be Key to Improved Quality of CareHospitals that meet the “Meaningful Use” EHR requirements were ...
Source: Australian Health Information Technology - October 8, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks ...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Overseas Health IT Links –24th September, 2022.
This article makes the case and explains what will be required to make it happen.We hear a lot about “digital health” these days. As data about our health piles up — thanks to sources like electronic health records, personal fitness apps and gadgets, and home genome test kits — weshould understand a lot more than we used to about what ’s wrong with our health and what to do about it. But having a lot of data is not enough. We have to be aware of what we have, understand what it means, and act on that understanding. While the challenges are in some ways more acute in the United States because of its fragmented sys...
Source: Australian Health Information Technology - September 24, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
