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Weekly Australian Health IT Links – 1 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot this week – especially regarding the NBN and Labor trying to regain control of what it is actually for – service provision – and not making a huge profit – in their view. Love the new Minister has ambitions to be maximally photogenic and not a ‘techie’!Otherwise all sorts of fun things!-----https://www.ausd...
Source: Australian Health Information Technology - August 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree Towards Scaffold-Based Regeneration of Dental Pulp https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/ Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The stories we tell ourselves about the past
The concept of narrative captured my interest sometime around 1984 - ironically - because it may have been the Orwell novel with that year ' s title that prompted my thinking on the topic.I was interested in written narrative and how Winston Smith established his rebellion and then his freedom through a written form (even if it all eventually led to a horrible end). I was also fascinated by his attraction to the paperweight that he purchased - something that was old - and seemingly of unknowable utility.What was the purpose of knowledge, or of the past - except that it all did represent a freedom from the drudgery of the p...
Source: ABC Therapeutics Occupational Therapy Weblog - June 16, 2022 Category: Occupational Health Tags: ABC Therapeutics OT practice OT stories parenting Source Type: blogs

Inflammaging as a Contributing Factor in the Development of Cardiovascular Disease
Inflammaging is the name given to the decline of the aging immune system into a state of constant, unresolved inflammation. Inflammatory signaling in the aged body arises in part because of an increased burden of senescent cells. These cells secrete a potent mix of pro-inflammatory signals, disrupting tissue function. This is one of the reasons why removal of lingering senescent cells produces such rapid rejuvenation, as these errant cells actively maintain a portion of the degradation of function and environment in aged tissues. Beyond senescent cells, the broad molecular damage and cellular dysfunction of aging produces ...
Source: Fight Aging! - June 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - June 07, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon.-----h...
Source: Australian Health Information Technology - June 7, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Navitoclax is Better than Dasatinib and Quercetin at Clearing Senescent Cells Produced by Radiotherapy
It is now well known that many of the negative consequences resulting from chemotherapy and radiotherapy are mediated by a raised burden of senescent cells. One of the goals of cancer therapy is to drive cancerous cells into senescence: better to have senescent cells than cancerous cells! Nonetheless, gaining a greater burden of senescent cells is literally accelerated aging, as these additional senescent cells actively degrade tissue function and create chronic inflammation via their secretions. Thus senolytic therapies should be of great benefit to cancer survivors, removing this harmful side-effect of cancer therapy. ...
Source: Fight Aging! - May 30, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cancer
I just finished reading The Emperor of All Maladies: A biography of cancer, by Siddhartha Mukherjee. I have a quibble with the title -- it should be history, not biography. By personifying cancer, he plays into just the mythologizing he is trying to dispel. But that aside, I found the book very informative. I knew the general outline of the story, but not a lot of the details. What I want to comment on here, which I believe is the key takeaway, is that medical practice is subject to ideological capture, even in the modern era of " scientific " medicine. In the center of the book is the horror story of radical mastecto...
Source: Stayin' Alive - May 29, 2022 Category: American Health Source Type: blogs

Fight Aging! Newsletter, May 30th 2022
In conclusion, fisetin supplementation may be a novel strategy to target excess cellular senescence and thereby reduce mitochondrial ROS to improve NO-mediated endothelial function with aging. Exercise Upregulates BDNF Expression to Promote Dopamine Release and Brain Function https://www.fightaging.org/archives/2022/05/exercise-upregulates-bdnf-expression-to-promote-dopamine-release-and-brain-function/ Researchers have in the past shown that exercise results in greater amounts of BDNF, which in turn promotes neurogenesis. Here, this line of research is extended to show that exercise results in an increas...
Source: Fight Aging! - May 29, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan. Naked Mole-Rat Skin Shows Fewer Signs of Aging https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/ Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem c...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How to Convince a Older Adult with Incontinence to Wear Adult Diapers
Photo credit Mathias Konrath Incontinence is a condition that is often difficult for a person to accept and deal with. Many seniors try to ignore this new development and carry on with their lives, but a head-in-the-sand approach usually draws more attention to the problem. There are ways to encourage a loved one to address this issue, but they require patience, understanding and a commitment to upholding your loved one’s dignity. Pro Tip: Strike the Word Diaper from Your Vocabulary “My parent won’t wear adult diapers and it drives me nuts!” This is a common complaint from family caregivers whose loved ones are suf...
Source: Minding Our Elders - May 11, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects. More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/ You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these c...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Compression of Morbidity Not Observed in Nematode Longevity Mutants
Compression of morbidity is a reduction in the length of time spent in significant illness or disability at the end of life. It is often touted as a goal in human medicine by those who, for various reasons, don't want to talk about the prospects for extending overall life span through progress in medicine. If we think about aging in terms of damage to a machine, then in the simple model of a single form of damage, compression of morbidity would not be expected to occur in response to a slowed accumulation of damage. Fully functional life span would extend, but so would the period of progressive onset of dysfunction. ...
Source: Fight Aging! - May 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available. A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/ Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off betw...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs