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Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Slideshow: Mitosis Masterpieces
The intricate process of
mitosis—a cell splitting into two identical daughter cells—plays a pivotal role in sustaining life. Many scientists study this process to understand what’s needed for it to progress normally and why it sometimes goes awry, such as in cancer. During their research, the scientists often create eye-catching images and videos, and we showcase some of those visuals here.
Check out our post Make Like a Cell and Split: Comparing Mitosis and Meiosis for more info on mitosis, and visit our image and video gallery for more examples of mitosis, as well as other scientific photos, illustrations...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 10, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Cellular Imaging Cellular Processes Cool Images Cool Videos Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What the Pandemic Taught Us About Value-based Care
By RICHARD ISSACS
You’ll recall that we ran a long piece (pt 1, pt 2) about Medicare Advantage from former Kaiser Permanente CEO George Halvorson earlier this year. Here’s a somewhat related piece from the current head of the Permanente Medical Group about what actually happened there and elsewhere during the pandemic–Matthew Holt
The COVID-19 pandemic has provided important lessons regarding the structure and delivery of health care in the United States, and one of the most significant takeaways has been the need to shift to value-based models of care.
The urgency for this transformation was cle...
Source: The Health Care Blog - February 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Physicians Kaiser Permanente Medicare Advantage Pandemic Richard Isaacs value-based care Source Type: blogs
Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity.
This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Altos Labs Officially Launches with $3 Billion in Funding to Tackle In Vivo Reprogramming
Altos Labs was formed to develop in vivo reprogramming into a viable class of therapies to treat aging. Reprogramming occurs during embryonic development, and the discovery of the Yamanaka factors allows this process to be enacted in any cell. To date this has largely been used in the development of induced pluripotent stem cells, a source of cells for research and therapy. The other effects of reprogramming are coming to be just as interesting, however: a resetting of the epigenetic marks characteristic of cells in old tissues, and a restoration of mitochondrial function. Studies in mice show that partial reprogramming, r...
Source: Fight Aging! - January 19, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A Roundup of 2021 ’ s Quality Quotes
Happy almost New Year! Throughout 2021 we spoke to more than two dozen NIGMS-supported researchers for the Biomedical Beat blog. They shared their work, career journeys, experiences with the COVID-19 pandemic, and more. Here, we’re showcasing a few of their outstanding quotes. You can learn more about these scientists by checking out the links to the original blog posts.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 29, 2021 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making first contact: What to do with all that information! part 2
Last week I described some of the reasons for using a case formulation approach when working through initial assessment information, and today I’m going to describe one approach for organising a formulation. This is the “4 P” formulation, and it’s one that’s often used in mental health (Bolton, 2014).
In the 4 P model, there are four questions to ask yourself:
Preconditions – Why is this person vulnerable to this problem?Precipitating factors – Why now? This can mean “why is this person having symptoms now?” or “why is this person presenting to this person ...
Source: HealthSkills Weblog - November 28, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Chronic pain Clinical reasoning Pain conditions Professional topics Research Science in practice biopsychosocial case formulation Occupational therapy pain management Therapeutic approaches Source Type: blogs
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously pr...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age, ...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
