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Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects." Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

CRAZY AMERICA: Health Insurance Covers Testing When You Are Well But Not When You Are Sick
By HANS DUVEFELT Insurance is the wrong word for what we have here. Our private health insurance system’s prioritization of sometimes frivolous screenings but non-coverage for common illnesses and emergencies is a travesty and an insult to typical American middle class families. State Medicaid insurance for the underemployed has minimal copays of just a few dollars for doctor visits and medications. From my vantage point as a physician, it is the best insurance a patient can have. They cover almost everything and it is clear to me how to apply for exceptions or follow their step care requirements. I cannot...
Source: The Health Care Blog - December 9, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Source Type: blogs

Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations. Data on the Prevalence of Liver Fibrosis in Middle Age https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/ Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options a...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

9 Technologies That Will Shape The Future Of Dentistry
One of the most common childhood fears is going to the dentist. Who would not relate? Sitting in a huge chair illuminated by blinding light; enduring lengthy seated sessions with someone looking and poking inside your mouth using edgy and frightening devices. And finally, when the torture is over, that same someone tells you not to eat your favourite sweets and instructs you to brush your teeth regularly.  We’ve all been through this as a kid and childhood memories stick with us; just recalling this might send a shiver down your spine. No one likes to go to the dentist in spite of the fact that everyone knows how crucia...
Source: The Medical Futurist - November 3, 2020 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Biotechnology E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Medical Education Telemedicine & Smartphones Virtual Reality AI augmented reality dig Source Type: blogs

Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings. In Vivo Reprogramming Improves Cognitive Function in Old Mice https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mic...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for. Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia. Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training. About our Guest Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs

Inside Schizophrenia: Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for. Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia. Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training. About our Guest Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs

Health Care 101, continued
Okay, back to where we were before I was so rudely interrupted. As we have established, insurance is about risk pools. Sure, you can offer a cheap policy if you only sell it to people who are young and healthy, and that ' s what would happen in a non-regulated ( " free " ) market; but that would be largely pointless. As soon as somebody actually needed the insurance, they would not be able to renew it. People who are fortunate enough to have employer-provided insurance (which is an oddity largely specific to the United States, for historical reasons we won ' t go into there) don ' t generally have this problem. Employ...
Source: Stayin' Alive - October 13, 2020 Category: American Health Source Type: blogs

Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cures for Cerumen Impaction
​Cerumen impaction removal may not be considered an emergent procedure in the emergency department, but this omnipresent natural phenomenon will bring patients, from infants to the elderly, to your department at all hours of the day and night because loss of hearing is a foreign and uncomfortable sensation.Cerumen impaction can cause complete hearing loss, pain, dizziness, chronic cough, and even infection. Patients who attempt to remove cerumen at home can end up with otitis externa or otitis media and even tympanic membrane trauma. The cerumen can block visualization of the tympanic membrane so TM rupture or ear infect...
Source: The Procedural Pause - October 1, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Injection of Metformin Improves Cognitive Function in Old Mice to a Greater Degree than Oral Administration
Researchers here note that delivering metformin via injection rather than the usual oral administration removes unwanted side-effects and better improves cognitive function in old mice. Near all testing of metformin has used oral administration, and the effects on pace of aging and life span are, frankly, too unreliable and too small to justify the present level of interest in the drug on the part of the longevity community. Administration by injection might be a different story, but waiting on further research and confirming data would be a wiser course of action than immediate excitement. Even then, this is tinkering wit...
Source: Fight Aging! - September 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Medical AI Floodgates Open, at a Cost of $1000 per Patient
By LUKE OAKDEN-RAYNER In surprising news this week, CMS (the Centres for Medicare & Medicaid Services) in the USA approved the first reimbursement for AI augmented medical care. Viz.ai have a deep learning model which identifies signs of stroke on brain CT and automatically contacts the neurointerventionalist, bypassing the first read normally performed by a general radiologist. From their press material: Viz.ai demonstrated to CMS a significant reduction in time to treatment and improved clinical outcomes in patients suffering a stroke. Viz LVO has been granted a New Technology Add on Payment of up to&nb...
Source: The Health Care Blog - September 10, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech AI Luke Oakden-Rayner Reimbursement Source Type: blogs