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Total 70 results found since Jan 2013.

Research and Reviews in the Fastlane 056
This article offers solutions in which he calls for a shift in the research mentality. The pearls: Focus on replication of research findings (and reward this) Broad collaboration and data sharing Altering the reward system for publication and academic advancement (i.e. reward not the number of publications but their impact; focus on the quality of peer review) Recommended by Lauren Westafer Resuscitation, Emergency MedicineSmekal D et al. CPR-related injuries after manual or mechanical chest compressions with the LUCAS™ device: A multicentre study of victims after unsuccessful resuscitation. Resuscitation 2014. PMID ...
Source: Life in the Fast Lane - November 4, 2014 Category: Emergency Medicine Authors: Soren Rudolph Tags: Cardiology Education Emergency Medicine Infectious Disease Intensive Care Neurology Neurosurgery R&R in the FASTLANE Resuscitation Wilderness Medicine acute coronary syndrome airway blood transfusion critical care ENT Review Source Type: blogs

Reconstruction of 1918-like avian influenza virus stirs concern over gain of function experiments
The gain of function experiments in which avian influenza H5N1 virus was provided the ability to transmit by aerosol among ferrets were met with substantial outrage from both the press and even some scientists; scenarios of lethal viruses escaping from the laboratory and killing millions proliferated (see examples here and here). The recent publication of new influenza virus gain of function studies from the laboratories of Kawaoka and Perez have unleashed another barrage of criticism. What exactly was done and what does it mean? According to critics, virologists should not be entrusted to carry out gain of function studie...
Source: virology blog - June 20, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information 1918 pandemic aerosol transmission avian influenza ferret gain of function H5N1 viral virus Source Type: blogs

TWiV 282: Tamiflu and tenure too
On episode #282 of the science show This Week in Virology, the TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws. You can find TWiV #282 at www.twiv.tv.
Source: virology blog - April 27, 2014 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral biomedical research Cochrane collaboration influenza meta-analysis NIH grant oseltamivir PhD student postdoctoral scientist systemic flaws tamiflu virus Source Type: blogs

Deadly Medicines and Organised Crime: a review
This is a web version of a review of Peter Gotzsche’s book. It appeared in the April 2014 Healthwatch Newsletter. Read the whole newsletter. It has lots of good stuff. Their newsletters are here. Healthwatch has been exposing quackery since 1989. Their very first newsletter is still relevant. Most new drugs and vaccines are developed by the pharmaceutical industry. The industry has produced huge benefits for mankind. But since the Thatcherite era it has come to be dominated by marketing people who appear to lack any conscience. That’s what gave rise to the Alltrials movement. It was founded in January 2013...
Source: DC's goodscience - April 16, 2014 Category: Science Authors: David Colquhoun Tags: Academia badscience Big Pharma blogosphere Martin Keller Peter Gotzsche Pharmaceutical Industry Richard Eastell Source Type: blogs

I'm baaaaaack . . .
It was just too painful to type for a few days so I decided not to bite the bullet. People ask me what I do for a living and I say I'm a medical sociologist, but now I realize that a better job description is typist. Anyway . . .Millions of people are locked up for shoplifting and smoking pot and shooting dope, but if you steal $20 billion you're cool. I don't know how much of this you can read, but the new BMJ has a theme issue on the latest fraud of the century. The story is that in 2006, one Tom Jefferson led a Cochrane review* of neuraminidase inhibitors -- these are drugs to treat influenza, most notably oseltamavir (...
Source: Stayin' Alive - April 14, 2014 Category: American Health Source Type: blogs

Yet another avian influenza virus, H10N8, infects humans
To the collection of avian influenza viruses known to sporadically infect humans – H5N1, H7N9, H7N2, H7N3, H7N7, H9N2, and H10N7 – we can now add H10N8, recently found in two individuals in China. Avian influenza virus H10N8 was first detected in tracheal aspirates from a 73 year old woman who was hospitalized in November 2013 for severe respiratory illness. The patient, who died, had previously visited a live poultry market. A second infection with this virus was detected in January 2014. Virus isolated from tracheal aspirates on day 7 of illness was named A/Jiangxi-Donghu/346/2013(H10N8). Nucleotide sequence ...
Source: virology blog - February 10, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information avian influenza China H10N8 H5N1 h7n9 HA viral virus zoonosis zoonotic Source Type: blogs

It's coming. It's coming for all of us.
At this point, it doesn't matter whether it's a mismatch between this year's flu shot and this year's virus, or a secret government plot, or just plain crappy luck: everybody I know, practically, has the flu.We have nine full-time nurses in our unit. Two of them have pneumonia. A third is out for another week, until the Tamiflu and chicken soup kick in. The remaining half-dozen of us are bathing in alcohol foam, refusing to get too close to each other (I swear; it's like Sweden up in there), and running away from anybody with the slightest hint of a cough. I myself have taken to bathing daily in boiling bleach and wrapping...
Source: Head Nurse - February 5, 2014 Category: Nurses Authors: Jo Source Type: blogs

Some additional thoughts on systematic reviews
This article has been read over 8,500 times and has opened up numerous separate discussions around systematic reviews and the nature of evidence.  It's still a topic I find fascinating and have moved my thinking on further.This post follows my presentation at the Rethinking Evidence-Based Medicine: from rubbish to real meeting a short while ago....In 2005 Richard Smith, former editor of the BMJ wrote the article Medical Journals Are an Extension of the Marketing Arm of Pharmaceutical Companies in Plos Medicine.  It starts with a quote from the editor of The Lancet, Richard Horton, "Journals have devolved into inf...
Source: Liberating the literature - February 4, 2014 Category: Technology Consultants Source Type: blogs

What's A Rhino Got To Do With It?
So it would of course be par for the course so to speak that as I attempt to get this up and running again I would be hit with illness. Usually my hospital visits entail being told that I have a virus of some unknown origin never given a name. I've come to accept that as reality. However, when I called out of work on Tuesday and decided that since I am in Management now I probably should have an excuse from a doctor when I call off I made the trek downtown to see my doctor on Tuesday. I got in his office, he finished the exam, politely excused himself came back a few minutes later and told me that he felt admission to the ...
Source: Still arriving. - February 2, 2014 Category: HIV AIDS Source Type: blogs

Cutting through mucus with the influenza virus neuraminidase
Neuraminidase is one of three different viral proteins embedded in the lipid membrane of influenza virus (NA is blue in the illustration at left). This enzyme has a clear and proven role in virus release from cells. NA is also believed to be important during virus entry, by degrading the mucus barrier of the respiratory tract and allowing virus to reach cells. This role is supported by the finding that treatment of mucus-covered human airway epithelial cells with the NA inhibitor Tamiflu substantially suppresses the initiation of infection.  Further evidence comes from the recent finding that influenza virus binds to sial...
Source: virology blog - January 9, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information influenza mucus NA neuraminidase oseltamivir tamiflu viral virus Source Type: blogs

Drug firms accused of holding back complete information on clinical trials
A review of 20 existing studies into Tamiflu by the Cochrane Collaboration concluded it 'did not reduce influenza-related lower respiratory tract complications'. Photograph: Clive Gee/PAClinical trial results are being routinely withheld from doctors, undermining their ability to make informed decisions about how to treat patients, an influential parliamentary committee has claimed.MPs have expressed "extreme concern" that drug manufacturers appear to only publish around 50% of completed trial results and warned that the practice has "ramifications for the whole of medicine".Their conclusions have emerged in a public accou...
Source: PharmaGossip - January 3, 2014 Category: Pharma Commentators Authors: insider Source Type: blogs

Hilarious Tamiflu side-effect
Okay, it’s not hilarious, it’s funny that it’s included as a side effect of Tamiflu (treatment for influenza): I’m not a huge fan of Tamiflu (for the neuropsychiatric side effects), but I saw this last night on my pocket brain, and had to look today to see if it’s really listed. It is, that’s off the Tamiflu full-download of the medication information (Link on the official Tamiflu page). So you know, when patients are in studies, basically everything that happens while the subject is taking the medication has to be reported to the FDA, which is how all that oddness gets enshrined as les...
Source: GruntDoc - November 26, 2013 Category: Emergency Medicine Doctors Authors: GruntDoc Tags: Amusements Emergency Source Type: blogs

Changing influenza virus neuraminidase into a receptor binding protein
The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of the influenza virus particle serve distinct functions during infection. The HA binds sialic acid-containing cellular receptors and mediates fusion of the viral and cell membranes, while the NA removes sialic acids from glycoproteins. Apparently this division of labor is not absolute: influenza viruses have been identified with NA molecules that serve as receptor binding proteins. An influenza virus was created that could not bind sialic acid by introducing multiple mutations into the HA gene. This mutant virus was not expected to be infectious, but nevertheless...
Source: virology blog - November 21, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information evolution HA hemagglutinin influenza mutation NA neuraminidase receptor binding sialidase tamiflu viral virus Source Type: blogs

The neuraminidase of influenza virus
This article is part of Influenza 101, a series of posts about influenza virus biology and pathogenesis.
Source: virology blog - November 5, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information glycoprotein influenza neuraminidase relenza sialic acid spread tamiflu viral virus Source Type: blogs