Filtered By:
Drug: Tamiflu

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 70 results found since Jan 2013.

Incidence of asymptomatic human influenza A(H5N1) virus infection
When virologists Fouchier and Kawaoka were isolating avian influenza H5N1 viruses that could transmit among ferrets by aerosol, there was consternation from some quarters that such viruses might escape from the laboratory and cause a pandemic in humans. Part of the fear came from the fact that the case fatality ratio for human infections with the H5N1 virus exceeds 50%. This number could be substantially higher than the lethality ratio, which is the number of symptomatic cases divided by the total number of infections. Divining the latter number has been difficult. Results of a meta-analysis published in 2012 suggest that...
Source: virology blog - October 1, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information asymptomatic avian Bangladesh case fatality ratio fouchier influenza A(H5N1) kawaoka mortality ratio viral virus Source Type: blogs

Why Big Pharma is bad for your health
Just take one and you’ll feel better. Promise (Image from shutterstock).On Wednesday I came down with a stinking cold. Loaded up with all the cold and ‘flu medication I could find on the pharmacist’s shelves I headed into the office where I found on my desk a pre-ordered copy of Ben Goldacre’s new book Bad Pharma: How drug companies mislead doctors and harm patients.I had read and enjoyed Goldacre’s previous book ‘Bad Science‘, an accessible and entertaining exploration of the world of medicine. I have not touched a homeopathic sugar pill or written an ill-informed scientific article since. Not that...
Source: PharmaGossip - September 22, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Tamiflu saga continues - NYT. By Katie Thomas
Breaking the Seal on Drug ResearchPETER DOSHI walked across the campus of Johns Hopkins University in a rumpled polo shirt and stonewashed jeans, a backpack slung over one shoulder. An unremarkable presence on a campus filled with backpack-toters, he is 32, and not sure where he’ll be working come August, when his postdoctoral fellowship ends. And yet, even without a medical degree, he is one of the most influential voices in medical research today.Dr. Doshi’s renown comes not from solving the puzzles of cancer or discovering the next blockbuster drug, but from pushing the world’s biggest pharmaceutical companie...
Source: PharmaGossip - June 30, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Top stories in health and medicine, May 29, 2013
Brought to you by MedPage Today. 1. Don’t Stop Warfarin for Dental Visits. Patients taking aspirin or warfarin (Coumadin) for prevention after a stroke don’t need to stop the drug for dental procedures and probably can stay on it for most other minor medical procedures. 2. Silent Afib Linked to Stroke in Diabetics. Asymptomatic atrial fibrillation might lie behind stroke of unknown origin in patients with type 2 diabetes. 3. Tamiflu Resistance Confirmed in H7N9 Flu Cases. Chinese researchers reported, for the first time, clinical evidence of oseltamivir (Tamiflu) resistance in patients infected with the novel a...
Source: Kevin, M.D. - Medical Weblog - May 29, 2013 Category: Family Physicians Tags: News Heart Infectious disease Neurology Source Type: blogs

Pharmalot... Pharmalittle... Good Morning
Hello, everyone, and nice to see you again. We hope you enjoyed the long weekend - at least on this side of the pond - and feel somewhat refreshed and reinvigorated. After all, that familiar routine of meetings and deadlines has returned. To fortify ourselves, yes, we are turning to our ritualistic cup of stimulation. We need all the help we can get. As always, we invite you to join us. While you do so, here are some tidbits. Have a great day and do stay in touch... AstraZeneca To Buy Omthera Pharma For Up To $433 Million (Reuters) Is Amarin Valued At Less Thanks To Astra Deal To Buy Omthera? (The Street) FDA Rejects Valea...
Source: Pharmalot - May 28, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs

Bringing trial data out of the shadows
All sectors have their own mood music, unobtrusive much of the time, but occasionally brought to startling effect into the foreground, dominating all else. The pharmaceutical industry is no different, and at present there is one insistent theme: transparency.And if there is one area of this debate behind which chords are starting to swell loudly it is the availability of clinical trial data. Unflattering or disappointing trial outcomes have been routinely unpublished, pharma's critics claim, which means patients taking part in trials can be exposed to ineffective or even dangerous products because previous negative researc...
Source: PharmaGossip - May 13, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Fixing Pharma's Reputation: IMHO, the Train Has Left the Station
In an "open letter" to PhRMA CEO, John Castellani, Forbes Blogger and former president of Pfizer Global Research, John LaMattina, offers several suggestions for improving the reputation of the pharmaceutical industry. You can read the "letter" here.Unfortunately, IMHO, the "train has already left the station" as they say. In fact, the train has crashed!You might recall that LaMattina famously called for the end of DTC (direct-to-consumer) advertising in his book, Devalued and Distrusted (see "Bad, Devalued, Distrusted & Defensive Pharma: A Tale of Two Books").In his open letter, however, LaMattina focuses on the R&...
Source: Pharma Marketing Blog - April 21, 2013 Category: Pharma Commentators Tags: R and D Research Sales and Sales Reps Reputation Source Type: blogs

Half of Tamiflu prescriptions went unused during 2009 swine flu pandemic
Around 50% of the Tamiflu prescriptions issued during the influenza pandemic in 2009–10 went unused in England, a study by the UK’s Centre for Ecology & Hydrology (CEH) has found. The unused medication represents approximately 600,000 courses of Tamiflu at a cost of around £7.8m to the UK taxpayer. The finding, published online in the open access scientific journal Plos One, comes from the first study of its kind to use sewage water to estimate drug compliance rates. The study estimated usage of pharmaceuticals from large populations by sampling sewage and recovering the active component of Tamiflu, thus measuring d...
Source: PharmaGossip - April 17, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Avian influenza H7N9 viruses isolated from humans: What do the gene sequences mean?
There have been over 60 human infections with avian influenza virus H7N9 in China, and cases have been detected outside of Shanghai, including Beijing, Zhejiang, Henan, and Anhui Provinces. Information on the first three cases has now been published, allowing a more detailed consideration of the properties of the viral isolates. The first genome sequences reported were from the initial three H7N9 isolates: A/Shanghai/1/2013, A/Shanghai/2/2013, and A/Anhui/1/2013. These were followed by genome sequences from A/Hongzhou/1/2013 (from a male patient), A/pigeon/Shanghai/S1069/2013), A/chicken/Shanghai/S1053/2013), and A/en...
Source: virology blog - April 17, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information China H5N1 h7n9 H9N2 influenza pandemic poultry viral virus zoonosis zoonotic Source Type: blogs

The Myth of Tamiflu: 5 Things You Should Know - by Harlan Krumholz
Influenza-like-illness is sweeping the country with the Centers for Disease Control & Prevention reporting that most areas of the country experiencing high rates. I should know, my family is in the midst of it despite having been vaccinated. This year may rival some of the worst years in recent history. These illnesses are more than uncomfortable – they can cause life-threatening complications. Worries about complications lead many people to want to be prepared with a treatment. I have a friend who once stockpiled Tamiflu, an antiviral agent sold by Roche, wanting to be prepared to protect his friends and family. He was...
Source: PharmaGossip - April 13, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

A critique of the Cochrane Collaboration
In this study the authors compared the performance of McMaster Premium LiteratUre Service (PLUS) and Clinical Queries (CQs) to that of the Cochrane Controlled Trials Register, MEDLINE, and EMBASE for locating studies added during an update of reviews. They concluded that PLUS included less than a quarter of the new studies in Cochrane updates, but most reviews appeared unaffected by the omission of these studies.  In other words, you do not necessarily need to get all articles to arrive at an accurate effect size (compared to the Cochrane systematic review).3)    A pragmatic strategy for the review of c...
Source: Liberating the literature - April 7, 2013 Category: Technology Consultants Source Type: blogs

First human infections with avian influenza H7N9 virus
Fourteen people in China have been infected with avian influenza H7N9 virus, leading to five deaths. This avian influenza virus has never been isolated from humans. Influenza A viruses with the H7 hemagglutinin protein circulate among birds, and some, such as H7N2, H7N3, and H7N7, have been previously found to infect humans. It is not known how the individuals in China acquired the H7N9 virus. Some of the infections have occurred in Shanghai, where a similar virus was found in pigeon samples collected at a marketplace in that city. It is not clear what types of pigeon samples tested positive for the virus, nor is it known...
Source: virology blog - April 5, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information avian influenza China h7n9 H9N2 HA hemagglutinin pandemic reassortant Shanghai viral virus Source Type: blogs

Roche offers researchers access to all Tamiflu trials
BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f2157 (Published 4 April 2013) Cite this as: BMJ 2013;346:f2157 Article Related content Article metrics Deborah Cohen Author Affiliations More than three years after the Cochrane Collaboration first asked Roche for the full clinical study reports for its influenza drug oseltamivir (Tamiflu), the Swiss company has offered the collaboration access to “all 74 Roche sponsored trials.” Don MacLean, life cycle leader for Tamiflu at Roche, emailed the Cochrane researchers on 2 April to propose providing d...
Source: PharmaGossip - April 4, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

TWiV 223: EEEV and the serpent
On episode #223 of the science show This Week in Virology, Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells. You can find TWiV #223 at www.twiv.tv.
Source: virology blog - March 10, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology alphavirus coronavirus EMC eastern equine encephalitis virus EEEV human airway epithelial cells influenza neuraminidase relenza snakes tamiflu togavirus viral zoonotic Source Type: blogs