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Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Efforts Continue to Use COVID-19 as a Learning Moment Regarding the Costs of Aging
Near everyone who dies from the SARS-Cov-2 virus responsible for the COVID-19 pandemic is old. The old are vulnerable firstly because their immune systems are much diminished in effectiveness, and secondly because the state of chronic inflammation characteristic of old age makes the cytokine storm that causes much of the SARS-Cov-2 mortality more likely and more severe. Members of the medical research community focused on intervention in the aging process - a way to treat all age-related conditions by addressing their underlying causes - are attempting to use the attention given to COVID-19 to educate the public and...
Source: Fight Aging! - July 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

I Joined Twitter to Teach
I joined Twitter to teach. In May 2016, I started tweeting “questions of the day” for my inpatient hospital medicine team at Thomas Jefferson University Hospital from @RJmdphilly. #GreenQOD (“Green” is our teaching service, and “QOD” for question of the day) was born in the days of only 140 characters per tweet (now expanded to 280), which placed a potentially daunting onus on brevity in phrasing—and answering—clinical questions. My inaugural question? “What’s the real story with beta blockers in reactive airway disease? If increase risk is real, how do you balance risk/benefit?” Rules of t...
Source: Academic Medicine Blog - June 30, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective social media teaching Twitter Source Type: blogs

Escaping COVID-19
By RAGHAV GUPTA, MD “In seeking absolute truth, we aim at the unattainable and must be content with broken portions.” William Osler A colleague shared an experience with me about testing one of his patients for the novel coronavirus and it left me a bit puzzled.  An elderly gentleman with past medical history of severe COPD (chronic obstructive pulmonary disease) and heart failure came to the ER with shortness of breath, edema and fatigue.  Chest x-day suggested pulmonary edema.  He wanted to test him for SARS-CoV2 but hesitated.  Eventually he was able to order it ...
Source: The Health Care Blog - June 4, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Uncategorized Source Type: blogs

What ’s a diagnosis about? COVID-19 and beyond
By MICHEL ACCAD Last month marked the 400th anniversary of the birth of John Graunt, commonly regarded as the father of epidemiology.  His major published work, Natural and Political Observations Made upon the Bills of Mortality, called attention to the death statistics published weekly in London beginning in the late 16th century.  Graunt was skeptical of how causes of death were ascribed, especially in times of plagues.  Evidently, 400 years of scientific advances have done little to lessen his doubts!  A few days ago, Fox News reported that Colorado governor Jared Polis had “pushed back against recen...
Source: The Health Care Blog - May 28, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Diagnosis MICHEL ACCAD Source Type: blogs

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Covid-19 Reuters Q & A with William Haseltine
I live-tweeted a fascinating and perhaps rather depressing meeting with William Haseltine via a Reuters Newsmaker Broadcast. His talk was upbeat but the message does not offer a positive outlook unless we can collaborate internationally to identify, trace, and isolate and go back to early antivirals to treat people urgently. A vaccine will probably never be found, we must stay on top of this virus when we get communities under control. Moreover, we must recognise that another emergent pathogen could appear any time. These are essentially my notes from Haseltines’s talk. Might we ever achieve herd immunity? There is n...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 20, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Covid-19 Reuters Newsmaker Broadcast with William Haseltine
I live-tweeted a fascinating and perhaps rather depressing meeting with William Haseltine via a Reuters Newsmaker Broadcast. His talk was upbeat but the message does not offer a positive outlook unless we can collaborate internationally to identify, trace, and isolate and go back to early antivirals to treat people urgently. A vaccine will probably never be found, we must stay on top of this virus when we get communities under control. Moreover, we must recognise that another emergent pathogen could appear any time. These are essentially my notes from Haseltines’s talk. Might we ever achieve herd immunity? There is n...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 20, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Patients & Vulnerable Populations Pandemically Left in the Dark
By GRACE CORDOVANO PhD, BCPA To be honest, the United States blew it on the mask front. From a public health, caregiver and patient safety, as well as community transmission standpoint, we are at least 3 months late to game. Anytime a brand new virus that humanity does not have any immunity to makes an appearance, is highly contagious, starts rapidly infecting people as well as the doctors and nurses caring for them, hospitalizing, and killing them in concerning numbers across the globe, we should enable every proactive safety measure at our disposal. The first confirmed case of COVID-19 in the US was on January 20,...
Source: The Health Care Blog - April 7, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy coronavirus Grace Cordovano masks Pandemic Source Type: blogs

Nurse Keith ' s 4-1-20 COVID-19 Roundup
In these days of the COVID-19 pandemic, it seems like the world is upside down and inside out. We are all reeling from the overwhelming disruption of most every aspect of human life: economics, work, and career; education across the lifespan, from preschool to post-doctoral research; faith communities; migrant workers; the undocumented; the frail, elderly, and vulnerable; transportation; small business; and the actual details of survival, including food, clothing companionship, and shelter.Other than those still living who experienced World War II, the Holocaust, or even the 1918 so-called " Spanish Flu " , none of us have...
Source: Digital Doorway - April 2, 2020 Category: Nursing Tags: coronavirus COVID-19 healthcare medicine public health Source Type: blogs

Podcast: Don ’ t Let Coronavirus Impact Your Mental Health
 It’s often said that fear is the most dangerous virus on the planet. While a relatively small percentage of people will contract the new coronavirus, or COVID-19, the fear it provokes will chip away at the mental health of nearly everyone who hears about it. So why does COVID-19 inspire so much fear when there are other diseases lurking in the shadows? And what can we do about it? In today’s podcast, our guest Dr. David Batman, a registered medical practitioner in the U.K., discusses how this high level of unprecedented global panic is being intensified by the non-stop media, and specifically, social media. Tune i...
Source: World of Psychology - March 26, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anxiety and Panic General Health-related Interview Podcast The Psych Central Show Source Type: blogs

Virus Crisis Economic FAQ
Arnold Kling1. Why are we so concerned about this virus, which so far (as of mid-March) has killed many fewer people than an ordinary flu?The key to the answer lies in the words “so far.” The virus seems to spread at a phenomenal rate, with cases doubling more than once a week. If the number of deaths were to double once a week, then starting from about 200 deaths on March 15, by the end of May the total would be 200,000 deaths, which is about ten times the number that we get from ordinary flu.The Imperial College papermade an extrapolation that warned of the possibility hundreds of thousands of deaths if social distan...
Source: Cato-at-liberty - March 23, 2020 Category: American Health Authors: Arnold Kling Source Type: blogs

This Will Not Be Over Quickly
Italy provides a glimpse of what’s coming soon to the rest of Europe, the USA, and other parts of the world. Here’s what’s happening in the Italian city of Parma: The intensive care units are now all full. Hospital wards are spilling out into corridors, tents, car parks, gardens and commercial warehouses. We are hearing words – like “triage” – which are usually associated with warfare. Medics and nurses are having to make decisions on which patients to prioritise. Some doctors have died, and others have compared the numbers of admissions to dealing with “an earthquake every day”.Source: ...
Source: Steve Pavlina's Personal Development Blog - March 15, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Source Type: blogs

Hospital Outpatient Visits Drop for First Time; Long History of Similar Inpatient Declines
It is well documented that hospital inpatient admissions have been declining for the past thirty years (see:The Case of the"Disappearing Hospital Beds"; Implications for Pathologists;Inpatient Admissions Decreasing; Implications for Hospital-Based Labs). Now comes news of a decline in outpatient visits (see:Outpatient Visits to Hospitals Decline Year-to-Year for First Time in 35 Years) Below is an excerpt from the article:Thanks to the popularity of urgent care clinics and other non-hospital-based ambulatory care providers, the year-over-year growth in the number of hospital outpatient visits has been on th...
Source: Lab Soft News - February 25, 2020 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Health Wearable Healthcare Delivery Healthcare Innovations Medical Consumerism Quality of Care Telemedicine Source Type: blogs

Podcast: Managing Coronavirus Outbreak Anxiety
Does the new coronavirus from China make you a little anxious? How concerned should we be? Is it a real threat or mostly hype? In today’s podcast, Dr. John Grohol, founder and editor-in-chief of PsychCentral.com, explains what the coronavirus is, how it compares to the flu and why it seems to have hit the panic button in a lot of people. He offers tips to avoid getting sick in general, and importantly, gives advice on how to keep our anxiety levels in check when it comes to new disease outbreaks, especially in how we seek information from the media. If you’d like to learn more about the coronavirus and how to deal wi...
Source: World of Psychology - February 13, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anxiety and Panic Disorders General Health-related Interview Podcast The Psych Central Show Source Type: blogs