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Infectious Disease: Epidemics

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Top stories in health and medicine, December 19, 2014
From MedPage Today: High-Dose Flu Vaccine Better for Frail Elderly. For frail older people living in long-term care, a high-dose inactivated influenza vaccine is a better option than the standard drug. Look into SGLT2 Fracture Risk, Researchers Urge. Look deeper into the potential relationship between SGLT2 inhibitors and bone fractures. JIA Parents Lose Significant Work Time. Parents of a child with juvenile rheumatoid arthritis (JIA) missed nearly triple the work hours as parents whose child did not have the disease. Ebola Response on Track: WHO. The response to the Ebola epidemic is on track to meet U.N. targets. You...
Source: Kevin, M.D. - Medical Weblog - December 19, 2014 Category: Journals (General) Authors: Tags: News Diabetes Endocrinology Infectious disease Rheumatology Source Type: blogs

Struggling with Diabetes? You’re Not Alone
If you know someone with diabetes, you know how much disruption, discomfort and inconvenience it can cause: dietary restrictions to control blood sugar, frequent finger pricks to monitor glucose levels, injections to deliver insulin and the constant fear that your levels will spike or plummet. All of this effort is necessary to manage the ubiquitous disease. Not managing it well or ignoring it could cause a seizure, a coma, or some other truly unpleasant side effects of irregular blood sugar levels. While the most extreme health issues have been widely known for type 1 diabetes, more Americans are being sucked into sedenta...
Source: Disruptive Women in Health Care - November 19, 2014 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Chronic Conditions Source Type: blogs

Ebola! But don’t forget about the flu.
Ebola virus has grabbed headlines since the epidemic started in West Africa nearly a year ago. The death toll is estimated at 4,500 people, and the epidemic continues to spread. One person infected in Liberia returned to Texas with the disease and died, infecting maybe 2 health care workers. Continue reading ... Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - October 31, 2014 Category: Journals (General) Authors: Tags: Physician Infectious disease Source Type: blogs

Ebola Deaths in Perspective
Recent events in West Africa have largely eclipsed several other ongoing outbreaks on the global stage. For example, over 780,000 cases of Chikungunya have been reported in the western hemisphere in recent months, including 1,371 cases in the United States (vs. only 4 of Ebola). Obviously, the severity of Ebola far outweighs that of Chikungunya; thus, the ratio of reported Chikungunya cases to Ebola cases (772,069 / 10,141) is 76-to-1, the ratio of Ebola deaths to Chikungunya deaths (4,922 / 118) is 73-to-1. Sadly, one ongoing epidemic which is more severe than Ebola in both disease numbers and mortality, receives little n...
Source: GIDEON blog - October 28, 2014 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Epidemiology Events General Outbreaks ProMED Ebola Influenza SARS Source Type: blogs

Ebola in the ER: What you should and shouldn’t worry about
As an ER doctor, right now I’m thinking a lot about Ebola — it’s in the news, in my inbox, and in questions from my patients.  Whether it’s an outbreak, a flu epidemic, or a bombing — we in the ER see them first, and so I’m always thinking about how we’ll be ready. So, what concerns me, and what doesn’t? Continue reading ... Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - October 13, 2014 Category: Journals (General) Authors: Tags: Conditions Emergency Infectious disease Source Type: blogs

Ebola Update
Trends-in-Medicine is offering updates on Ebola, which recently has shown up inside the United States. We don’t normally cover this type of story on Policy and Medicine, but found Lynne Peterson’s articles to provide important information from the Centers for Disease Control and Prevention (CDC). CDC itself is providing daily updates as well, and we have offered some additional coverage of the latest news about Ebola’s spread into the United States. On October 2, the CDC confirmed that the first case of this strain of Ebola outside of Africa has been diagnosed, and that patient is in Dallas, Texas. The New York Times...
Source: Policy and Medicine - October 3, 2014 Category: American Health Authors: Thomas Sullivan Source Type: blogs

Could the Ebola virus epidemic have been prevented?
The cover of this week’s issue of Businessweek declares that ‘Ebola is coming’ in letters colored like blood, with the subtitle ‘The US had a chance to stop the virus in its tracks. It missed’. Although the article presents a good analysis of the hurdles in developing antibody therapy for Ebola virus infection, the cover is overstated. Why does Businessweek think that Ebola virus is coming to the US? (there is no mention of this topic in the article). Are we sure that antibody therapy would have stopped the outbreak? (no, as stated in the article). How the U.S. Screwed Up in the Fight Against Ebola is an analysi...
Source: virology blog - September 30, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Information antiviral ebola virus ebolavirus epidemic monoclonal antibody therapy outbreak vaccine West Africa ZMapp Source Type: blogs

Transmission of Ebola virus
As the West African epidemic of Ebola virus grows, so does misinformation about the virus, particularly how it is transmitted from person to person. Ebola virus is transmitted from human to human by close contact with infected patients and virus-containing body fluids. It does not spread among humans by respiratory aerosols, the route of transmission  of many other human viruses such as influenza virus, measles virus, or rhinovirus. Furthermore, the mode of human to human transmission of Ebola virus is not likely to change. What is aerosol transmission? Here is a definition from Medscape: Aerosol transmission has been ...
Source: virology blog - September 27, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information aerosol airborne droplet ebola virus ebolavirus epidemic outbreak respiratory mucosa transmission viral West Africa Source Type: blogs

Vaccine anxiety… A teachable moment for doctors?
I’ve read and re-read Dr. Paul Offit’s WSJ opinion piece, The Anti-Vaccination Epidemic. Dr. Offit is a professor of Pediatrics at a leading hospital in the United States. He is also an author, a scientist, and a vaccine-developer. In short, he is a major physician leader. I’ll come back to that point in just a second. His piece addresses the problem of pediatric infectious disease in the United States. Context is important here. Data from the CDC show that infectious disease is not in the top-five causes of death in children. In the US, children older than one are ten times more likely die from unin...
Source: Dr John M - September 26, 2014 Category: Cardiology Authors: Dr John Source Type: blogs

What we are not afraid to say about Ebola virus
In a recent New York Times OpEd entitled What We’re Afraid to Say About Ebola, Michael Osterholm wonders whether Ebola virus could go airborne: You can now get Ebola only through direct contact with bodily fluids. If certain mutations occurred, it would mean that just breathing would put one at risk of contracting Ebola. Infections could spread quickly to every part of the globe, as the H1N1 influenza virus did in 2009, after its birth in Mexico. Is there any truth to what Osterholm is saying? Let’s start with his discussion of Ebola virus mutation: But viruses like Ebola are notoriously sloppy in replicating, me...
Source: virology blog - September 19, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information aerosol transmission airborne transmission ebola virus evolution hemorrhagic fever Michael Osterholm mutation viral Source Type: blogs

In-flew-enza
Wow, here's the story of how the great flu epidemic of 1918 started in Boston:One this day in 1918, two sailors housed at Boston's Commonwealth Pier reported to sickbay. The men were the first Americans stricken with a strain of influenza that would prove far more dangerous than the German army. By the end of the week, 100 new cases a day were being reported among the sailors at the pier. The disease spread with terrifying speed through both the military and civilian populations. In the next 24 weeks, the epidemic would affect more than 25,000,000 Americans. More than 675,000 would not survive the illness. The flu would ta...
Source: Running a hospital - August 27, 2014 Category: Health Managers Source Type: blogs

Ebolavirus vaccines and antivirals
As the epidemic of Zaire ebolavirus in Western Africa continues (1,779 cases and 961 deaths in four countries), many are questioning why there are no means of preventing or stopping infection. In the past two decades there has been substantial research into developing and testing active and passive vaccines and antiviral drugs, although none have yet been licensed for use in humans. Using antibodies to treat infection with ebolaviruses with antibodies is probably the best known therapy, because it was used to treat a two Americans who were infected while working in Liberia. They received a mixture of three monocl...
Source: virology blog - August 8, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral ebola virus ebolavirus filovirus Guinea hemorrhagic fever Liberia monoclonal antibody therapy Sierra Leone vaccine ZMapp Source Type: blogs

TWiV 285: Hokies go viral
On episode #285 of the science show This Week in Virology, Vincent meets up with XJ Meng and Sarah McDonald at Virginia Tech to talk about their work on viruses of swine and rotaviruses. You can find TWiV #285 at www.twiv.tv.
Source: virology blog - May 18, 2014 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology anellovirus circovirus coronavirus gastroenteritis hepatitis e virus porcine epidemic diarrhea virus rotavirus torque teno virus viral Source Type: blogs

Deadly Medicines and Organised Crime: a review
This is a web version of a review of Peter Gotzsche’s book. It appeared in the April 2014 Healthwatch Newsletter. Read the whole newsletter. It has lots of good stuff. Their newsletters are here. Healthwatch has been exposing quackery since 1989. Their very first newsletter is still relevant. Most new drugs and vaccines are developed by the pharmaceutical industry. The industry has produced huge benefits for mankind. But since the Thatcherite era it has come to be dominated by marketing people who appear to lack any conscience. That’s what gave rise to the Alltrials movement. It was founded in January 2013...
Source: DC's goodscience - April 16, 2014 Category: Science Authors: David Colquhoun Tags: Academia badscience Big Pharma blogosphere Martin Keller Peter Gotzsche Pharmaceutical Industry Richard Eastell Source Type: blogs