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Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Thinking about a post-pandemic world
I've been trying to think carefully about what our world will be like once the current pandemic is over. Most people are rightly focused on the current situation and on short term measures to limit the spread of the virus and the harm it causes, but we should also be thinking about, and planning for, what the world is likely to be like once populations reach some sort of equilibrium. How many people will the virus be infecting or killing every year? How much difference will a vaccine really make? Will we still need to wear masks? What follows is my non-rigorous back-of-the-envelope analysis.&nb...
Source: RRResearch - July 19, 2020 Category: Molecular Biology Authors: Rosie Redfield Source Type: blogs
Efforts Continue to Use COVID-19 as a Learning Moment Regarding the Costs of Aging
Near everyone who dies from the SARS-Cov-2 virus responsible for the COVID-19 pandemic is old. The old are vulnerable firstly because their immune systems are much diminished in effectiveness, and secondly because the state of chronic inflammation characteristic of old age makes the cytokine storm that causes much of the SARS-Cov-2 mortality more likely and more severe.
Members of the medical research community focused on intervention in the aging process - a way to treat all age-related conditions by addressing their underlying causes - are attempting to use the attention given to COVID-19 to educate the public and...
Source: Fight Aging! - July 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Trump COVID Legacy: Bad Timing. Lots of Questions. Few Answers.
By MIKE MAGEE, MD
What a strange irony. Trump decides, full-bravado, to challenge China to a trade war just months before China unwittingly hatches a virulent pandemic that collapses our deeply segmented health care system and our economy simultaneously. And rather than cry “Uncle”, our President then fires the WHO just as their experts are heading to China to attempt to unravel the mystery of COVID-19.
With the ongoing, cascading catastrophe of Trump’s mishandling of COVID-19, it is easy to lose sight that the next pandemic (fueled by global warming, global trade, and human and animal migration) is just around...
Source: The Health Care Blog - July 16, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Politics Mike Magee Trump Source Type: blogs
TWiV 636: Georgia State viral
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Click arrow to playDownload TWiV 636 (68 MB .mp3, 113 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - July 9, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral drug ebolavirus IFN immune modulation influenza virus innate immunity measles virus respiratory syncytial virus rotavirus viruses Source Type: blogs
Early guidance on the 2020/21 Seasonal Influenza Vaccination Advanced Service
Pharmaceutical Services Negotiating Committee -This briefing provides early guidance for community pharmacy contractors and their teams on the 2020/2021 NHS Seasonal Influenza Vaccination Advanced Service in England. It also highlights the potential scenarios being discussed that may provide additional opportunities to provide the community pharmacy flu vaccination service in other environments. This information can be used to plan provision of a Covid-safe service.BriefingPharmaceutical Services Negotiating Committee - press release
Source: Health Management Specialist Library - July 8, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: Local authorities, public health and health inequalities Source Type: blogs
A public health update on COVID-19 PODCAST
“Over the last 100 years, the U.S. has had to respond to five avian flu pandemics. The most severe was the 1918 avian influenza infecting 1/3 of the world ’s population and killing 650,000 Americans. It was also the last time wide-spread containment, mitigation, and isolation strategies were used in the U.S. Seldom mentioned about the […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - July 5, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast COVID-19 coronavirus Infectious Disease Public Health & Policy Source Type: blogs
TWiV 634: 1000 hours of the sunlight of TWiV
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Click arrow to playDownload TWiV 634 (72 MB .mp3, 120 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - July 2, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus COVID-19 FDA vaccine guidance Operation Warp Speed SARS-CoV-2 viral viruses Source Type: blogs
I Joined Twitter to Teach
I joined Twitter to teach. In May 2016, I started tweeting “questions of the day” for my inpatient hospital medicine team at Thomas Jefferson University Hospital from @RJmdphilly. #GreenQOD (“Green” is our teaching service, and “QOD” for question of the day) was born in the days of only 140 characters per tweet (now expanded to 280), which placed a potentially daunting onus on brevity in phrasing—and answering—clinical questions.
My inaugural question? “What’s the real story with beta blockers in reactive airway disease? If increase risk is real, how do you balance risk/benefit?”
Rules of t...
Source: Academic Medicine Blog - June 30, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective social media teaching Twitter Source Type: blogs
Breathalyzer to Detect COVID-19 in Seconds
Being able to tell, in a matter of seconds, whether someone is infected with the virus that causes COVID-19 would certainly help put a halt to the ongoing pandemic. Existing tests typically involve a deep nasal swab to obtain enough fluid sample, whi...
Source: Medgadget - June 10, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Medicine Pathology Public Health Source Type: blogs
Planning for Future Pandemics Including Smallpox Outbreaks: Interview with Dr. Phil Gomez, CEO, SIGA Technologies
The COVID-19 pandemic has had significant global consequences, with healthcare systems stretched to their limits, a growing death toll, and economic devastation as economies came grinding to a halt.
The pandemic
and its aftereffects will be with u...
Source: Medgadget - May 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Public Health Source Type: blogs
Microfluidic Test for Viral Antibodies Takes Just 20 Minutes
Researchers at Hokkaido University in Japan have developed a microfluidic test that can detect antibodies against a viral infection. So far, the test has been optimized to detect avian flu, but could be adapted to detect antibodies against the virus ...
Source: Medgadget - May 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Materials Medicine Public Health Source Type: blogs
How to Practice High-Quality Telemedicine in the Era of COVID-19
By ANISH MEHTA, MD
My practice received its first question about coronavirus from a patient on January 28, 2020. Though there were over 200 deaths reported in China by that time, no one could have imagined how drastically this would come to disrupt our lives at home.
Thankfully, I had a head start.
As a doctor at an integrated telemedicine and primary care practice in New York City, nearly two out of every three of my medical encounters that month was already virtual.
I spent much of January caring for patients who had contracted seasonal viruses, like influenza or norovirus (i.e. the stomach flu). My patients ...
Source: The Health Care Blog - May 26, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
