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Infectious Disease: Influenza

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The true death toll
A commenter asks why people don ' t count death certificates to determine the actual number of deaths above the norm, since we can ' t trust the reported Covid-19 deaths. Well, people have done this, and it ' s pretty disturbing. Researchers who did this in Italy found the actual number of excess deaths to be twice the reported rate. In New York and New Jersey, the excess is at least 50%. This can happen because many deaths are not attributed to Covid-19, whether because they are attributed to influenza or pneumonia in the absence of testing, or because the virus can cause symptoms such as stroke and kidney failure, which ...
Source: Stayin' Alive - May 23, 2020 Category: American Health Source Type: blogs

The New Normal is Still Unknown, on Earth as it is in Healthcare
By HANS DUVEFELT, MD From the vantage point of our self-quarantined shrunken universes, we cannot see even the immediate future, let alone what our personal and professional lives will look like some years from now. Factories are closed, luxury department stores are in bankruptcy, hospitals have stopped performing elective procedures and patients are having their heart attacks at home, unattended by medical professionals. New York office workers may continue to work from home while skyscrapers stand empty and city tax revenues evaporate. Quarantined and furloughed families are planting gardens and cooking at h...
Source: The Health Care Blog - May 22, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Hans Duvefelt Source Type: blogs

Better Vaccines for Older People are a Poor Alternative to Better Immune Systems for Older People
The paper here offers a good overview of recent research and development aimed at improving the effectiveness of vaccines in old people. Vaccines are only poorly effective in the old because of the age-related decline of the immune system. A great deal of effort, with only some success, has gone into trying to improve vaccine effectiveness in older populations. Even if tinkering with vaccines boosts the percentage of patients who exhibit an immune response, however, that response is always going to be more anemic than that of a younger person, given the effects of aging on the immune system. This time and funding would per...
Source: Fight Aging! - May 20, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

And now for some good news on health
When it comes to health concerns, the COVID-19 pandemic is top of mind for most people right now. And that’s for good reason. But there is some very good non-COVID health news that may not be getting the attention it deserves. According to the CDC, the rates of six of the top 10 causes of death in this country, which account for about three-quarters of all deaths, have been declining. That’s remarkable. And these improvements are occurring despite an aging population and an obesity epidemic that affects several health conditions. Six positive health trends Let’s look at the trends in these conditions and their rank ...
Source: Harvard Health Blog - May 15, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cancer Health Health trends Heart Health Source Type: blogs

Caring for Babies and Small Children During COVID-19
The good news is emerging evidence shows that coronavirus affects children and babies the least out of all age groups. While there have been a small number of newborns who have contracted the disease, it is extremely rare. In these cases, it’s impossible to tell, as yet, if the virus was contracted in utero, or shortly after birth. Babies and COVID: The Breastfeeding Question Many mothers are wondering if they should continue breastfeeding if they are showing symptoms of illness. Traditionally, in cases of common influenza, encouraging a baby to breastfeed even when the mother is sick has the effect of increasing immunit...
Source: Conversations with Dr Greene - May 11, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Source Type: blogs

The hardest data
There is always a certain amount of slop in attribution of causes of death. Actually those annual influenza death rates that are talked about so much are estimates, because in ordinary times most people with respiratory infections aren ' t lab tested to confirm the pathogen. Death certificates might just say pneumonia. But enough tests are done to be able to extrapolate. Covid-19 is different in that people who present at the hospital with serious symptoms are tested, so a much higher proportion of deaths are laboratory confirmed. However, some states are only reporting laboratory confirmed deaths, and people who die at ho...
Source: Stayin' Alive - May 11, 2020 Category: American Health Source Type: blogs

The dimension of time
It is very puzzling how many reporters, commentators and politicians don ' t seem to get the basic idea that an epidemic has a temporal dimension. They will write something to the effect that a policy failure has resulted in the death of 60,000 Americans, and by the time the piece is published the number is 66,000. The front page of the New York Times today says that nearly 80,000 Americans have died, but as I write this at 8:40 AM the officially reported number is 80,678 and by the time you read this it will be more.The most bizarre use of this elimination of the dimension of time was back when people were saying things l...
Source: Stayin' Alive - May 11, 2020 Category: American Health Source Type: blogs

SENS Research Foundation on COVID-19 and Aging
SENS Research Foundation here explains why COVID-19, like near all infectious disease, is far worse for the old. It isn't just a matter of the decline of immune function, though that is the bulk of it. Older people have a greater burden of damage and dysfunction that makes them less resilient in many other ways. Rising mortality due to infectious disease with age is the result of both (a) a greater likelihood of severe infection due to immune aging, and (b) that the individual is less likely to survive a severe infection due to general frailty. Tens of thousands die every year in the US from seasonal influenza; that is lar...
Source: Fight Aging! - May 11, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19: Physicians in Shackles
By ANISH KOKA, MD A number of politically tinged narratives have divided physicians during the pandemic. It would be unfortunate if politics obscured the major problem brought into stark relief by the pandemic: a system that marginalizes physicians and strips them of agency. In practices big and small, hospital-employed or private practice, nursing homes or hospitals, there are serious issues raising their heads for doctors and their patients. No masks for you When I walked into my office Thursday, March 12th, I assembled the office staff for the first time to talk about COVID.  The prior weekend had been awa...
Source: The Health Care Blog - May 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Anish Koka medical autonomy Pandemic Source Type: blogs

The False Choice Between Science And Economics
This article originally appeared on The Bulwark here. The post The False Choice Between Science And Economics appeared first on The Health Care Blog.
Source: The Health Care Blog - May 1, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy David Shaywitz Source Type: blogs

The Science of Infectious Disease Modeling
What Is Computer Modeling and How Does It Work? Recent news headlines are awash in references to “modeling the spread” and “flattening the curve.” You may have wondered what exactly this means and how it applies to the COVID-19 pandemic. Infectious disease modeling is part of the larger field of computer modeling. This type of research uses computers to simulate and study the behavior of complex systems using mathematics, physics, and computer science. Each model contains many variables that characterize the system being studied. Simulation is done by adjusting each of the variables, alone or in combination, to ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 29, 2020 Category: Research Authors: Chrissa Chverchko Tags: Injury and Illness Tools and Techniques Computational Biology Cool Tools/Techniques Diseases Modeling Source Type: blogs

Strategies for lifting COVID-19 mitigation restrictions
Over the last 100 years, the U.S. has had to respond to five avian flu pandemics. The most severe was the 1918 avian influenza infecting 1/3 of the world ’s population and killing 650,000 Americans. It was also the last time wide-spread containment, mitigation, and isolation strategies were used in the U.S. Seldom mentioned about the […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - April 28, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/nicolas-k-fletcher" rel="tag" > Nicolas K. Fletcher < /a > < /span > Tags: Policy COVID-19 coronavirus Infectious Disease Public Health & Source Type: blogs

COVID-19 in the Context of Aging
It is widely appreciated that old people have a poor time of it when it comes to infectious disease. Seasonal influenza kills tens of thousands of older people every year in the US alone. The aged immune system functions poorly, and vaccinations for many conditions have low success rates in older people. Thus the vast majority of COVID-19 deaths are old people exhibiting immunosenescence. Given that the world at large seems to be entirely accepting of the yearly toll of influenza, while COVID-19 is classed as an apocalypse of some sort, one has to wonder how much of the hysteria surrounding COVID-19 stems from the rare - b...
Source: Fight Aging! - April 28, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs