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Infectious Disease: Influenza
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Total 929 results found since Jan 2013.
TWiV 931: Driven to immunodistraction
TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.
Source: virology blog - August 28, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology broadly neutralizing antibody influenza virus neurovirulence nOPV2 poliovirus vaccine viral viruses wastewater Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - August 23, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon.-----h...
Source: Australian Health Information Technology - August 23, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
60 year old with vomiting, diarrhea, and syncope: is this Wellens? Is this type 2 MI?
Written by Jesse McLaren, with edits/comments by Smith and Grauer A 60 year-old patient with diabetes and ESRD presented with 24 hours of vomiting, diarrhea, weakness and then a syncopal episode. Vitals: RR 18, sat 98%, HR 103, BP 124/71 and temp 38.0. Here ’s their ECG: is this Wellens? There ’s borderline sinus tach, normal conduction, normal axis, and low voltages in the limb leads. The anterior leads have loss of R waves, mild convex ST segments and primary T wave inversion. In the context of QS waves, T wave inversion indicates old or subacute infarct, or reperfusion after signif icant infarc...
Source: Dr. Smith's ECG Blog - August 19, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Weekly Australian Health IT Links – 15 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Interesting to see ongoing funding for the #myHR announced to help Accenture keep is all going. Not sure why?Lots of NBN news with the Annual Report released.-----https://itwire.com/business-it-news/security/ransomware-attacks-on-the-rise-report.htmlThursday, 11 August 2022 15:33Ransomware attacks on the rise: reportBy Staff Write...
Source: Australian Health Information Technology - August 15, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Nihilistic AAP Bronchiolitis Guidelines
Not only has the COVID-19 pandemic killed millions of people, but it has also caused disruptions in every imaginable aspect of our lives. One has been the seasonality of other diseases like influenza and respiratory syncytial virus infection. RSV infection is typically a winter disease, but here we are in the summer months and our pediatric emergency department is flooded with infants infected with RSV.I expressed concern about the 2014 American Academy of Pediatrics bronchiolitis guidelines three years ago. (EMN. 2019;41[1]:31; http://bit.ly/2TlwNj9.) Those comments have proven to have real-life clinical releva...
Source: M2E Too! Mellick's Multimedia EduBlog - August 5, 2022 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Aging and the Severity of Inflammatory Infectious Disease Such as SARS-CoV-2
This article provides a pathophysiologic view of COVID-19 in older adults within the frame of inflammaging, with a focus on antiinflammatory treatments for acute and postacute disease.
How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 disease, independently from the presence of preexisting diseases. The COVID-19 mortality risk sharply increases for elderly subjects, as showed by the reports of China, Italy, and the United States. In particular, in Italy, case fatality rate for patient a...
Source: Fight Aging! - August 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Weekly Australian Health IT Links – 1 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot this week – especially regarding the NBN and Labor trying to regain control of what it is actually for – service provision – and not making a huge profit – in their view. Love the new Minister has ambitions to be maximally photogenic and not a ‘techie’!Otherwise all sorts of fun things!-----https://www.ausd...
Source: Australian Health Information Technology - August 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
FDA Wisely Permits Pharmacists to Prescribe Paxlovid
Jeffrey A. SingerWhen the Food and Drug Administration granted Emergency Use Authorization to the antiviral drugs Paxlovid and monupiravir in the beginning of this year, I co ‐authored anoped in the New York Daily News, along with Josh Bloom of the American Council on Science and Health, complaining about, among other things, the FDA ’s requirement that a patient who tests positive for COVID must get a prescription from a doctor, nurse practitioner, or physician assistant to obtain the drug. For the drugs to be effective they must be started within five days of the start of COVID symptoms. Not ev...
Source: Cato-at-liberty - July 7, 2022 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines.
Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Influenza Vaccination Associated with a 40% Reduced Risk of Alzheimer ' s Disease
Researchers here note a sizable reduction in Alzheimer's disease risk in that part of the aged population that receives influenza vaccines. There is the usual question as to whether vaccination is a proxy for conscientiousness in health matters throughout later life, but here the focus is on biological mechanisms that might explain the effect. The most plausible to my eyes is the phenomenon of trained immunity, in which vaccination for a specific pathogen can provoke a general improvement in all functions of the innate immune system. This improvement includes reduced inflammation, and the chronic inflammation of aging is c...
Source: Fight Aging! - July 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Flu Is Making Comeback. Here ’s What We Can Do About It
Jeffrey A. SingerAfter being nearly absent in 2020 and 2021, influenza cases are making a comeback. In fact, cases are up ‐tickingunusually late in the year. The Centers for Disease Control and Prevention (CDC)reported on April 15 that the majority of cases are H3N2, “antigenically different from the vaccine reference viruses.” This explains why the latest flu vaccine is only16 percent effective in reducing the chances of a moderate to severe infection. As of April 15, the CDC reported at least 4.3 million flu illnesses, 42,000 hospitalizations, and 2,500 deaths from the flu.Public health experts attribu...
Source: Cato-at-liberty - April 18, 2022 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
TWiV 887: Bonfire of the monocytes
TWiV explains why this season's influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
Source: virology blog - April 10, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody dependent enhancement coronavirus COVID-19 Fc receptor fucosylation glycosylation H3N2 inflammation influenza vaccine pandemic SARS-CoV-22 viral viruses Source Type: blogs
Lymphoid Follicle Chip Models Complex Immune Responses
Researchers at the Harvard Wyss Institute have created a microfluidic chip that contains lymphoid follicle-like structures, allowing them to model complex immune responses to various pathogens and vaccines. The breakthrough could let scientists to mo...
Source: Medgadget - March 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Pathology Public Health Source Type: blogs
More on why we Stay Alive
A couple of days ago I referred to the doubling of human life expectancy in 100 years, and the importance of pasteurization of milk in making that happen. Our next installment is about water. There ' s nothing more basic than good old H2O, but it used to kill city dwellers about as often as milk. People actually figured this out even before Pasteur and Koch came up with the germ theory of disease.Cholera is an intestinal infection caused by a bacterium called Vibrio cholera, which is spread through contaminated water or food. The disease causes severe diarrhea that can last for several days. Depending on the strain of bact...
Source: Stayin' Alive - March 21, 2022 Category: American Health Source Type: blogs
