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Infectious Disease: Influenza
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Gain of function research explained
The term ‘gain of function’ is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an organism a new property or […]
Source: virology blog - September 10, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology avian influenza virus coronavirus COVID-19 ferret gain of function research GOF pandemic viral viruses Source Type: blogs
Selfish Much?
By KIM BELLARD
In a week where we’ve seen the bungled Afghan withdrawal, had Texas show us its contempt for all sorts of rights, watched wildfires ravage the west and Ida wreak havoc on a third of the country, and, of course, witnessed COVID-19 continue its resurgence, I managed to find an article that depressed me further. Thank you, Aaron Carroll.
Dr. Carroll – pediatrician, long-time contributor to The New York Times, and now Chief Health Officer of I.U. Health — wrote a startling piece in The Atlantic: We’ve Never Protected the Vulnerable. He looks at the resistance to public health measur...
Source: The Health Care Blog - September 7, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy health equity Kim Bellard Source Type: blogs
Fight Aging! Newsletter, August 30th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out mo...
Source: Fight Aging! - August 29, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Here Come the Workplace Vaccine Religious Exemption Battles
Walter OlsonCompanies like Wal ‐Mart, United Air Lines, and Tyson Foods have announced plans to require part or all of their workforce to be vaccinated against COVID-19. Many employee claims for religious exemptions are likely to follow. How are they likely to fare as a legal matter?InApril I wrote:Title VII, the federal employment discrimination law, forces an employer to accommodate employees ’ religious beliefs when it can do so without cost. For that reason, employees with religious objections to vaccination can ask employers to exempt them, and employers must at least consider the request. “Consider...
Source: Cato-at-liberty - August 25, 2021 Category: American Health Authors: Walter Olson Source Type: blogs
Age-Related Dysfunction in Cellular Metabolism Substantially Impacts the Immune System
Most of what to my eyes are less promising lines of research into the treatment of aging are focused on manipulation of cellular metabolism. These approaches, such as targeting the mTOR pathway, largely derive from the study of calorie restriction and the cellular response to stress that is brought on by lack of nutrients. Calorie restriction extends average and maximum life span considerably in short-lived species, up to 40% in mice, for example. It increases the efficiency of cellular maintenance processes and makes cells more frugal in other ways. The impact of aging is slowed, as molecular damage accumulates less rapid...
Source: Fight Aging! - August 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
COVID ’s lab leak theory obscures zoonosis and progression
Even as COVID-19 is found in apes, big cats, minks, domestic cats, other small mammals, and now in U.S. deer, some don ’t want to let go of the insultingly simplistic “lab leak” theory. Do they really think the 1918 influenza and AIDS pandemics (or Ebola, MERS, and SARS ) needed lab mendacity to exist? WeRead more …COVID’s lab leak theory obscures zoonosis and progression originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - August 7, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/martha-rosenberg" rel="tag" > Martha Rosenberg < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
Vaccine associated myocarditis revisited with COVID-19 mRNA vaccines
When I had reviewed the topic of vaccine associated myocarditis for an editorial in the BMH Medical Journal in 2017, most of the cases were associated with small pox vaccination [1]. There were also reports of streptococcal pneumonia vaccine and influenza vaccine associated myocarditis. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) used in the vaccine were also implicated in some cases [2,3].
While the large scale vaccination for small pox in an attempt to prepare for potential bioterrorism was the association in 2003 [4], COVID-19 mRNA vaccines are currently in the limelight for vaccine induced myocarditis...
Source: Cardiophile MD - July 22, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Covid-19: preparing for the future - looking ahead to winter 2021/22 and beyond
This report warns that a mix of Covid-19, influenza, and the respiratory virus Respiratory Syncytial Virus, could push the NHS to breaking point this winter unless action is taken. The report urges policy makers and the NHS to prepare by expanding Covid-19 testing, increasing the speed and uptake of the Covid-19 vaccination, and strenthgened financial and staffing support.ReportThe Academy of Medical Sciences - news
Source: Health Management Specialist Library - July 15, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Covid-19 NHS performance and productivity Source Type: blogs
AI-Powered App Interprets HIV Test Results
This study is a really strong partnership with AHRI that demonstrates the power of using deep learning to successfully classify ‘real-world’ field-acquired rapid test images, and reduce the number of errors that may happen when reading te...
Source: Medgadget - June 22, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Informatics Medicine Public Health Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Yet Again We See A Technologically Ignorant Government Breaking Basic Information Management Rules!
This appeared last week: Clarity on COVID immunisation status on My Health Record The ADHA has issued new guidance to ensure patient records are correctly linking with up-to-date immunisation data. Morgan Liotta 10 Jun 2021 Recent upgrades to My Health Record(MHR) include a new consolidated view of immunisation details from the Australian Immunisation Register (AIR) and the individual ’s record, making it easier for healthcare providers to view their patients’ information.
To support the Australian Government ’s COVID-19 vaccination rollout, data from all states and territories is now flowing into MHR. Healthc...
Source: Australian Health Information Technology - June 18, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Details on the Failed Phase 3 Trial of the resTORbio mTORC1 Inhibitor
The short version of the story regarding the failure of resTORbio's phase 3 trial of an mTORC1 inhibitor targeting immune function and influenza infection in old people is that the FDA forced a last minute change of the phase 3 endpoint from the phase 2 endpoint of a reduction in clinically confirmed infections to a more nebulous outcome of whether or not people reported feeling better. Which is far from the worst offense that FDA staff have committed in the course of hindering the adoption of new medical technologies, but it is illustrative of the obstacle that regulators pose. We can all speculate as to what was going on...
Source: Fight Aging! - June 16, 2021 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
In pursuit of health equity and the state of U.S. healthcare
Between 2014 and 2015, death rates increased for eight of the 10 leading causes; only death rates caused by cancer fell, and mortality rates for influenza and pneumonia stayed flat.
Source: Healthcare IT News Blog - June 15, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inflammaging and Disruption of Coagulation as Contributions to High COVID-19 Mortality in the Old
The burden of infectious disease falls most heavily upon the old. The attention given to COVID-19 has highlighted that point, though much of the media seems determined to avoid talking about the fact that near all mortality due to the condition occurs in the old and the cormorbid. It is nothing new, of course. Influenza kills tens of thousands of old people every year in the US alone, without much attention given to it. That the elderly suffer and die is old news. It is, however, old news that we should revisit in this era of revolutionary progress in medical biotechnology. The causes of aging and age-related mortality are...
Source: Fight Aging! - June 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
