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Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Proposal to Improve Healthcare and Make It More Affordable
By STEVE ZECOLA Americans spend about $3 trillion per year on healthcare, or about $10,000 per person per year. Despite these expenditures, Americans are worse off than their international counterparts with respect to infant mortality, life expectancy and the prevalence of chronic conditions. In policy debates, Republicans mostly prefer to let the marketplace devise the appropriate outcomes, but this approach ignores the market failures that plague the industry. On the other hand, Democrats propose a variety of solutions such as “Medicare for All” which nationalizes all healthcare insurance or, as a variant, â...
Source: The Health Care Blog - August 6, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medicare For All Source Type: blogs

Why Don ’t Digital Health Investors Finance Solutions To Tough Medical Issues?
Why did activity trackers flood the digital health market, while there’s barely a company dealing with menopause, arthritis, or rare diseases? How do digital health investors decide when it comes to funding a new project, and what are the specific factors to take into account in relation to the healthcare market? We looked around what could scare off financiers from funding tough medical issues, and have a suggestion on how to bring forward solutions for marginalized health problems. Read on. Investment in digital health for everyone? Investment in healthcare, especially in the digital health market, is growing ste...
Source: The Medical Futurist - August 3, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine companies company digital digital health digital health startups finance funding Healthcare investment technology Source Type: blogs

Why Don ’t Digital Health Investors Finance Tough Medical Issues?
Why did activity trackers flood the digital health market, while there’s barely a company dealing with menopause, arthritis, or rare diseases? How do digital health investors decide when it comes to funding a new project, and what are the specific factors to take into account in relation to the healthcare market? We looked around what could scare off financiers from funding tough medical issues, and have a suggestion on how to bring forward solutions for marginalized health problems. Read on. Investment in digital health for everyone? Investment in healthcare, especially in the digital health market, is growing ste...
Source: The Medical Futurist - August 3, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine companies company digital digital health digital health startups finance funding Healthcare investment technology Source Type: blogs

Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Commentary on the Developing UK Government Position on Healthy Longevity
One option for patient advocacy for the treatment of aging as a medical condition is to petition governments and large international organizations such as the World Health Organization to adjust their positions on research funding and goals in medicine. This a fairly popular path, for all that I think it not terribly effective at speeding up the cutting edge of research and development. Large organizations of any sort are inherently conservative, and tend to get meaningfully involved in new fields of human endeavor only long after their support would have been truly influential. Nonetheless, numerous examples of gov...
Source: Fight Aging! - July 26, 2019 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs

p53, Hsp90 β, and Cellular Senescence in Muscle Regeneration and Muscle Aging
Senescent cells are a mechanism of aging, but also a mechanism of regeneration. When entering a senescent state, a cell shuts down replication and begins to secrete a mix of inflammatory and other signals, rousing the immune system and altering the behavior of surrounding cells. In addition to the other ways in which cells become senescent, in response to the Hayflick limit on cellular replication, or to potentially cancerous DNA damage, senescent cells also arise in response to injury. Their secretions help to guide the complicated dance of immune cells, stem cells, and somatic cells that takes place during the consequent...
Source: Fight Aging! - July 24, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cannabis and cannabinoids for persistent pain?
Over the last 12 months New Zealanders have entered into the debate about cannabis and cannabinoids for medical use. In the coming year we’ll hear even more about cannabis as we consider legalising cannabis for recreational use. There is so much rhetoric around the issue, and so much misinformation I thought it high time (see what I did there?!) to write about where I see the research is at for cannabis and cannabinoids for persistent pain. For the purposes of this blog, I’m going to use the following definitions: Cannabis = the plant; cannabis-based medication = registered extracts (either synthetic or from...
Source: HealthSkills Weblog - July 21, 2019 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping strategies Research Science in practice cannabinoids cannabis medicinal cannabis neuropathic pain persistent pain recreational cannabis Source Type: blogs

Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Notes on the 2019 Ending Age-Related Diseases Conference in New York
I recently attended the second Ending Age-Related Diseases conference in New York, hosted by the Life Extension Advocacy Foundation (LEAF). The mix of attendees was much the same as last year: an even split between scientists, entrepreneurs, investors, patient advocates, and interested onlookers, all focused on the treatment of aging as a medical condition. The presentations were similarly a mix of scientists talking about their research programs, entrepreneurs presenting on the data produced by their companies, and investors discussing the state of the industry. For my part, I have already presented several times t...
Source: Fight Aging! - July 17, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

OncoSenX Raises $3 Million to Adapt the Oisin Biotechnologies Platform to Cancer
Oisin Biotechnologies uses a form of programmable suicide gene therapy to target senescent cells for destruction. The therapy can be triggered by expression of specific genes inside a cell, and so beyond senescent cells there is a long, long list of possibly harmful cell populations in aging and disease that it would be beneficial to remove. The obvious first choice is cancerous cells with a mutation in one of the common cancer suppressor genes, such that the gene is expressed but not helping. Thus Oisin Biotechnologies spun out OncoSenX last year. The company is moving forward towards trials, and recently raised a seed ro...
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 8th 2019
In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time. Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Us...
Source: Fight Aging! - July 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Top 100 Companies In Digital Health Addressing Real-World Needs
The digital health market is extremely volatile: start-ups show up, promise to disrupt the entire health scene, but go down just as fast having not received the necessary funding. Others change their profiles, partner with big pharma companies or lose the battle with another venture providing a better technology. Not to speak about the hype, buzzwords, and overmarketing, which calls for careful consideration. In spite of all the challenges, The Medical Futurist team is working tirelessly to stay ahead of the turbulent market changes and bring you the Top 100 Companies In Digital Health in an e-book every year. Real-wor...
Source: The Medical Futurist - June 27, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine companies company digital digital health digital health companies digital health market digital technology disruption disruptive Healthcare Innovation needs Source Type: blogs

Evidence for Senescent Cells to Cause Aortic Aneurysms
Cells enter a senescent state in response to molecular damage, a toxic environment, reaching the Hayflick limit on replication, or to aid in wound healing, among other reasons. A senescent cell halts replication and begins to secrete a mix of inflammatory signals, growth factors, and other molecules that influence surrounding cells. This is useful and beneficial when it occurs in potentially cancerous, damaged cells, or as a part of the wound healing process. Normally these cells quickly self-destruct or are destroyed by the immune system. It is when senescent cells evade destruction and linger for the long term that the p...
Source: Fight Aging! - June 26, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs