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Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Upregulation of Autophagy Reverses Age-Related Decline of Memory B Cell Function
Memory B cells undertake some of the more important tasks in coordination of an effective immune response, circulating in the body to accelerate the deployment of other resources in the immune system to tackle a specific threat. Dysfunction in B cells is a significant component of the onset of age-related immunosenescence, the progressively greater incapacity of the immune system. Selectively removing and replacing B cells has been shown to improve matters, but here researchers identify failing autophagy as an important factor. B cells are long-lived, and long-lived cells tend to build up metabolic waste that is resilient ...
Source: Fight Aging! - September 11, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
TWiV 563: BLT on mice
The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens. Click arrow to play Download TWiV 563 (55 MB .mp3, 91 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
Source: virology blog - September 1, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology BLT mouse coronavirus flu vaccine human cytomegalovirus humanized mouse immunodeficient mice influenza lung implant mouse model vaccine effectiveness viral viruses zika virus Source Type: blogs
Guidance on the seasonal influenza vaccination advanced service 2019/20
Pharmaceutical Services Negotiating Committee -This briefing provides guidance for community pharmacy contractors and their teams on the 2019/2020 NHS seasonal influenza vaccination advanced service. It discusses the background to and aims of the service, service provision, which vaccines should be covered and training of staff.BriefingPharmaceutical Services Negotiating Committee - news
Source: Health Management Specialist Library - August 22, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Source Type: blogs
Everyone Is Having the Wrong Healthcare Debate
By STEVEN MERAHN, MD
In 1807, in an effort to spite the British and French for shipping interference (and forced recruitment of American citizens into military service), the United States Congress passed an Embargo Act, effectively shutting down trade with these two countries. Britain and France quickly found other trading partners; the US, then limited in our capacity to sell products outside our borders, was left with a devastated economy and a gaping hole in our face. It took only weeks before Congress passed a loophole; they repealed the act within 15 months of its passing. It was a great lesson in unintended co...
Source: The Health Care Blog - August 16, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Politics Uncategorized Health care debate Health Care Reform Steven Merahn universal healthcare Source Type: blogs
TWiV 560: CEIRS, influenza and company
From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations. Click arrow to play Download TWiV 560 (37 MB .mp3, 61 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes […]
Source: virology blog - August 11, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology CD4 T lymphocytes CEIRS HA stalk influenza influenza virus niaid pediatric influenza universal influenza vaccine viral viruses Source Type: blogs
Cytomegalovirus in the Immunology of Aging
The open access editorial noted here serves as an introduction to some of the current thinking on the role of cytomegalovirus (CMV) in the age-related decline of the immune system. CMV infection is pervasive throughout the population, particularly in the old. This persistent viral infection cannot be effectively cleared by the immune system, and an ever greater percentage of immune cells become uselessly specialized to fight CMV. This leaves ever fewer immune cells ready to tackle other threats. This seems an important component of immune dysfunction, one that can perhaps be addressed by selectively destroying these immune...
Source: Fight Aging! - August 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why do parents worry about vaccines?
We are in the midst of a measles epidemic. As of July 25th, more than 1,100 cases have been reported in 30 states since the beginning of the year. That’s the highest number since 1992 — and since measles was declared eliminated in 2000. Given that measles is extremely contagious — the virus can linger in rooms even after a sick person has left — and can lead to serious complications, this is really alarming.
There is a simple way to help: get more people immunized.
How many children receive vaccines?
Most children in the US are immunized. Only a little more than 1% of children have no immunizations. This is importa...
Source: Harvard Health Blog - August 2, 2019 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Parenting Vaccines Source Type: blogs
Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD.
Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Role of mTOR as a Regulator of Lifespan
The mTOR gene is deeply involved in the regulation of cellular activities in response to nutrient sensing. It is also implicated in the many, many changes that occur to slow aging in response to a restricted calorie intake, including processes known to be important to aging such as mitochondrial function and cellular senescence. Given that most research to date on intervention in the aging process has focused on the calorie restriction response and related upregulation of stress response mechanisms, it is no surprise that mTOR has attracted a lot of attention. The first mTOR inhibitor drugs are already going through clinic...
Source: Fight Aging! - July 23, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
TWiV 557: Congress in Rotterdam
From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Click arrow to play Download TWiV 557 (41 MB .mp3, 67 min) Subscribe (free): iTunes, Google […]
Source: virology blog - July 22, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antigenic drift ebola virus environmental virology epidemic global health H2N2 influenza virus pandemic vaccine viral viruses viruses in water Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Mainstream View of the Longevity Industry
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - July 17, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What ' s new in midwifery - 17th July 2019
Some recent things...Global healthExploring the equity impact of a maternal and newborn health intervention: a qualitative study of participatory women ’s groups in rural South Asia and AfricaBaby ‐Friendly Community Initiative—From National Guidelines to Implementation: A Multisectoral Platform for Improving Infant and Young Child Feeding Practices and Integrated Health ServicesA study in KenyaExpanding the Agenda for Addressing Mistreatment in Maternity Care: A Mapping Review and Gender AnalysisAuditNational Maternity and Perinatal Audit Organisational Report 2019 (HQIP)Second report from this audit. Map...
Source: Browsing - July 17, 2019 Category: Databases & Libraries Tags: midwifery Source Type: blogs
TWiV 554: Full fathom five thy viromes lie
A trio of TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole. Click arrow to play Download TWiV 554 (48 MB .mp3, 79 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - June 30, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ANP32 H1N1 H3N2 influenza drift influenza host range influenza in Australia influenza RNA polymerase influenza vaccine marine viruses metagenomics viral viral communities Source Type: blogs
