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TWiV 550: Covering up the shiny parts
TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Click arrow to play Download TWiV 550 (64 MB .mp3, 105 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - June 2, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antigenic hole broadly neutralizing antibodies epitope herpes simplex virus immunofocusing latency neuronal cell line reactivation universal influenza vaccine viral viruses Source Type: blogs
Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing.
Altered Intercellular Communication
It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Protect, modify, deprotect, and vaccinate
A method for making vaccines that induce antibodies against a specific epitope could be used to produce a universal influenza vaccine that would not have to be changed every year. When we are infected with influenza virus, most of the antibodies we make are directed against the head of the HA molecule (pictured). Amino acids on […]
Source: virology blog - May 31, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information broadly neutralizing antibodies conserved epitope HA stem immunofocusing influenza virus vaccine viral viruses Source Type: blogs
A Dysfunctional T Cell Population Associated with Impaired Vaccination Response
In this study, ex vivo quantitative and qualitative assessment of Ag.pTfh revealed key features of Ag.pTfh that favored vaccine responsiveness. In VRs, magnitude of response was impacted by both quality and quantity of Ag.pTfh cells, and these were compromised in old age in HCs and in young and old HIV+ individuals. In VNRs, in contrast, Ag.pTfh were heavily weighted towards an inflammatory phenotype irrespective of age or HIV status.
Our findings demonstrate that dysfunctional Ag.pTfh cells with an altered IL-21/IL-2 axis contribute to inadequate vaccine responses. Approaches for targeting inflammation or expanding...
Source: Fight Aging! - May 28, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Preserving Vaccines at Room Temperature Finally Possible
The availability of vaccines in poor and remote regions is usually the result of a lack of proper storage and transportation options. For most vaccines to survive, they must be kept cold and within a prescribed temperature range. Storage areas have t...
Source: Medgadget - May 23, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Public Health Source Type: blogs
Under the skin: listening to the voices of older people in influenza immunisation
This report finds that attitudes of older adults to influenza immunisation are a significant factor in influencing the vaccination rates amongst this group. It argues that efforts to increase the vaccination coverage rates among the older population needs to move beyond associating age with vulnerability and towards presenting immunisation as a positive and healthy lifestyle choice.Report
Source: Health Management Specialist Library - May 20, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Local authorities, public health and health inequalities Source Type: blogs
How Could Digital Tools Help Fight Against Anti-Vaccination?
Anti-vaccination movements lure increasingly more people into skipping potentially life-saving immunization against infectious diseases, such as measles, mumps, or rubella, highly impairing herd immunity for entire communities. Social media platforms could restrict the reach of anti-vax messages, groups, and activities, with algorithms recommending tailor-made content and health apps providing information about vaccinations. Here’s our collection of the most recent steps and digital tools supporting the fight against anti-vaccination and its believers.
300 percent increase in measles globally
In a widely shared soc...
Source: The Medical Futurist - May 8, 2019 Category: Information Technology Authors: nora Tags: Empowered Patients Future of Medicine anti-vaccination anti-vax anti-vaxxer digital disease disease outbreak facebook figth Health Healthcare infection Innovation measles movement social media technology Source Type: blogs
2019 Health Law Professors Conference
Conclusion
Source: blog.bioethics.net - March 27, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Beyond Vaccination: New Measures Needed to Protect Hospitals and the Public Against the Flu
By MARC M. BEUTTLER, MD
Every year at this time, you hear warnings that flu season has arrived. New data from the CDC indicates the season is far from over. So, you are urged by health authorities to get a flu shot. What you may not realize is how the flu can affect the hospitals you and your loved ones rely on for care.
In January, the large urban hospital where I am an intern faced the worst flu outbreak it has ever seen. Nearly 100 staff members tested positive for the flu. Residents assigned to back-up coverage were called to work daily to supplement the dwindling ranks of the sick. Every hospital vis...
Source: The Health Care Blog - March 22, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Hospitals Medical Practice Marc Beuttler Vaccination Source Type: blogs
Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Everyone Has a Part to Play in Ending Vaccine Hesitancy
Felicia D. Goodrum Sterling
Heidi L. Pottinger
By FELICIA D. GOODRUM STERLING, PhD and HEIDI L. POTTINGER, DrPH, MPH, MA
The measles outbreak in Washington state this week has brought new attention to the anti-vaccine movement. In fact, the World Health Organization recently identified “vaccine hesitancy” as one of top threats to global health. In the US, the number of unvaccinated children has quadrupled since 2001, enabling the resurgence of infectious diseases long-since controlled. In fact, the WHO claims a staggering 1.5 million deaths could be prevented worldwide by improved vaccination rates.
Amidst the medi...
Source: The Health Care Blog - February 12, 2019 Category: Consumer Health News Authors: matthew holt Tags: Patients Felicia Goodrum Sterling Global Health Heidi L. Pottinger public health The OpEd Project vaccines Source Type: blogs
4 things everyone needs to know about measles
We are in the midst of a measles outbreak here in the US, with cases being reported in New York City, New York state, and Washington state. In 2018, preliminary numbers indicate that there were 372 cases of measles — more than triple the 120 cases in all of 2017 — and already 79 cases in the first month of 2019 alone. Here are four things that everyone needs to know about measles.
Measles is highly contagious
This is a point that can’t be stressed enough. A full 90% of unvaccinated people exposed to the virus will catch it. And if you think that just staying away from sick people will do the trick, think again. Not o...
Source: Harvard Health Blog - February 5, 2019 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Infectious diseases Parenting Vaccines Source Type: blogs
Self-Administered Long-Lasting Contraceptive Patch
Long lasting female contraceptives typically require trained professionals to perform injections and to implant devices, something that’s not always available in low-resource settings. Researchers at Georgia Tech and University of Michi...
Source: Medgadget - January 28, 2019 Category: Medical Devices Authors: Editors Tags: Materials Ob/Gyn Reproductive Medicine Source Type: blogs
