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Asking the Wrong Questions about Aging and Disease
Age-related diseases began as a matter of taxonomy. Presented with the immensely complex, mysterious, varied, and inscrutable happenings at the end of life, the first scientists, before science was even much defined, began by trying to categorize their observations. Categorization is the first step towards making sense out of the unknown. Some forms of decline are obviously similar. Some are much worse than others in characteristic ways. Common manifestations are bucketed and given names: dementia, apoplexy, dropsy. These named facets of aging then became diseases just about as soon as people started to think that they cou...
Source: Fight Aging! - September 12, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 18th 2017
In this study, researchers put some numbers to the correlation, and improve on previous attempts to rule out wealth and other effects as significant contributing causes.
A study finds that a Chinese policy is unintentionally causing people in northern China to live 3.1 years less than people in the south, due to air pollution concentrations that are 46 percent higher. These findings imply that every additional 10 micrograms per cubic meter of particulate matter pollution reduces life expectancy by 0.6 years. The elevated mortality is entirely due to an increase in cardiorespiratory deaths, indicating that air poll...
Source: Fight Aging! - September 17, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Inevitability of the Transhumanist Vision
The article I'll point out today opens by distinguishing capitalized Transhumanism from lower case transhumanism. These are visions of the future grown in that fertile square of ground whose corners are marked by contemporary science fiction, the cutting edge of engineering, the cutting edge of science, and the entrepreneurial community. The real entrepreneurial community, I mean, the people who quietly get things done, not the loud internet-focused groups that you tend to read about in the media. Transhumanism with a small t is a simple description of what we will achieve with technology: we will transform ourselves and s...
Source: Fight Aging! - September 14, 2016 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, September 19th 2016
In conclusion, we found that IS status was associated with a significant increase in Hannum DNA methylation, likely as a consequence of the accumulation of cardiovascular risk factors, and near signification with Horvath method. Patients with IS were biologically older than controls, a difference that was more obvious in young stroke. This could open up the possibility of useful new biomarker of stroke risk.
Latest Headlines from Fight Aging!
A Profile of Kelsey Moody and Ichor Therapeutics
https://www.fightaging.org/archives/2016/09/a-profile-of-kelsey-moody
Source: Fight Aging! - September 18, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Measuring Gene Expression Changes in the Brain as a Result of Heart Failure
Heart failure causes harm to the brain by reducing the supply of blood, and thus the supply vital nutrients and oxygen, to brain cells. The precise details of how this leads to cognitive decline are yet to be fully mapped. Researchers here assess changes in gene expression the brains of mice suffering from heart failure, as a starting point for further investigation of specific mechanisms. The best path forward for this class of contribution to neurodegenerative conditions is to prevent or reverse vascular aging, which has numerous components. There is the narrowing of blood vessels via atherosclerosis; the failure of smoo...
Source: Fight Aging! - April 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders.
Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Eric Verdin of the Buck Institute for Research on Aging
Eric Verdin is the present CEO of the Buck Institute for Research on Aging. From my perspective most of the research programs carried out there, with the notable exception of matters involving cellular senescence, is fairly distant from the SENS rejuvenation research we'd like to see prosper. The Buck Institute as a whole reflects the broader research community focus on greater understanding of how aging progresses at the detail level, absent intervention, and on the development of ways to modestly slow the accumulation of damage, such as calorie restriction mimetic drugs.
Thus even among those researchers intereste...
Source: Fight Aging! - July 3, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 10th 2017
This article covers some of the advances of recent years in understanding the effects of varied forms of calorie restriction in humans. Efforts to quantify the results and find a good 80/20 point, at which most of the effects of longer and more stringent reductions in calorie intake are still evident, have resulted in practical outcomes. A number of quite interesting discoveries have been made along the way, such as the ability of longer fasting periods to clear out and replace damaged immune cells to some degree.
The second phase of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (C...
Source: Fight Aging! - July 9, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ADAM17 and Caveolin-1 in Cardiac Syndrome X
Cardiac syndrome X has the standard risk factors for cardiovascular disease, which is to say age of the individual and degree of excess fat tissue carried by the individual. It is a comparatively poorly understood variety of structural alteration and failure of blood vessels, however. The risk factors are well known, but the biochemistry is yet to be mapped in full. Here, researchers shed more light onto what is taking place under the hood.
"Older obese patients and sometimes women who suffer heart failure go to the cardiac catheterization lab and the cardiologist finds nothing that would explain their heart failu...
Source: Fight Aging! - July 14, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Computational Geneticist Discusses Genetics of Storytelling at Sundance Film Festival
About 10 years ago, University of Utah geneticist Mark Yandell developed a software platform called VAAST (Variant Annotation, Analysis & Search Tool) to identify rare genes. VAAST, which was funded by NHGRI, was instrumental in pinpointing the genetic cause of a mystery disease that killed four boys across two generations in an Ogden, UT family.
NIGMS has been supporting Yandell’s creation of the next generation of his software, called VAAST 2, for the past few years. The new version incorporates models of how genetic sequences are conserved among different species to improve accuracy with which benign genetic seque...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 1, 2018 Category: Research Authors: Chris Palmer Tags: Computers in Biology Genetics Source Type: blogs
Can Too Much Exercise Reduce Longevity?
There are many animal studies showing that moderate exercise causes extended health and many human epidemiological studies showing a robust correlation between moderate exercise, better health, and extended life expectancy. This should give us confidence in believing that yes, being sedentary is bad for us and the practice of at least moderate exercise is good for us. Showing causation in human studies is a real challenge, however, which is why there is still uncertainty over whether a lot of exercise is better, worse, or no different for longevity than the moderate 30 minutes a day recommended by most physicians. We can p...
Source: Fight Aging! - July 16, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Trials of Cell Therapies for Heart Regeneration
Stem cell therapies to repair heart damage were one of the first to become widely available via medical tourism, and have been underway in earnest for more than a decade now. There is evidence from their use that benefits can be attained for patients. Providers and researchers continue to refine their techniques. There are numerous studies. That evidence is not good enough for the conservative end of the scientific community, who require a complete and rigorous understanding of the mechanisms of action before proceeding with enthusiasm, and nor for regulatory bodies in the US and Europe. Thus trials continue, now into thei...
Source: Fight Aging! - May 22, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Healing Damaged Hearts With Stem Cell Implants Gets New Technique
We’re much better at saving the lives of those who suffer a heart attack these days. Sadly, many people survive a heart attack only to later succumb to heart failure from the damage it caused. Modern methods help heal the heart somewhat after a heart attack, but cardiologists think stem cell therapy might one day […]
Source: Biosingularity - November 4, 2013 Category: Research Authors: Derya Tags: Biotechnology Source Type: blogs
Lack of Exercise and Excess Weight Increases Risk of Untreatable Heart Failure
If you were in search of yet more reasons to keep up with the health basics, meaning regular exercise, a sensible diet, and avoidance of weight gain, then look no further. Here, researchers note that a sedentary lifestyle and excess weight in the form of visceral fat tissue significantly increase the odds of suffering a class of heart failure that currently lacks any good form of treatment.
Heart failure is a chronic condition in which the heart is unable to supply enough oxygenated blood to meet the demands of the body. Heart failure is approximately equally divided between two subtypes: heart failure with preser...
Source: Fight Aging! - March 1, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Using Photosynthetic Microbes to Oxygenate Ischemic Tissue
Ischemic injuries, in which insufficient oxygen is delivered to tissues, can occur in numerous ways, but heart attacks are among the most common, evident, and dangerous. A sizable branch of the research community works on ways to efficiently and quickly provide oxygen to the impacted tissues so as to reduce the long-term damage and speed recovery. At the end of this road lie permanent enhancements such as respirocyte nanomachinery that will provide hours of supplemental oxygen for all tissues, but for now researchers are still working on the first potential advances in emergency oxygen supplementation, such as the example ...
Source: Fight Aging! - June 15, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
