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Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 6, 2022 Category: Surgery Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research

Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association.
gy; and Council on Cardiovascular and Stroke Nursing Abstract Cardio-oncology has organically developed as a new discipline within cardiovascular medicine as a result of the cardiac and vascular adverse sequelae of the major advances in cancer treatment. Patients with cancer and cancer survivors are at increased risk of vascular disease for a number of reasons. First, many new cancer therapies, including several targeted therapies, are associated with vascular and metabolic complications. Second, cancer itself serves as a risk factor for vascular disease, especially by increasing the risk for thromboembolic events...
Source: Circulation - February 21, 2019 Category: Cardiology Authors: Campia U, Moslehi JJ, Amiri-Kordestani L, Barac A, Beckman JA, Chism DD, Cohen P, Groarke JD, Herrmann J, Reilly CM, Weintraub NL, American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biol Tags: Circulation Source Type: research

Vildagliptin improves vascular smooth muscle relaxation and decreases cellular senescence in the aorta of doxorubicin-treated rats
CONCLUSION: In summary we conclude that vildagliptin can reduce senescence and improve relaxation of vascular smooth muscle in the aorta of DOX-treated rats, and GLP-1 can reduce senescence of DOX-treated VSMCs. These data suggest that incretin-based drugs are promising candidates for patients suffering from late doxorubicin cardiovascular toxicity.PMID:33744414 | DOI:10.1016/j.vph.2021.106855
Source: Vascular Pharmacology - March 21, 2021 Category: Drugs & Pharmacology Authors: Svetoz ár Mišúth Mar ína Uhrinová J án Klimas Diana Vavrincov á-Yaghi Peter Vavrinec Source Type: research

In-hospital and postdischarge venous thromboembolism after vascular surgery
This study used a national, prospective, multicenter database to define the incidence of overall and postdischarge VTE after major vascular operations and assess risk factors associated with VTE development.Methods: Patients with VTE who underwent elective vascular procedures (n = 45,548) were identified from the 2007-2009 National Surgical Quality Improvement Program (NSQIP) database. The vascular procedures included carotid endarterectomy (CEA; n = 20,785), open thoracoabdominal aortic aneurysm (TAAA) repair (n = 361), thoracic endovascular aortic repair (TEVAR; n = 732), open abdominal aortic (OAA) surgery (n = 619...
Source: Journal of Vascular Surgery - February 8, 2013 Category: Surgery Authors: Bala Ramanan, Prateek K. Gupta, Abhishek Sundaram, Thomas G. Lynch, Jason N. MacTaggart, B. Timothy Baxter, Jason M. Johanning, Iraklis I. Pipinos Tags: Clinical research studies Source Type: research

New insights in the control of vascular permeability: vascular endothelial-cadherin and other players
Purpose of review: The control of the endothelial barrier function is essential for vascular homeostasis and is mainly mediated by cell-to-cell junctions that tightly regulate permeability to plasma solutes and circulating cells such as leukocytes and tumor cells. While in some circumstances the transient dismantling of endothelial cell junctions might be beneficial, in pathological conditions, such as cancer, severe alterations of endothelial junction composition and function are detrimental, causing massive edema and increased interstitial pressure. Here, we aim to discuss the newly and most recently identified molecular...
Source: Current Opinion in Hematology - April 10, 2015 Category: Hematology Tags: VASCULAR BIOLOGY: Edited by Thomas F. Deuel Source Type: research

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis
Conclusion These findings indicate that the AM-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability and EndMT-like change within primary lesions and formation of pre-metastatic niches in distant organs by destabilizing the vascular structure and inducing inflammation. Vascular integrity regulated by the AM-RAMP2 system could thus be a hopeful therapeutic target for suppressing tumour metastasis.
Source: Cardiovascular Research - August 23, 2016 Category: Cardiology Authors: Tanaka, M., Koyama, T., Sakurai, T., Kamiyoshi, A., Ichikawa-Shindo, Y., Kawate, H., Liu, T., Xian, X., Imai, A., Zhai, L., Hirabayashi, K., Owa, S., Yamauchi, A., Igarashi, K., Taniguchi, S., Shindo, T. Tags: Vascular Biology Source Type: research

Inhibition of Vascular Calcification.
Conclusions- Our study demonstrates that teniposide reduces vascular calcification by regulating p53-(miR-203-3p)-BMP2 signaling pathway, which contributes to the antiatherogenic properties of Topo II inhibitors. PMID: 30354214 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 1, 2018 Category: Cardiology Authors: Liu L, Zeng P, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J, Chen Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

PICC-PORT totally implantable vascular access device in breast cancer patients undergoing chemotherapy.
CONCLUSION: The peripherally inserted central catheter-PORT is a safe vascular device for chemotherapy delivery that achieves similar clinical results as traditional long-term vascular access devices (peripherally inserted central catheter and arm totally implantable vascular access device, in particular) in breast cancer patients. PMID: 31674857 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - November 2, 2019 Category: Surgery Tags: J Vasc Access Source Type: research

Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis
The molecular signaling cascades that regulate angiogenesis and microvascular remodeling are fundamental to normal development, healthy physiology, and pathologies such as inflammation and cancer. Yet quantifying such complex, fractally branching vascular patterns remains difficult. We review application of NASA ’s globally available, freely downloadable VESsel GENeration (VESGEN) Analysis software to numerous examples of 2D vascular trees, networks, and tree-network composites. Upon input of a binary vascular image, automated output includes informative vascular maps and quantification of parameters suc h as tortuosity,...
Source: Journal of Vascular Research - April 9, 2021 Category: Research Source Type: research

Antineoplastic drugs inducing cardiac and vascular toxicity - An update
Vascul Pharmacol. 2023 Sep 5:107223. doi: 10.1016/j.vph.2023.107223. Online ahead of print.ABSTRACTWith the improvement in cancer prognosis due to advances in antitumor therapeutic protocols and new targeted and immunotherapies, we are witnessing a growing increase in survival, however, at the same timeincrease in morbidity among cancer survivors as a consequences of the increased cardiovascular adverse effects of antineoplastic drugs. Common cardiovascular complications of antineoplastic therapies may include cardiac complications such as arrhythmias, myocardial ischemia, left ventricular dysfunction culminating in heart ...
Source: Vascular Pharmacology - September 7, 2023 Category: Drugs & Pharmacology Authors: Serena Barachini Sandra Ghelardoni Zolt án V Varga Radwa A Mehanna Maria Magdalena Montt-Guevara P éter Ferdinandy Rosalinda Madonna Source Type: research