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Total 97554 results found since Jan 2013.

Neuro-Ophthalmic Manifestations of Intracranial Malignancies
Conclusion: Intracranial malignancies can present with neuro-ophthalmic symptoms or signs depending on topographical localization. Specific neuro-ophthalmic presentations are associated with different malignant intracranial tumors. Clinicians should be aware of the common malignant intracranial tumors and their associated clinical presentations in neuro-ophthalmology.
Source: Journal of Neuro-Ophthalmology - August 25, 2020 Category: Opthalmology Tags: Trainees' Corner Source Type: research

Neuro-Ophthalmic Complications in Patients Treated With CTLA-4 and PD-1/PD-L1 Checkpoint Blockade
Conclusion: This study describes the variable neuro-ophthalmic adverse events associated with use of immune checkpoint inhibitors and contributes a more thorough understanding of their clinical presentations and treatment outcomes. We expect this will increase awareness of these drug complications and guide specialists in the care of these patients.
Source: Journal of Neuro-Ophthalmology - November 22, 2021 Category: Opthalmology Tags: Original Contribution Source Type: research

Management of squamous cell carcinomas of the skull-base
ConclusionSquamous cell carcinoma (SCC) is the most common cancer occurring in the Head and Neck. Squamous cell carcinoma is also the most common cancer arising within the nose and sinuses of which skull-base squamous cell carcinoma is a rare subgroup.Evidence relating to the management and survival of skull-base SCC is based on expert opinion and. retrospective analyses Clinical examination and biopsy, imaging and a broad multidisciplinary team are key to the management of skull-base SCC. The information gathered should be used to guide informed discussion by suitably trained experts with patients regarding surgical appro...
Source: Journal of Neuro-Oncology - June 4, 2020 Category: Cancer & Oncology Source Type: research

P13.05 Success Rate and Early Morbidity from Image-Guided Ommaya Reservoir Placement for Intraventricular Chemotherapy: Case Series and Systematic Review
Conclusions:Our findings suggest improved accuracy and decreased complications using an image-guided approach compared with a traditional approach. Our results support routine use of intra-operative image guidance for proximal catheter insertion in elective Ommaya reservoir placement for intraventricular chemotherapy.
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Lau, J. C., Macdonald, D. R., Megyesi, J. F. Tags: P13 Brain and leptomeningeal metastases Source Type: research

Cognitive Impairment Associated with Cancer: A Brief Review
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research

Unusual Presentation Of An Isolated III Cranial Nerve Palsy From Brain Metastasis (P2.297)
CONCLUSIONS:This case shows the possibility of an isolated 3rd cranial nerve palsy as a unique and exclusive manifestation of a brain metastasis. A thorough neuro-ophthalmologic examination is crucial in early detection of this life-threatening condition.Study Supported by: N/ADisclosure: Dr. Choudhry has nothing to disclose. Dr. Valenzuela has nothing to disclose. Dr. Nersesyan has nothing to disclose. Dr. Kattah has received personal compensation for activities with Pfizer, Inc. as a consultant.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Choudhry, S., Valenzuela, R., Nersesyan, H., Kattah, J. Tags: Neuro-ophthalmology/Neuro-otology I Source Type: research

Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma
Abstract Choroid plexus carcinoma (CPCs) is a rare, malignant, primary brain tumor with a poor prognosis. Currently, there is no consensus on the use of adjuvant therapy, and few large-scale studies focus exclusively on the pediatric population. We performed a comprehensive systematic review of pediatric CPCs to determine the effects of various adjuvant therapy modalities on overall survival (OS). A literature search was performed to identify studies reporting children with CPC who underwent surgical resection. Only patients who had clearly received adjuvant therapy, or were described as not selected for adjuvant...
Source: Journal of Neuro-Oncology - October 23, 2014 Category: Cancer & Oncology Source Type: research

Intramedullary Metastasis From Ovarian Cancer: A Systematic Review of the Literature (P3.137)
Conclusion: intramedullary metastasis from ovarian tumor accounts for 1-2.2[percnt] of all intramedullary metastasis. The tumor types reported included serous adenocarcinoma and poorly differentiated carcinoma-not otherwise specified. Survival beyond two years have been reported with combination of resection and radiotherapy.Disclosure: Dr. Safarpour has nothing to disclose. Dr. Tavassoli has nothing to disclose. Dr. Jabbari has received research support from Allergan Inc., Merz Pharma, and Ipsen.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Safarpour, D., Tavassoli, F., Jabbari, B. Tags: Neuro-oncology: CNS Metastases and Other Neurologic Complications of Cancer Source Type: research

Incidence and spectrum of paraneoplastic neurological syndromes: single center study
In this study conducted from a super speciality teaching institute from South India, forty five (incidence-0.25 %) patients were diagnosed with PNS based on the clinical data. They were subdivided into two groups patients with central nervous system (CNS) manifestations and those with neuromuscular manifestations. Immunological markers were assessed in a subset of patients. Majority of them (75.6 %) were above 40 years. There was no sex predilection and a chronic presentation was common (42.2 %). While more than half had involvement of peripheral nervous system (64.4 %), CNS manifestations were present in 16 (35.6 %)...
Source: Journal of Neuro-Oncology - August 27, 2015 Category: Cancer & Oncology Source Type: research

P14.05 Bilateral hypoglossal palsy after radiation therapy for nasopharyngeal carcinoma: a case report
A 63-year-old lady was adimtted to the EU of Lecco hospital with a clinical history of neck pain in the last 2 months and difficulty in swallowing and chewing and in speech in the last few days.Neurological examination disclosed bilateral deficit in tongue protrusion, more on the left side, with slight amyotrophy of the left side of the tongue.Her remote history included tonsillectomy and - 6 years before - biopsy of a neck lymphnode on the left (histological diagnosis of undifferentiated carcinoma) in the context of a left rhinopharyngeal mass subsequently operated and diagnosed as a lymphoepithelial rinoph...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Silvani, A., Salmaggi, A., Rigamonti, A., Stanzani, L., Mantero, V., Rossi, G. Tags: P14 Neurotoxicity and neuroprotection Source Type: research

Pancreatic Cancer with Leptomeningeal Carcinomatosis: Case Presentation and Literature Review (P5.181)
Conclusions:Pancreatic cancer associated LMC is extremely rare. With increased systemic control, however, there may be increasing occurrence of LMC and/or parenchymal involvement. To date, as with LMC associated with other solid tumors, survival is poor.Study Supported by: Not applicableDisclosure: Dr. Perilla has nothing to disclose. Dr. Melian has nothing to disclose. Dr. Schneck has received research support from NIH (POINT, COSS, ARUBA, ALIAS, Lundbeck (DIAS4), TIMI-50 Consortium, and Local PI Multicenter Clincial trials
Source: Neurology - April 17, 2017 Category: Neurology Authors: Perilla, A. S., Melian, E., Schneck, M. Tags: Neuro-oncology: Brain and CNS Metastases Source Type: research

Gene signature associated with neuro ‐endocrine activity predicting prognosis of pancreatic carcinoma
ConclusionA specific four genes signature with the ability to predicted survival of pancreatic carcinoma was generated, which may indicate the connection between neuro ‐endocrine activity and patients’ prognosis.
Source: Molecular Genetics & Genomic Medicine - May 16, 2019 Category: Genetics & Stem Cells Authors: Ke Chen, Yiping He, Yuan Liu, Xiujiang Yang Tags: ORIGINAL ARTICLE Source Type: research

Cylindroma spine metastasis: long-term follow-up is required.
Conclusion This case highlights the critical importance of long follow up of ACC patients, due to late spine metastases. Diagnosis spinal metastasis of salivary carcinoma should be considered, to guide management, especially in clinical follow-up. PMID: 31634508 [PubMed - as supplied by publisher]
Source: Neuro-Chirurgie - October 17, 2019 Category: Neurosurgery Authors: Riche M, Mathon B, Mokhtari K, Carpentier A, Amelot A Tags: Neurochirurgie Source Type: research

A review of glioblastoma immunotherapy
ConclusionsCurrent clinical trials are exploring combination therapy and novel treatment strategies beyond immune checkpoint therapies and vaccine therapy such as CAR T cells. There is also an effort to establish synergy between immunotherapy and current standard of care. Furthermore, recent advances in personalized neoantigen vaccines suggest a shift towards personalized, patient-specific GBM treatment.
Source: Journal of Neuro-Oncology - April 5, 2020 Category: Cancer & Oncology Source Type: research

Radiation therapy-induced neuro-Sweet disease in a patient with oral squamous cell carcinoma.
We present a novel case of radiation therapy-induced neuro-Sweet disease in a patient receiving treatment for an oral squamous cell carcinoma. PMID: 26821310 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - January 28, 2016 Category: Dermatology Authors: Wallett A, Newland K, Foster-Smith E Tags: Australas J Dermatol Source Type: research