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Cistanche tubulosa phenylethanoid glycosides induce apoptosis in H22 hepatocellular carcinoma cells through both extrinsic and intrinsic signaling pathways
Cistanche tubulosa (Schenk) R. Wight is a traditional Chinese medicine that parasitizes the roots of the Tamarix plant and has been used to treat male impotence, sterility, body weakness, and as a tonic. However,...
Source: BMC Complementary and Alternative Medicine - October 12, 2018 Category: Complementary Medicine Authors: Pengfei Yuan, Jinyu Li, Adila Aipire, Yi Yang, Lijie Xia, Xinhui Wang, Yijie Li and Jinyao Li Tags: Research article Source Type: research
The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: a case series
The purpose of this study was to evaluate the benefit of induction chemotherapy followed by surgery in locally advanced unresectable stage IVb laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).
Source: Journal of Otolaryngology - Head and Neck Surgery - October 16, 2018 Category: ENT & OMF Authors: Pichit Sittitrai, Donyarat Reunmarkkaew and Saisaward Chaiyasate Tags: Original research article Source Type: research
MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis
There is increasing evidence that liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a significant functional role by directly regul...
Source: Journal of Experimental and Clinical Cancer Research - October 16, 2018 Category: Cancer & Oncology Authors: Yu-Shui Ma, Zhong-Wei Lv, Fei Yu, Zheng-Yan Chang, Xian-Ling Cong, Xiao-Ming Zhong, Gai-Xia Lu, Jian Zhu and Da Fu Tags: Research Source Type: research
ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a high incidence and high mortality in East Asia. Identifying biomarkers and clarifying the regulatory mechanisms of HCC are of g...
Source: Journal of Experimental and Clinical Cancer Research - October 30, 2018 Category: Cancer & Oncology Authors: Cong Chen, Chao Ge, Zheng Liu, Liangyu Li, Fangyu Zhao, Hua Tian, Taoyang Chen, Hong Li, Ming Yao and Jinjun Li Tags: Research Source Type: research
SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells
Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently ov...
Source: Cell Communication and Signaling - November 7, 2018 Category: Molecular Biology Authors: Ana Sofia Ribeiro, Ana Rita Nobre, Nuno Mendes, Jo ão Almeida, André Filipe Vieira, Bárbara Sousa, Filomena A. Carvalho, Joana Monteiro, António Polónia, Martina Fonseca, João Miguel Sanches, Nuno C. Santos, Raquel Seruca and Joana Paredes Tags: Research Source Type: research
Secretory carcinoma: the eastern Canadian experience and literature review
This study aimed ...
Source: Journal of Otolaryngology - Head and Neck Surgery - November 16, 2018 Category: ENT & OMF Authors: David Forner, Martin Bullock, Daniel Manders, Timothy Wallace, Christopher J. Chin, Liane B. Johnson, Matthew H. Rigby, Jonathan R. Trites, Mark S. Taylor and Robert D. Hart Tags: Original research article Source Type: research
Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study
We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC).
Source: Journal of Otolaryngology - Head and Neck Surgery - December 4, 2018 Category: ENT & OMF Authors: Alexandra E. Quimby, Nicole L. Lebo, Rebecca Griffiths, Stephen Hall, Jim Dimitroulakos and Stephanie Johnson-Obaseki Tags: Original research article Source Type: research
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in many cancers, including oral squamous cell carcinoma (OSCC). However, the serum APE1/REF-1 level remains unknown in such patients. The purpose of the present study was to estimate the serum APE/Ref-1 levels in patients with OSCC and measure its association with the diagnosis, clinicopathologic features, and prognosis of OSCC.
Source: Journal of Oral and Maxillofacial Surgery - December 11, 2018 Category: ENT & OMF Authors: Jianli Xie, Ying Li, Jingjing Kong, Chong Li Tags: Surgical oncology and reconstruction Source Type: research
Isolated gluteal metastasis 3 years after sufficiently treated oral squamous cell carcinoma: Case report and literature review
Metastases from oral squamous cell carcinoma usually occur in the cervical lymph nodes. Distant skeletal muscle metastases are exceedingly rare and have been reported only in sporadic cases. A 70-year-old male patient was diagnosed with nonmetastatic oral squamous cell carcinoma (pT4a, N0, M0). The patient underwent successful surgical treatment involving tumor resection and selective neck dissection of both sides, including adjuvant radiotherapy. After 3 years of uneventful course, with no clinical or radiographic evidence for local recurrence or metastasis, an isolated distant metastasis in the gluteal muscles was diagnosed.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2018 Category: ENT & OMF Authors: Andreas Naros, Hannes Weise, Michael Krimmel, Siegmar Reinert Tags: Oral and Maxillofacial Surgery Source Type: research
Effect of hepatitis B virus DNA replication level and anti-HBV therapy on microvascular invasion of hepatocellular carcinoma
Chronic hepatitis B virus (HBV) infection is a major risk factor for the occurrence and development of cirrhosis and hepatocellular carcinoma (HCC). Microvascular invasion (MVI) of HCC is closely related to po...
Source: Infectious Agents and Cancer - January 21, 2019 Category: Cancer & Oncology Authors: Chao Qu, Xinyu Huang, Kui Liu, Kun Li, Bin Tan, Linlin Qu, Jingyu Cao and Chengzhan Zhu Tags: Research article Source Type: research
Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/ β-catenin signaling
The primary obstacle to treat cervical cancer is its high prevalence of metastasis, which severely affects patients ’ quality of life and survival time. Nucleolar and spindle associated protein 1 (NUSAP1) has b...
Source: Journal of Experimental and Clinical Cancer Research - January 24, 2019 Category: Cancer & Oncology Authors: Han Li, Weijing Zhang, Ming Yan, Jiaqi Qiu, Jueming Chen, Xiaoying Sun, Xiangfu Chen, Libing Song and Yanna Zhang Tags: Research Source Type: research
Albumin-Bilirubin (ALBI) as an accurate and simple prognostic score for chronic hepatitis B-related liver cirrhosis
The Albumin –Bilirubin (ALBI) score was developed to predict the long-term prognosis of hepatocellular carcinoma patients. We aimed to investigate the performance of ALBI for predicting severity and long-term prognosis of chronic hepatitis B-related liver cirrhosis (CHB-LC).
Source: Digestive and Liver Disease - January 25, 2019 Category: Gastroenterology Authors: Jian Wang, Zhaoping Zhang, Xiaomin Yan, Ming Li, Juan Xia, Yong Liu, Yuxin Chen, Bei Jia, Li Zhu, Chuanwu Zhu, Rui Huang, Chao Wu Tags: Liver, Pancreas and Biliary Tract Source Type: research
H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma
Over-expression and over-activation of immunosuppressive enzyme indoleamine 2, 3 -dioxygenase 1 (IDO1) is a key mechanism of cancer immune escape. However, the regulation of IDO1 has not been fully studied. Th...
Source: Journal of Experimental and Clinical Cancer Research - February 18, 2019 Category: Cancer & Oncology Authors: Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang and Qing Yang Tags: Research Source Type: research
Conservative treatment of early-stage endometrial carcinoma in patients wishing fertility preservation using the example of the Department of Obstetrics and Gynecology at the University of Tuebingen
Introduction: The endometrial carcinoma is the most common gynecologic malignancy in developed countries. Although it mostly affects postmenopausal women, today more and more patients are found to be premenopausal because of an increasing number of women who wish to be pregnant later in life on one hand and the problem of increasing obesity on the other hand.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 19, 2019 Category: OBGYN Authors: Juergen Andress, Jana Pasternak, Florin-Andrei Taran, Andreas Hartkopf, Stefan Kommoss, Sara Brucker Tags: Session 34 – Oncology and fertility preservation Source Type: research
Does adenocarcinoma and squamous cell carcinoma subtypes effect survival in locally advanced cervical cancer?
Introduction: Although the incidence of cervical carcinoma decreased, the incidence of cervical adenocarcinoma (AC) was reported to increase compared to squamous cell carcinoma (SCC) Histology of adenocarcinoma was reported to have poor prognostic both in early and advanced cervical cancer in some reports.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 19, 2019 Category: OBGYN Authors: Selcuk Erkilinc Tags: Session 34 – Oncology and fertility preservation Source Type: research
