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Total 31038 results found since Jan 2013.
Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo
Conclusion Our studies suggest that the use of TCM cytotoxic genes is a useful therapeutic strategy for treating human cancers in general, and liver tumors in particular.
Source: Journal of Integrative Medicine - November 28, 2014 Category: Complementary Medicine Source Type: research
Safety aspects of Chinese herbal medicine in pregnancy-Re-evaluation of experimental data of two animal studies and the clinical experience.
CONCLUSION: WS and LS are not reliable data sources for deriving pregnancy risks in humans for the tested Chinese medicinals. In addition, the results appear to contradict the outcomes observed in the treatment of humans. Regarding teratogenicity, for most Chinese medicinals, neither the safety nor the risk during pregnancy can be definitively ascertained. Further studies on the risks of Chinese medicinals during pregnancy are urgently needed.
PMID: 25440387 [PubMed - as supplied by publisher]
Source: Complementary Therapies in Medicine - October 1, 2014 Category: Complementary Medicine Authors: Wiebrecht A, Gaus W, Becker S, Hummelsberger J, Kuhlmann K Tags: Complement Ther Med Source Type: research
Chinese medicine herbal treatment based on syndrome differentiation improves the overall survival of patients with unresectable hepatocellular carcinoma
Conclusions
CM herbs based on syndrome differentiation have positive effects on survival of patients with unresectable HCC. Furthermore, combination therapy of CM and WM are recommended in HCC treatment.
Source: Chinese Journal of Integrative Medicine - December 23, 2014 Category: Internal Medicine Source Type: research
PD-L1 and Lung Cancer: The Era of Precision-ish Medicine?
Abstract
The success of immune checkpoint inhibitor therapy in lung cancer, both in squamous and nonsquamous non-small cell carcinoma, has led to US Food and Drug Administration approval for 2 medications that have as part of their prescribing information an associated immunohistochemistry-based companion or complementary diagnostic test for programmed death ligand 1 (PD-L1). The intense interest in drug development in this area has resulted in additional agents with associated diagnostics looming on the horizon in 2016. In the era of precision medicine, the paradigm of paired molecular target and molecular test, ...
Source: Archives of Pathology and Laboratory Medicine - January 12, 2016 Category: Laboratory Medicine Authors: Borczuk AC, Allen TC Tags: Arch Pathol Lab Med Source Type: research
Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity.
Authors: Lu J, Zhang X, Shen T, Ma C, Wu J, Kong H, Tian J, Shao Z, Zhao X, Xu L
Abstract
Traditional Chinese medicine Jinfukang (JFK) has been clinically used for treating lung cancer. To examine whether epigenetic modifications are involved in its anticancer activity, we performed a global profiling analysis of H3K4Me3, an epigenomic marker associated with active gene expression, in JFK-treated lung cancer cells. We identified 11,670 genes with significantly altered status of H3K4Me3 modification following JFK treatment (P < 0.05). Gene Ontology analysis indicates that these genes are involved in tumor-related...
Source: Evidence-based Complementary and Alternative Medicine - April 20, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study
Conclusions
The use of CHM was associated with a significantly reduced HCC risk in patients with CHB, which supports the integration of TCM with CHM into clinical practice to influence a favourable prognosis.
Source: BMJ Open - January 24, 2017 Category: Journals (General) Authors: Tsai, T.-Y., Livneh, H., Hung, T.-H., Lin, I. -H., Lu, M.-C., Yeh, C.-C. Tags: Open access, Complementary medicine, Gastroenterology and hepatology Research Source Type: research
Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor- β1 signaling pathway
Conclusion YKF can inhibit tumor growth synergistically with DDP, mainly through the TGF-β1 signaling pathway.
Source: Journal of Integrative Medicine - May 24, 2017 Category: Complementary Medicine Source Type: research
Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSION: Add-on therapy with TCM could improve overall survival, increase clinical tumor responses, lead to better QOL, and reduce adverse events in hepatocellular carcinoma.
PMID: 28680448 [PubMed - in process]
Source: Evidence-based Complementary and Alternative Medicine - July 7, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways.
In conclusion, JR inhibits liver cancer cells migration and invasion through epithelial mesenchymal transition (EMT) inhibition via Smad2/3 dependent and independent pathways, suggesting it is an effective therapeutic strategy against HCC metastasis.
PMID: 30174709 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Chinese Herbal Medicine (Chaihu-Huaji Decoction) Alleviates Postembolization Syndrome following Transcatheter Arterial Chemoembolization and Improves Survival in Unresectable Hepatocellular Cancer: A Retrospective Study.
Conclusion: Chaihu-huaji decoction may prevent adverse events after TACE and prolong overall survival of unresectable HCC patients when combined with TACE.
PMID: 30854013 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - March 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Using Traditional Chinese Medicine to Treat Hepatocellular Carcinoma by Targeting Tumor Immunity.
Authors: Jia W, Wang L
Abstract
As the leading cause of cancer-related death, hepatocellular carcinoma (HCC) threatens human health and limited treatments are available to cure the disease efficiently and effectively. The particularly immunotolerant environment of the liver lowers the efficacy of current therapies in patients with advanced HCC. Traditional Chinese medicine (TCM) is gathering increasing interest due to the immunoregulatory properties of certain compounds. In advanced HCC, TCM can restore immunosurveillance to promote antitumor effects in several ways, including the upregulation of immunostimulatory ...
Source: Evidence-based Complementary and Alternative Medicine - July 2, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Traditional Chinese medicine for oral squamous cell carcinoma: A Bayesian network meta-analysis protocol
Conclusions:
The findings will provide reference for evaluating the efficacy and safety of different traditional Chinese medicine for OSCC, and provide a helpful evidence for clinicians to formulate the best adjuvant treatment strategy for OSCC patients.
Trial registration number:
INPLASY202090082.
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Genome editing with CRISPR-Cas9: A budding biological contrivance for colorectal carcinoma research and its perspective in molecular medicine.
Abstract
Genome editing is an addition, deletion, or replacement of a gene for wiping out or initiating explicit and preferred characters in the genome. Utilizing gene editing tools like CRISPR-Cas9 technology could be accomplished either by gene-based methodology or protein based technology that has been under scrutiny for protracted time wherein physical techniques, viral and non-viral strategies have been utilized together. Transplanting ex vivo CRISPR edited cells empowers screening of single guide RNAs with high-throughput and CRISPR based screening in organoids transplantation to validate cancer cells includ...
Source: Current Molecular Medicine - November 19, 2020 Category: Molecular Biology Authors: Ray SK, Mukherjee S Tags: Curr Mol Med Source Type: research
Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology
CONCLUSION: We propose a new research method of "prognosis of TCM syndromes-KCMMs-network pharmacology" to reveal the prognostic value of TCM syndromes and the potential mechanism by which TCM syndromes affect prognosis.PMID:34306165 | PMC:PMC8263254 | DOI:10.1155/2021/9991533
Source: Evidence-based Complementary and Alternative Medicine - July 26, 2021 Category: Complementary Medicine Authors: Zhulin Wu Chunshan Wei Lianan Wang Li He Source Type: research
