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Cancer: Carcinoma
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Total 106673 results found since Jan 2013.
NCAPG is a prognostic biomarker associated with vascular invasion in hepatocellular carcinoma
CONCLUSIONS: NCAPG upregulation is associated with poor prognosis in hepatocellular carcinoma patients with vascular invasion.PMID:34919223 | DOI:10.26355/eurrev_202112_27417
Source: European Review for Medical and Pharmacological Sciences - December 17, 2021 Category: Drugs & Pharmacology Authors: Z-Y Guo Z-T Zhu Source Type: research
Extramural vascular invasion as an independent prognostic marker in locally advanced rectal cancer: propensity score match pair analysis
CONCLUSION: Extramural vascular invasion detected through MRI is an independent risk factor for distant metastasis in the locally advanced carcinoma rectum. Aggressive treatment regimens like total neoadjuvant treatment should be considered in these cases pending randomized control studies.PMID:36085377 | DOI:10.1007/s00261-022-03608-z
Source: Cancer Control - September 10, 2022 Category: Cancer & Oncology Authors: Sonz Paul Supreeta Arya Smruti Mokul Akshay Baheti Suman Kumar Anant Ramaswamy Vikas Ostwal Supriya Chopra Avanish Saklani Ashwin deSouza Mufaddal Kazi Reena Engineer Source Type: research
Vascular Invasion Predicts Recurrence in Stage IA2-IB Lung Adenocarcinoma but not Squamous Cell Carcinoma
CONCLUSION: Vascular invasion is a strong predictor of recurrence in stage IA2-IB LUAD but not in LUSC. Adjuvant therapy trials should be directed at this subgroup.PMID:36631388 | DOI:10.1016/j.cllc.2022.12.006
Source: Clinical Lung Cancer - January 11, 2023 Category: Cancer & Oncology Authors: Lubna Suaiti Travis B Sullivan Kimberly M Rieger-Christ Elliot L Servais Kei Suzuki Eric J Burks Source Type: research
Comparison of vascular leak syndrome in mice treated with IL21 or IL2.
Abstract
Interleukin 21 (IL21) is a T-cell-derived 4-helix-bundle cytokine that has sequence homology to the IL2 family. Recombinant human interleukin 2 (rIL2) is approved for the treatment of metastatic melanoma and renal cell carcinoma. However, toxicity of rIL2, including induction of vascular leak syndrome (VLS), has limited use of this cytokine to a small proportion of eligible patients. Both rIL2 and murine IL21 (mIL21) have potent antitumor efficacy in murine models. The purpose of the current study was to compare the ability of mIL21 and rIL2 to induce vascular leakage in a mouse model. Pulmonary and hepat...
Source: Comparative Medicine - February 1, 2013 Category: Zoology Authors: Sivakumar PV, Garcia R, Waggie KS, Anderson-Haley M, Nelson A, Hughes SD Tags: Comp Med Source Type: research
Wogonin influences vascular permeability via Wnt/β‐catenin pathway
In this study, we found that wogonin disrupted Wnt/β‐catenin signaling and reduced the secretion of vascular endothelial growth factor (VEGF, also known as vascular permeability factor, VPF), which increased vascular permeability in certain diseases. It was found that wogonin suppressed HUVECs hyperactivity and actin remodeling induced by hypoxia, inhibited transendothelial cell migration of the human breast carcinoma cell MDA‐MB‐231 and the extravasated Evans in vivo Miles vascular permeability assay. Wogonin‐treated cells showed a decrease in the expression of Wnt protein and its co‐receptors, as well as a par...
Source: Molecular Carcinogenesis - October 1, 2013 Category: Molecular Biology Authors: Xiuming Song, Yuxin Zhou, Mi Zhou, Yujie Huang, Zhiyu Li, Qidong You, Na Lu, Qinglong Guo Tags: Research Article Source Type: research
The effect of the anti‐angiogenic drug sunitinib malate on the vascular architecture of oral squamous cell carcinoma
ABSTRACT
The effects of anti‐angiogenic therapies in guiding tumor angioarchitecture prompted us to examine the modifications in the vascular network of the oral squamous cell carcinoma (SCC) produced by the multitargeted tyrosine kinase inhibitor sunitinib malate. Twelve Syrian hamsters had their right buccal pouches submitted to tumor induction with dimethylbenzanthracene and carbamide peroxide for 55 days. The animals were then divided into two groups of six animals each; group I was treated with sunitinib malate and group II (control) was remained untreated. After 4 weeks, the hamsters had their vascular networks cas...
Source: Microscopy Research and Technique - January 23, 2014 Category: Laboratory Medicine Authors: ViníCius Faccin Bampi, Carolina Ferreira Gomes, Laura Beatriz Oliveira Oliveira, Jefferson Luis Braga Silva Tags: Research Article Source Type: research
Diagnosis and surgical treatment of esophageal carcinoma with coexistent intrathoracic vascular malformations
ConclusionsThe coexistence of intrathoracic vascular malformations with esophageal carcinoma is rare, but easily missed in routine X‐ray and endoscopy. Enhanced chest CT must be performed to confirm. Surgery should be designed individually in consideration of the anatomic features of the vascular anomalies. A routine prophylactic ligation of the thoracic duct is recommended.
Source: Thoracic Cancer - August 25, 2014 Category: Cancer & Oncology Authors: Zhong‐Xi Niu, Qiang Gao, Jun Peng, Hui Shi, Long‐Qi Chen Tags: ORIGINAL ARTICLE Source Type: research
Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx
Conclusion Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.
Source: Brazilian Journal of Otorhinolaryngology - November 21, 2014 Category: ENT & OMF Source Type: research
Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.
CONCLUSIONS: The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers.
IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for thei...
Source: Journal of the Medical Library Association : JMLA - January 4, 2015 Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research
Upile T, Jerjes W, Radhi H, Al-Khawalde M, Kafas P, Nouraei S, Sudhoff H. Vascular mimicry in cultured head and neck tumour cell lines. Head Neck Oncol. 2011 Dec 23;3:55.
We present experimental evidence of vasculogenic mimicry in HNSCC cell lines and compare them with other tumours and a positive control vascular cell line.
Materials and methods
The cell lines used were HUVEC, HN 2a, 2b (primary and metastatic tongue base squamous carcinoma cell line), HCT116 (colonic carcinoma cell line) and DU145 (prostate carcinoma cell line).
Pilot experiments were undertaken to assess growth of a bank of tumour cell lines on (growth factor reduced) matrigel (Sigma) with standard media (DMEM with 10% Fetal Calf Serum).
A functional growth assay was performed by preparing the appropriate cell su...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Radiologic indicators prior to renal cell cancer thrombectomy: Implications for vascular reconstruction and mortality
Conclusion: Mayo risk factors did not predict vascular reconstruction in our small cohort of Level II–Level IV IVC thrombus undergoing IVC thrombectomy. Tumor thrombus traveling into the lumen of the hepatic veins was a significant risk factor for accelerated mortality.
Source: Urology Annals - June 28, 2016 Category: Urology & Nephrology Authors: Stephen OverholserOmer RaheemDavid ZapataDharam KaushikRonald RodriguezIthaar H DerweeshMichael A Liss Source Type: research
Substance P prevents vascular endothelial dysfunction in metastatic breast carcinoma.
In this study, cells derived from brain metastasis of 4T1 murine BCa (denoted as 4TBM) were used. Female Balb-c mice 8-10 weeks old were divided into following groups: (1) Control (Hanks' balanced salt solution injected), (2) injected with 4TBM orthotopically, (3) injected with 4TBM orthotopically and then treated with SP via an osmotic mini-pumps (0.1 mM, pumping rate 0.11 µl/hr). Thoracic aorta was removed 20-26 days after injection of tumor cells. Isometric tension studies were performed in response to potassium chloride, phenylephrine, acetylcholine (an endothelium-dependent vasodilator), and sodium nitroprus...
Source: Protein and Peptide Letters - September 1, 2016 Category: Biochemistry Authors: Dalaklioglu S, Erin N Tags: Protein Pept Lett Source Type: research
