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Cancer: Oral Cancer
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Oral cancer awareness and knowledge in adults attending a dental hospital in Northeast India
Conclusion The lack of basic awareness about the risk factors, causes, signs and symptoms of oral cancer in this cross-sectional population of Northeast India is clearly evident in our study. Since, Northeast India accounts for more than 40% of these cases, interactive cancer awareness programs should be taken up by research organizations and government to educate people and make them better understand the serious implications of oral cancer.
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research
Viral infection and oral habits as risk factors for oral squamous cell carcinoma in Yemen: a case-control study
The role of qat chewing, tobacco (shammah) dipping, smoking, alcohol drinking, and oral viral infection as risk factors for oral squamous cell carcinoma (OSCC) in Yemen was assessed.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 15, 2014 Category: ENT & OMF Authors: Akram T. Nasher, Nezar N. Al-hebshi, Ebtisam E. Al-Moayad, Ahmed M. Suleiman Tags: Oral medicine Source Type: research
Oral cancer in young Jordanians: potential association with frequency of narghile smoking
The aim of this study was to investigate the relationship between narghile (water-pipe) smoking and the age of patients when diagnosed with oral cancer.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 13, 2014 Category: ENT & OMF Authors: Suhail H. Al-Amad, Manal A. Awad, Omar Nimri Tags: Oral medicine Source Type: research
An appraisal of oral cancer and pre‐cancer screening programmes in Europe: a systematic review
ConclusionsIn order to uphold the benefits of screening, it is necessary to demonstrate an improvement in survival rates following early detection. No such randomised control trials (RCT) on OC have been undertaken in Europe. Undertaking such a RCT may be difficult in the European setting. However, the feasibility of screening for OPMDs by conventional oral examination has been demonstrated, supporting a strategy to adopt appropriate screening models, and further action from the European countries should be to demonstrate methods of halting their progression by tested interventions. We provide a brief guideline for future screening studies.
Source: Journal of Oral Pathology and Medicine - October 25, 2014 Category: Pathology Authors: Saman Warnakulasuriya, Nathalie Fennell, Pedro Diz, Juan Seoane, Alexander Rapidis, Tags: Review Article Source Type: research
Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy
Publication date: Available online 26 September 2014 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Naofumi Yamamoto , Shin-ichiro Masunaga , Itsuro Kato , Soichi Iwai , Mitsuhiro Nakazawa , Koji Ono , Yoshiaki Yura Low-intensity ultrasound has been shown to produce a transient pore on cell membranes and allow extracellular materials such as chemotherapeutic drugs, DNA and viruses to enter cells. Boron neutron capture therapy (BNCT) is a selective radiotherapy, if the 10B concentration is higher in the tumor than in normal tissue. The effect of ultrasound on the uptake of 10B carrier...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Clinical study of mode of invasion in tongue squamous cell carcinoma
Conclusion Patients with grade 4C/4D tumors had many poor prognostic factors, including a pN-positive rate of 73.5%, mortality, recurrence, and late metastasis rate of 44.2%. The tumors in this group exhibited both endophytic and exophytic growth patterns, and the 5-year-survival rate was significantly lower than that in patients with other grade tumors. These results suggest that grade 4C/4D is a useful prognostic factor.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Distant metastasis and survival of adenoid cystic carcinoma after definitive treatment
Conclusions ACC develops DM frequently even without locoregional recurrences. Only the status of surgical margins showed an association with the occurrence of DM. The survival of patients developing DM is significantly associated with the site of metastases and better in patients with lung compared to bone and other organs. A multimodality treatment approach including chemotherapy and molecular targets therapy is warranted to treat distant metastatic disease.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Dismal outcome of oral squamous cell carcinoma after successful loco-regional control: Distant metastasis to rare sites
Publication date: July 2014 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Volume 26, Issue 3 Author(s): Bhushan V. Jayade , Hari Kishore H. Bhat , K. Gopal Krishnan , Venkatesh Anehosur , Niranjan Kumar , Prasad P. Gunari The main risk factors for distant metastasis (DM) from oral squamous cell carcinoma (OSCC) are poor loco-regional control, location, T and N stage and histologic grade of the primary tumor. In this paper we present three cases of DM from OSCC that occurred within the first year of treatment despite radical management of the primary lesion and without any evidence of loco-reg...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Primary minor salivary gland salivary duct carcinoma at palate: A radiological investigation and review of the literature
We present here a single case of SDC arising from the minor salivary gland of a 82-year-old man. His first symptom was swelling on the left side of the palate. There is no bone resorption by the results of imaging studies, so benign tumor located in minor salivary gland was suspected. The tumor was dissected surgically and the intraductal component is microscopically described as a cribriform, papillary, solid growth pattern, with central necrosis. Immunohistochemical staining of intraductal component cells was positive for human epidermal growth factor receptor type2 (Her2), gross cystic disease fluid protein-15 (GCDFP-15...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Adjuvant chemoradiotherapy in an elderly patient with mandibular gingival spindle cell carcinoma with reference to an immunohistochemical study
We report on summary and immunohistochemical study, because we treated with adjuvant chemoradiotherapy therapy after surgery in an elderly patient with mandibular gingival SpCC. An 87-year-old woman visited a local dental clinic with a chief complaint of swelling of the right mandibular gingiva, and was referred to our department. Intraoral examination revealed a 24mm×13mm, elastic-soft, exophytic mass with a smooth, glistening, easily bleeding surface. Since PET–CT and MRI showed no findings suggestive of distant metastasis, tumor resection with marginal mandibulectomy was performed in September 2010, and histopatholog...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Carcinoma in-situ of the oral mucosa: Its pathological diagnostic concept based on the recognition of histological varieties proposed in the JSOP Oral CIS Catalog
Conclusion By referring to the Catalog, which explains histopathological variations, pathologists can more easily make a diagnosis of oral CIS, and oral surgeons can carry out appropriate clinical interventions for treating oral borderline malignancies.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Acinic cell carcinoma arising in the buccal mucosa: A case report of specific type of papillary-cystic variant
We report a case of acinic cell carcinoma arising in the left buccal mucosa of a 45-year-old male. On MRI findings, the tumor showed an oval, solid mass; however, during the surgical operation, a part of the tumor easily raptured by only finger pressure and the contents leaked out. The contents exhibited a grayish-brown color and mud-like consistency. Pathologically, the tumor showed a large cystic space. Some tumor cells included in the luminal side of cyst wall and the tumor cells partially protruded into the luminal space. The mud-like specimen revealed also tumor cells. These tumor cells were identified as typical sero...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - October 12, 2014 Category: ENT & OMF Source Type: research
Erlotinib: Lacking of Cholinergic Effects on Tracheal Smooth Muscle
This study demonstrated that erlotinib had no cholinergic effects in vitro, suggesting it may be safe for asthmatic patients with non-small-cell lung cancer after further investigation.
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research
Titanates Deliver Metal Compounds to Suppress Cell Metabolism
Conclusion The findings of the current study demonstrate that APT and MST alone significantly suppress the metabolism of a rapidly dividing cell line, an effect that is augmented by specific titanate-metal combinations. These compounds may have potential as unique therapeutic agents.
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research
Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells
This study is motivated by understanding and controlling the key physical properties underlying internalisation of nano drug delivery. We consider the internalisation of specific nanometre size delivery vehicles, comprised of self-assembling amphiphilic block copolymers, called polymersomes that have the potential to specifically deliver anticancer therapeutics to tumour cells. The possible benefits of targeted polymersome drug delivery include reduced off-target toxic effects in healthy tissue and increased drug uptake by diseased tissue. Through a combination of in vitro experimentation and mathematical modelling, we dev...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 4, 2014 Category: Nanotechnology Source Type: research
