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Can a Machine Learn from Radiologists ’ Visual Search Behaviour and Their Interpretation of Mammograms—a Deep-Learning Study
AbstractVisual search behaviour and the interpretation of mammograms have been studied for errors in breast cancer detection. We aim to ascertain whether machine-learning models can learn about radiologists ’ attentional level and the interpretation of mammograms. We seek to determine whether these models are practical and feasible for use in training and teaching programmes. Eight radiologists of varying experience levels in reading mammograms reviewed 120 two-view digital mammography cases (59 canc ers). Their search behaviour and decisions were captured using a head-mounted eye-tracking device and software allowing th...
Source: Journal of Digital Imaging - August 12, 2019 Category: Radiology Source Type: research
Re: It's All Relative: Assessing Online Search Interest in Genitourinary Cancer Awareness Campaigns
Patel and colleagues measured the Google Trends relative search volume (RSV) of prostate, testicular, and breast cancers to evaluate the success of men's health awareness campaigns to generate online interest. Based on significantly higher RSV for “breast cancer” during breast cancer awareness month relative to male cancers, they suggest that men's health awareness campaigns did not increase online search interest in prostate and testicular cancer. While we support using RSV to characterize online search patterns, we believe the conclusio ns about the failure of men's cancer awareness campaigns warrant additional context.
Source: Urology - April 4, 2020 Category: Urology & Nephrology Authors: Michael E. Rezaee, Kevin Koo Tags: Letters to the Editor Source Type: research
It's All Relative: Assessing Online Search Interest in Genitourinary Cancer Awareness Campaigns
Patel and colleagues measured the Google Trends relative search volume (RSV) of prostate, testicular, and breast cancers to evaluate the success of men's health awareness campaigns to generate online interest. Based on significantly higher RSV for “breast cancer” during breast cancer awareness month relative to male cancers, they suggest that men's health awareness campaigns did not increase online search interest in prostate and testicular cancer. While we support using RSV to characterize online search patterns, we believe the conclusio ns about the failure of men's cancer awareness campaigns warrant additional context.
Source: Urology - April 4, 2020 Category: Urology & Nephrology Authors: Michael E. Rezaee, Kevin Koo Tags: Letters to the Editor Source Type: research
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
CONCLUSIONS: The following literature review focuses on the discoveries made in ascertaining the different implications of miRNAs and candidate gene SNPs in the formation and evolution of brain AVMs, as well as highlighting the possible directions of future research and biological treatment.
ABBREVIATIONS: ACVRL1/ALK1: activin receptor-like kinase 1; Akt: protein kinase B; ANGPTL4: angiopoietin-like 4; ANRIL: antisense noncoding RNA in the INK4 locus; AVM: arteriovenous malformation; AVM-BEC: arteriovenous malformation brain endothelial cell; BRCA1: breast cancer type 1 susceptibility protein; CCS: case-control study; ...
Source: Neurological Research - July 31, 2020 Category: Neurology Tags: Neurol Res Source Type: research
Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization.
In this study, we found that intraosseous injection of simvastatin improves tumor vascular structure, along with increasing the percentage of pericyte coverage on tumor vessels, and reducing vascular permeability, tumor hypoxia and tumor necrosis. Further, we demonstrate that a single-dose local intraosseous simvastatin injection suppresses tumor growth, facilitates sensitivity of chemotherapy and prolongs survival in breast cancer-bearing mice. In addition, oral application, intravenous, subcutaneous and intraperitoneal injection of simvastatin do not show these effects. Taken together, these results demonstrate that intr...
Source: Translational Oncology - September 16, 2020 Category: Cancer & Oncology Authors: Yuan W, Hai B, Ren X, Zhu J, Zhang C, Guan Z, Jia J, Wang H, Cao B, Song C Tags: Transl Oncol Source Type: research
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Contributes to Tamoxifen Resistance in Estrogen-Positive Breast Cancer Patients
Mol Biol (Mosk). 2021 Jan-Feb;55(1):118-125. doi: 10.31857/S0026898421010055.ABSTRACTCrosstalk between the estrogen receptors and the receptor tyrosine kinases, including vascular endothelial growth factor receptor type II (VEGFR2), is a key mechanism in breast cancer resistance to antiestrogen therapy with tamoxifen. A high level of VEGFR2 expression in a tumor serves as a marker of tamoxifen resistance. The tamoxifen efficacy prognostic value of functional polymorphisms in the VEGFR2/KDR gene has not been established. Using qRT-PCR, we detected the rs2071559 and the rs2305948 variants and the levels of KDR gene expressio...
Source: Molekuliarnaia Biologiia - February 10, 2021 Category: Molecular Biology Authors: T A Dronova N N Babyshkina M V Zavyalova E M Slonimskaya N V Cherdyntseva Source Type: research
