Filtered By:
Cancer: Breast Cancer
This page shows you your search results in order of relevance. This is page number 7.
Order by Relevance | Date
Total 63313 results found since Jan 2013.
Breast cancer chemotherapy induces vascular dysfunction and hypertension through NOX4 dependent mechanism
J Clin Invest. 2022 May 26:e149117. doi: 10.1172/JCI149117. Online ahead of print.ABSTRACTCardiovascular disease is the major cause of morbidity and mortality in breast cancer survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long-term vascular dysfunction caused by neoadjuvant chemotherapy (NACT) and identify novel therapeutic targets.We studied arteries from postmenopausal women who had undergone breast cancer treatment using docetaxel, doxorubicin and cyclophosphamide (NACT), and women with no history of such treatment matched for key clinical parameters. Mechanisms were explored in ...
Source: Clinical Genitourinary Cancer - May 26, 2022 Category: Cancer & Oncology Authors: Piotr Szczepaniak Mateusz Siedlinski Diana Hodorowicz-Zaniewska Ryszard Nosalski Tomasz P Mikolajczyk Aneta M Dobosz Anna Dikalova Sergey Dikalov Joanna Streb Katarzyna Gara Pawel Basta Jaroslaw Krolczyk Joanna Sulicka-Grodzicka Ewelina Jozefczuk Anna Dzi Source Type: research
Atypical vascular lesions extending outside the radiation field: a diagnostic challenge
We report the first case of AVL occurring outside the field of radiation. This patient's clinical course and histopathology was overall consistent with AVL, including two biopsies with focal MYC positivity. However, due to variations in the interpretation of her histopathology, the management plans devised by two centers involved in her care were widely discordant and she was treated with chemotherapy and extensive surgery for angiosarcoma. Great care must be taken to distinguish between these entities, as treatment for angiosarcoma may be associated with significant morbidity.PMID:35499441 | DOI:10.5070/D3271256711
Source: Dermatol Online J - May 2, 2022 Category: Dermatology Authors: Alyssa Breneman Leah Hooey Kerith E Spicknall Debra L Breneman Source Type: research
Anti-angiogenic nano-delivery system promotes tumor vascular normalizing and micro-environment reprogramming in solid tumor
J Control Release. 2022 Jul 13:S0168-3659(22)00425-4. doi: 10.1016/j.jconrel.2022.07.015. Online ahead of print.ABSTRACTAberrant tumor vasculature leads to the malignant tumor microenvironment (TME) for tumor progression. Research has found temporary tumor vascular normalization after treated with low-dose anti-angiogenic agents, however, has paid little attention to prolonging the normalization window and its further influence on tumor tissue. Based on the dose- and time-dependent effect of anti-angiogenic agents, we developed V@LDL NPs, a nano-delivery system sustainedly releasing Vandetanib, an anti-VEGFR2 inhibitor, to...
Source: Cancer Control - July 16, 2022 Category: Cancer & Oncology Authors: Ruoyu Shen Lijun Peng Wentao Zhou Ding Wang Qi Jiang Jian Ji Fuqiang Hu Hong Yuan Source Type: research
Feasibility of Feature-based Indexing, Clustering, and Search of Clinical Trials. A Case Study of Breast Cancer Trials from ClinicalTrials.gov.
Conclusions: It is feasible to develop feature-based indexing and clustering methods for clinical trials to identify trials with similar target populations and to improve trial search efficiency.
PMID: 23666475 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - May 13, 2013 Category: Information Technology Authors: Boland MR, Miotto R, Gao J, Weng C Tags: Methods Inf Med Source Type: research
The Effect of Patient Narratives on Information Search in a Web-Based Breast Cancer Decision Aid: An Eye-Tracking Study
Conclusions: The observed increase in fixation duration with video patient testimonials is consistent with the idea that the vividness of the video content could cause greater elaboration of the message, thereby encouraging greater information search. Conversely, because reading requires more effortful processing than watching, reading patient narratives may have decreased participant motivation to engage in more reading in the remaining sections of the Web decision aid. These findings suggest that the format of patient stories may be equally as important as their content in determining their effect on decision making. Mor...
Source: Journal of Medical Internet Research - December 17, 2013 Category: Journals (General) Authors: Victoria A ShafferJustin OwensBrian J Zikmund-Fisher Source Type: research
Lipid–polymer nanoparticles encapsulating curcumin for modulating the vascular deposition of breast cancer cells
Abstract: Vascular adhesion and endothelial transmigration are critical steps in the establishment of distant metastasis by circulating tumor cells (CTCs). Also, vascular inflammation plays a pivotal role in steering CTCs out of the blood stream. Here, long circulating lipid–polymer nanoparticles encapsulating curcumin (NANOCurc) are proposed for modulating the vascular deposition of CTCs. Upon treatment with NANOCurc, the adhesion propensity of highly metastatic breast cancer cells (MDA-MB-231) onto TNF-α stimulated endothelial cells (HUVECs) reduces by ~70%, in a capillary flow. Remarkably, the CTCs vascular depositio...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - February 24, 2014 Category: Nanotechnology Authors: Anna L. Palange, Daniele Di Mascolo, Claudio Carallo, Agostino Gnasso, Paolo Decuzzi Tags: Pathology, Metastasis, Circulating Neoplastic Cells, Stimulating Adhesion, Curcumin, Lipid-Polymer NPs Source Type: research
Impact of vascular invasion of a primary tumor as a strong risk factor for disease recurrence in patients with node-positive breast cancer.
This study was undertaken to evaluate the presence of vascular invasion that may reflect systemic disease as a predictor of disease recurrence in node-positive breast cancer. We retrospectively evaluated the cases of 134 consecutive female patients with breast cancer with lymph node metastasis who underwent radical breast operations. We examined the relationship between recurrence and clinicopathological factors, particularly vascular invasion. The presence of vascular invasion was found to be significant in a univariate analysis. The presence of vascular invasion was the independent risk factor in a multivariate analysis....
Source: The American Surgeon - May 1, 2015 Category: Surgery Authors: Fujii T, Yajima R, Morita H, Hirakata T, Miyamoto T, Fujisawa T, Tsutsumi S, Ynagita Y, Iijima M, Kuwano H Tags: Am Surg Source Type: research
