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Total 12633 results found since Jan 2013.

Interaction between N < sup > 6 < /sup > -methyladenosine modification and the tumor microenvironment in colorectal cancer
Mol Med. 2023 Sep 22;29(1):129. doi: 10.1186/s10020-023-00726-2.ABSTRACTThe incidence and mortality of colorectal cancer (CRC) are rapidly increasing worldwide. Recently, there has been significant attention given to N6-methyladenosine (m6A), the most common mRNA modification, especially for its effects on CRC development. It is important to note that the progression of CRC would be greatly hindered without the tumor microenvironment (TME). The interaction between CRC cells and their surroundings can activate and influence complex signaling mechanisms of epigenetic changes to affect the survival of tumor cells with a malig...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Jiali Yao Yeke Song Xiaoping Yu Zhijie Lin Source Type: research

Research Progress and New Perspectives of Anticancer Effects of Emodin
In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.PMID:37732372 | DOI:10.1142/S0192415X23500787
Source: The American Journal of Chinese Medicine - September 21, 2023 Category: Complementary Medicine Authors: Wu Liu Eskandar Qaed Yuelin Zhu Wenzhang Tian Yizhen Wang Le Kang Xiaodong Ma Zeyao Tang Source Type: research

Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease
ConclusionsNuclear translocation of NRF2 was correlated with the magnitude of liver inflammation and fibrosis in chronic liver disease. These results suggest that NRF2 plays a protective role in the development of chronic liver diseases such as NASH and CHc.
Source: Cancer Medicine - September 21, 2023 Category: Cancer & Oncology Authors: Keii To, Kosuke Okada, Takahisa Watahiki, Hideo Suzuki, Kiichiro Tsuchiya, Katsutoshi Tokushige, Masakazu Yamamoto, Shun ‐ichi Ariizumi, Junichi Shoda Tags: RESEARCH ARTICLE Source Type: research

Cardiorespiratory fitness and BMI measured in youth and 5 ‐year mortality after site‐specific cancer diagnoses in men—A population‐based cohort study with register linkage
ConclusionWe report dose-dependent associations between CRF and BMI in youth and mortality after site-specific cancer diagnoses in men. The associations with mortality could be due to both cancer inhibition and an improved tolerance to withstand cancer treatment. These results strengthen the incentive for public health efforts aimed at establishing a high CRF and normal weight in youth.
Source: Cancer Medicine - September 21, 2023 Category: Cancer & Oncology Authors: Aron Onerup, Kirsten Mehlig, Elin Ekblom ‐Bak, Lauren Lissner, Mats Börjesson, Maria Åberg Tags: RESEARCH ARTICLE Source Type: research

Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer
ConclusionsThis data provides a rich resource for deeper studies of gastrointestinal malignancies. Newly identified splicing isoformTIMP1 Δ4-5 plays an important role in mediating CRC progression and may be a potential therapy target in CRC.
Source: Genome Medicine - September 21, 2023 Category: Genetics & Stem Cells Source Type: research

Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives?
In screening for colorectal cancer (CRC), colonoscopy is generally referred to as the ‘gold standard’, as it examines both the right and left colon. Despite wide adoption, colonoscopy had not been studied in randomised fashion until the Northern-European Initiative on Colorectal Cancer (NordICC) trial. NordICC is a pragmatic, registry-based, randomised controlled trial (RCT) of colonoscopy versus no screening in adults between 55 and 64.1 In NordICC, 84 000 participants were randomised (1:2) to either an invitation to colonoscopy or usual care, which, at the time of the study, was no CRC screening. The trial fo...
Source: Evidence-Based Medicine - September 21, 2023 Category: Internal Medicine Authors: Powell, K., Prasad, V. Tags: Open access EBM opinion and debate Source Type: research

Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
Curdione is a sesquiterpene isolated from Curcumae Rhizoma that possesses high biological activity and extensive pharmacological effects. As a traditional Chinese medicine, Curcumae Rhizoma can inhibit the develo...
Source: Chinese Medicine - September 21, 2023 Category: Complementary Medicine Authors: Fang Wang, Zheng Sun, Qunyao Zhang, Hao Yang, Gang Yang, Qi Yang, Yimiao Zhu, Wenya Wu, Wenwen Xu and Xiaoyu Wu Tags: Research Source Type: research

Retraction
Zhang Z, Tan X, Luo J, Cui B, Lei S, Si Z, Shen L, Yao H. GNA13 promotes tumor growth and angiogenesis by upregulating CXC chemokines via the NF- κB signaling pathway in colorectal cancer cells. Cancer Med. 2018;7(11):5611-5620.https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.1783. The above article, published online on September 28, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal's Editor-in-Chief, Dr Stephen Tait, and John Wiley& Sons Ltd. The retraction has been agreed due to evidence of image duplication between figures 3D, 3E, and 6C and fi...
Source: Cancer Medicine - September 20, 2023 Category: Cancer & Oncology Tags: RETRACTION Source Type: research

New gene markers detect Lynch syndrome-associated colorectal cancer, Mayo Clinic study
ROCHESTER, Minn. — Researchers from Mayo Clinic Comprehensive Cancer Center and Mayo Clinic Center for Individualized Medicine have discovered new genetic markers to identify Lynch syndrome-associated colorectal cancer with high accuracy. Studies are underway to determine if these genetic markers are in stool samp les and, if so, how this could lead to a non-invasive screening option for patients with Lynch syndrome. Their research was published in Cancer Prevention Research, a journal of the American Association…
Source: News from Mayo Clinic - September 20, 2023 Category: Databases & Libraries Source Type: news

Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation
ConclusionBZD treats CRC through multiple components, targets, and metabolic pathways. BZD can reverse the abnormal expression of genes such as PI3K, AKT, MYC, EGFR, HIF-1A, VEGFR, JUN, STAT3, CASP3, and TP53, and suppresses the progression of colorectal cancer by regulating signaling pathways such as PI3K-AKT, P53, and VEGF. Furthermore, BZD can increase the number of T cells and promote T cell activation in tumor-bearing mice, enhancing the immune function against colorectal cancer. Among them, quercetin, kaempferol, licochalcone A, naringenin, and formaronetin are more highly predictive components related to the T cell ...
Source: Frontiers in Immunology - September 20, 2023 Category: Allergy & Immunology Source Type: research

Automated Reminders Enhance Mailed Fecal Immunochemical Test Completion Among Veterans: a Randomized Controlled Trial
ConclusionsAutomated reminders increased colorectal cancer screening completion among average-risk veterans. An automated phone call or text message was equally effective. VHA facilities seeking to implement a mailed FIT program should consider using phone or text reminders, depending on available resources.
Source: Journal of General Internal Medicine - September 20, 2023 Category: Internal Medicine Source Type: research

The Relationship between Metformin Consumption and Cancer Risk: An Updated Umbrella Review of Systematic Reviews and Meta ‑Analyses
Conclusions: Treatment with metformin can significantly decrease the chance of all cancers with larger preventive effect on hepatocellular carcinoma and smaller preventive effect on lung and breast cancers.
Source: International Journal of Preventive Medicine - September 19, 2023 Category: International Medicine & Public Health Source Type: research

Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome
ConclusionsThis study identified several protein biomarkers to be associated with CRC risk and provided new insights into the etiology and promising targets for the development of screening biomarkers and therapeutic drugs for CRC.
Source: Genome Medicine - September 19, 2023 Category: Genetics & Stem Cells Source Type: research

Contribution of Metabolic Parameters and Pericolic Fat Stranding on Preoperative 18F-FDG PET/CT in Predicting Post-operative Histopathology and Outcome in Colorectal Cancer
CONCLUSION: Preoperative PET/CT contributes to CRC management by detecting additional metastases as well as predicting prognosis and postoperative findings such as T stage, N stage and tumor differentiation. The SUVmax may differentiate between T3 and T4 tumor. Reporting of pericolic fat stranding may contribute to the estimation of lymphatic invasion and positive surgical margin.PMID:37720878 | PMC:PMC10504194 | DOI:10.1007/s13139-023-00808-3
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Selin Soyluoglu Busra Ozdemir Gunay Source Type: research