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Molecular mechanism analysis of Miao medicine Jinwujiangu decoction in treating osteoarthritis based on a network pharmacology approach
CONCLUSIONS: The present study preliminarily analyzed the pharmacological mechanism of JWJG in treating OA on a network pharmacology approach and provided a great theoretical significance for clinical application.PMID:35848974 | DOI:10.19852/j.cnki.jtcm.20220519.002
Source: Journal of Traditional Chinese Medicine - July 18, 2022 Category: Complementary Medicine Authors: Jiang Zong Yao Xiaoling M A Wukai Tang Fang Source Type: research
Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis
AbstractUlcerative colitis (UC) is a chronic, non-specific intestinal disease that not only affects the quality of life of patients and their families but also increases the risk of colorectal cancer. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is an important component of inflammatory response system, and its activation induces an inflammatory cascade response that is involved in the development and progression of UC by releasing inflammatory cytokines, damaging intestinal epithelial cells, and disrupting the intestinal mucosal barrier. Chinese ...
Source: Chinese Journal of Integrative Medicine - April 29, 2023 Category: Internal Medicine Source Type: research
IL-10-dependent Effect of Chinese Medicine < em > Abelmoschus manihot < /em > on Alleviating Intestinal Inflammation and Modulating Gut Microbiota
Am J Chin Med. 2023 Jul 31:1-20. doi: 10.1142/S0192415X23500696. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a recurrent disease associated with a potential risk of colorectal cancer. Abelmoschus manihot (AM), a Chinese herbal medicine, is known to alleviate IBD. However, its mechanism of action requires further clarification. Here, we focused on the role of IL-10 and the gut microbiota in the mechanism of action of AM. The effects of AM on intestinal inflammation, mucus production, and gut microbes were evaluated in dextran sodium sulfate (DSS)-induced acute and chronic IBD models and in IL-10-defici...
Source: The American Journal of Chinese Medicine - July 30, 2023 Category: Complementary Medicine Authors: Cheng-Xi Li Yu-Meng Wang Wen-Jing Zhang Shu Zhang Jian-Ping Li Tong Zhou Jin-Ao Duan Jian-Ming Guo Source Type: research
