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Cancer: Colorectal Cancer

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Total 42474 results found since Jan 2013.

Stilbene 5c, A Microtubule Poison with Vascular Disrupting Properties That Induces Multiple Modes of Growth Arrest and Cell Death.
Abstract The stilbene derivative, cis-3, 4', 5-trimethoxy-3'-aminostilbene (stilbene 5c), is a potentially potent antitumor agent that acts via binding to the colchicine-binding site in tubulin. The current studies were designed to investigate the effectiveness of stilbene 5c against the HCT-116 human colon cancer cell line and B16/F10 melanoma cells as well as human endothelial cell formation and tumor perfusion. Stilbene 5c produced a time-dependent decrease in cell viability in both cell lines and the capacity of the cells to proliferate was not restored upon removal of the drug. Treatment with stilbene 5c also...
Source: Biochemical Pharmacology - October 18, 2013 Category: Drugs & Pharmacology Authors: Alotaibi MR, Asnake B, Di X, Beckman MJ, Durrant D, Simoni D, Baruchello R, Lee RM, Schwartz EL, Gewirtz DA Tags: Biochem Pharmacol Source Type: research

New approaches but the same flaws in the search of prognostic signatures.
Abstract A six-gene prognostic colorectal cancer hypoxia score was generated from expression data from in vitro experiments and microarray datasets and was validated in two distinct patient cohorts. The approach followed by the authors is original and biologically sound but could be limited by potential biases and other methodological limitations. PMID: 24583802 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - February 28, 2014 Category: Cancer & Oncology Authors: Salazar R, Tabernero J Tags: Clin Cancer Res Source Type: research

Assessment of vascular endothelial growth factor in formalin fixed, paraffin embedded colon cancer specimens by means of a well-based reverse phase protein array
Conclusions: The well-based RPPA method is a high throughput and sensitive approach, is an excellent tool for quantification of marker proteins. Notably, this method may be helpful for more objective evaluation of protein expression in cancer patients.
Source: Proteome Science - May 13, 2014 Category: Bioinformatics Authors: Joon-Yong ChungTill BraunschweigSeung-Mo HongDavid KwonSoo-Heang EoHyungJun ChoStephen Hewitt Source Type: research

Colorectal carcinomas in 2013: The search for powerful prognostic markers is still on the go!
Abstract Colorectal cancer (CRC) is the third cause of cancer worldwide after prostate cancer and breast cancer. Patients have a survival rate of 5 years, which varies between 10 and 95% depending on the CRC stage. Today, the management of patients with CRC is based on parameters such as TNM and classic histologic parameters, but new molecular and cell markers have been created to improve treatment and survival. Determining the expression of a characteristic set of genes either from formalin-fixed paraffin-embedded tissues (Onco type DX test™) or from fresh tissues (AGENDIA© ColoPrint®) has led to encouraging ...
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2014 Category: Cancer & Oncology Authors: Coget J, Borrini F, Susman S, Sabourin JC Tags: Cancer Biomark Source Type: research

Iodine-125 induces apoptosis via regulating p53, microvessel density, and vascular endothelial growth factor in colorectal cancer
Background: Iodine interstitial brachytherapy has been widely reported for treating colorectal cancer (CRC). However, the inhibitory molecular mechanism of iodine-125 (I-125) on CRC has not been reported. Methods: To illustrate the inhibitory mechanism of iodine-125 (I-125) on CRC, we established the animal models of CRC via the injection of HCT-8 cells into nude mice. Subsequently, the I-125 granules were implanted into the tumor of the animal model at different dosages. Proliferating cell nuclear antigen and terminal transferase dUTP nick end labeling were used to detect the apoptosis of the tumor cells. Immunohistochemi...
Source: World Journal of Surgical Oncology - July 17, 2014 Category: Cancer & Oncology Authors: Zhenhuan MaYong YangGuokai YangJia WanGuojian LiPing LuLingjuan Du Source Type: research

Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancer
Abstract Biglycan is an important component of the extracellular matrix, which belongs to the small leucine-rich proteoglycan family. Recent studies have shown that biglycan expression is elevated in many tumor tissues and implies poor prognosis, such as colon cancer. However, the molecular mechanism of biglycan in colon cancer has not been investigated. The present study aimed to investigate the effects of biglycan on vascular endothelial growth factor (VEGF) expression in colon cancer cells and on tumor angiogenesis in vivo. Biglycan overexpression vectors were constructed, and the stable biglycan overexpression...
Source: Tumor Biology - November 5, 2014 Category: Cancer & Oncology Source Type: research

Abstract 283: Biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (acts-cc): Correlation between gene expression and DNA copy number
Background: The ACTS-CC trial is a randomized, controlled phase III study designed to validate the noninferiority of S-1 to UFT/LV as adjuvant chemotherapy for stage III colon cancer and rectosigmoid cancer. A prospective biomarker search was performed as an auxiliary study of the ACTS-CC trial, using formalin-fixed, paraffin-embedded (FFPE) specimens obtained from 892 patients. The gene expression levels of 5-FU metabolizing enzymes and folate metabolizing enzymes and alterations of genome-wide copy numbers in tumor have been reported (2012 and 2013 Annual Meetings of AACR). In the present study, we performed correlation ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Uetake, H., Ishikawa, T., Ishiguro, M., Matsui, S., Sugihara, K., ACTS-CC Study Group Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Safety and Efficacy of Percutaneous Cecostomy/Colostomy for Treatment of Large Bowel Obstruction in Adults with Cancer
Conclusions Image-guided PC is safe and effective for management of functional and mechanical bowel obstruction in patients with cancer. For optimal efficacy, catheters should terminate within luminal gas.
Source: Journal of Vascular and Interventional Radiology - December 17, 2014 Category: Radiology Source Type: research

Systematic Search for Rare Variants in Finnish Early-Onset Colorectal Cancer Patients
Publication date: Available online 31 December 2014 Source:Cancer Genetics Author(s): Tomas Tanskanen , Alexandra E. Gylfe , Riku Katainen , Minna Taipale , Laura Renkonen-Sinisalo , Heikki Järvinen , Jukka-Pekka Mecklin , Jan Böhm , Outi Kilpivaara , Esa Pitkänen , Kimmo Palin , Pia Vahteristo , Sari Tuupanen , Lauri A. Aaltonen The heritability of colorectal cancer (CRC) is incompletely understood, and the contribution of undiscovered rare variants may be important. In search of rare disease-causing variants, we exome sequenced 22 CRC patients diagnosed before the age of 40 years. Exome equencing data from 95 famili...
Source: Cancer Genetics - December 31, 2014 Category: Cancer & Oncology Source Type: research

Long-Term Survival Following Percutaneous Radiofrequency Ablation of Colorectal Lung Metastases
Conclusions RF ablation of colorectal lung metastases provided favorable long-term survival with a low incidence of severe adverse events. Independent prognostic factors were a high CEA level before RF ablation and the presence of viable extrapulmonary recurrences at the time of RF ablation.
Source: Journal of Vascular and Interventional Radiology - January 21, 2015 Category: Radiology Source Type: research

Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial
Conclusions: The present study provides the new evidence that coating nanomaterials with more than one antibody against CTCs may effectively interfere with the interaction between SW620 and HUVECs.
Source: Journal of Nanobiotechnology - February 3, 2015 Category: Nanotechnology Authors: Jingjing XieHaiyan DongHongning ChenRongli ZhaoPatrick SinkoWeiyu ShenJichuang WangYusheng LuXiang YangFangwei XieLee Jia Source Type: research

1:00 PM Abstract No. 7 Y90 radioembolization of hepatic metastases of colorectal cancer using glass microspheres: survival and safety outcomes from a multicenter review of 531 patients
Conclusion Multicenter review of a large cohort of patients with colorectal cancer liver metastases treated with Y90 glass microspheres indicates that survival outcomes are not only consistent with but nearly identical to previous reports of patients treated with resin microspheres. The incidence of grade 3/4 liver toxicities is low. Treatment is well tolerated with adverse symptoms being low-grade and comparable among institutions.
Source: Journal of Vascular and Interventional Radiology - February 28, 2015 Category: Radiology Source Type: research

Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion
Colorectal cancer (CRC) is highly metastatic. Metastases spread directly into local tissue or invade distant organs via blood and lymphatic vessels, but the role of lymphangiogenesis in CRC progression has not been determined. Lymphangiogenesis is induced via vascular endothelial growth factor C (VEGFC) activation of its receptor, VEGFR3; high levels of VEGFC have been measured in colorectal tumors undergoing lymphangiogenesis, and correlated with metastasis. We investigated VEGFC signaling and lymphatic barriers in human tumor tissues and mice with orthotopic colorectal tumors.
Source: Gastroenterology - March 6, 2015 Category: Gastroenterology Authors: Carlotta Tacconi, Carmen Correale, Alessandro Gandelli, Antonino Spinelli, Elisabetta Dejana, Silvia D’Alessio, Silvio Danese Source Type: research

Modified Complete Mesocolic Excision With Central Vascular Ligation for the Treatment of Right-sided Colon Cancer: Long-term Outcomes and Prognostic Factors
Conclusions: We have successfully established the mCME technique, on the basis of the same principle as CME, but with a more tailored approach. The long-term oncologic outcomes and risk of postoperative morbidity were found to be comparable with those seen with the original CME procedure.
Source: Annals of Surgery - March 17, 2015 Category: Surgery Tags: Original Articles Source Type: research