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Cancer: Colorectal Cancer

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Total 42474 results found since Jan 2013.

Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer
ConclusionsLY3022856 was well tolerated up to a dose of 30  mg/kg qwk, but with minimal anti-tumor activity in CRC.ClinicalTrials.gov identifierNCT01288989.
Source: Cancer Chemotherapy and Pharmacology - August 25, 2016 Category: Cancer & Oncology Source Type: research

Selection of an early biomarker for vascular normalization using dynamic contrast-enhanced ultrasonography to predict outcomes of metastatic patients treated with bevacizumab
Conclusion The MTT evaluated with DCE-US at day 7 is significantly correlated to FFP of patients treated with bevacizumab. This criterion might be linked to vascular normalization. AFSSAPS No 2007-A00399-44.
Source: Annals of Oncology - September 25, 2016 Category: Cancer & Oncology Authors: Lassau, N., Coiffier, B., Kind, M., Vilgrain, V., Lacroix, J., Cuinet, M., Taieb, S., Aziza, R., Sarran, A., Labbe-Devilliers, C., Gallix, B., Lucidarme, O., Ptak, Y., Rocher, L., Caquot, L. M., Chagnon, S., Marion, D., Luciani, A., Feutray, S., Uzan-Augu Tags: oncology practice Source Type: research

Impact of Proximal Vascular Ligation on Survival of Patients with Colon Cancer
AbstractIn an effort to optimize further the surgical management of colon cancer, many groups have advocated extended lymphadenectomy as a strategy to improve completeness of resection and lymph node harvest. This review evaluates lymphadenectomy according to the definitions for extent of lymph node dissection based on the guidelines provided by the Japanese Society of Cancer of the Colon and Rectum and the contemporary concepts of complete mesocolic excision and central vascular ligation. The proposed benefits of a D3 or central nodal dissection along root vessels in colon cancer is improving accuracy of lymph node evalua...
Source: Annals of Surgical Oncology - December 8, 2016 Category: Cancer & Oncology Source Type: research

Microwave Ablation for Lung Neoplasms: A Retrospective Analysis of Long-Term Results
Conclusions This study further supports the safe and effective use of MW ablation for the treatment of lung tumors.
Source: Journal of Vascular and Interventional Radiology - December 17, 2016 Category: Radiology Source Type: research

Embolization for Bleeding after Hepatic Radiofrequency Ablation
Conclusions Embolization is safe and effective for controlling bleeding related to hepatic RF ablation without the need for surgery.
Source: Journal of Vascular and Interventional Radiology - December 21, 2016 Category: Radiology Source Type: research

Navigating the mesentery: Part II. Vascular abnormalities and a review of the literature
ConclusionVascular abnormalities occur frequently. Arterial abnormalities are a hazard when inadvertent injury occurs during surgery. Preoperative knowledge of a bifid SMV is useful.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - December 22, 2016 Category: Gastroenterology Authors: Jens Marius Nesgaard, Bojan V. Stimec, Arne Olav Bakka, Bjorn Edwin, Dejan Ignjatovic, Tags: Original Article Source Type: research

Bioavailability of aspirin in rats comparing the drug's uptake into gastrointestinal tissue and vascular and lymphatic systems: implications on aspirin's chemopreventive action.
We examined the time course for gastroduodenal uptake of aspirin and the appearance of its major metabolite salicylic acid in blood and lymph after intragastric (to simulate oral) and intraduodenal (to simulate enteric-coating) dosing in rats. Results show that after intragastric dosing, intact aspirin is absorbed primarily by the gastric mucosa and to a lesser extent by the duodenal mucosa. When aspirin is dosed intragastrically or intraduodenally, a much greater concentration of aspirin enters the lymph than the blood. In contrast, the concentration of salicylic acid was higher in blood than in lymph. Lymph levels of bot...
Source: J Physiol Pharmacol - September 30, 2016 Category: Drugs & Pharmacology Authors: Lichtenberger LM, Phan T, Fang D, Edler S, Philip J, Li-Geng T, Dial EJ Tags: J Physiol Pharmacol Source Type: research

Spontaneous Regression of Untreated Tumors with Immuno-Radiofrequency Ablation, RF Ablation in Combination with Local Injection of OK-432, in a Patient with Lung Metastases of Colon Cancer
Publication date: March 2017 Source:Journal of Vascular and Interventional Radiology, Volume 28, Issue 3 Author(s): Akira Yamamoto, Shinichi Hamamoto, Toshiyuki Matsuoka, Ken Kageyama, Atsushi Jogo, Etsuji Sohgawa, Tomohisa Okuma, Masao Hamuro, Masami Toyoshima, Joji Kawabe, Hisashi Nagahara, Yukio Miki
Source: Journal of Vascular and Interventional Radiology - February 21, 2017 Category: Radiology Source Type: research

The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.
Authors: Zheng HC, Liu JJ, Li J, Wu JC, Yang L, Zhao GF, Zhao X, Jiang HM, Huang KQ, Li ZJ Abstract Down-regulated parafibromin is positively linked to the pathogenesis of parathyroid, lung, breast, ovarian, gastric and colorectal cancers. Here, we found that wild-type (WT) parafibromin overexpression suppressed proliferation, tumor growth, induced cell cycle arrest and apoptosis in colorectal cancer cells (p<0.05), but it was the converse for mutant-type (MT, mutation in nucleus localization sequence) parafibromin (p<0.05). Both WT and MT transfectants inhibited migration and invasion, and caused better diff...
Source: Oncotarget - February 24, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Response to Miskovic: Re: No benefit of extended mesenteric resection with central vascular ligation in right ‐sided colon cancer
This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - March 1, 2017 Category: Gastroenterology Authors: Fredrik Olofsson, Pamela Buchwald, S ölve Elmståhl, Ingvar Syk Tags: Correspondence Source Type: research

Phase I trial and pharmacokinetic study of tanibirumab, a fully human monoclonal antibody to vascular endothelial growth factor receptor 2, in patients with refractory solid tumors
Conclusions Treatment with tanibirumab showed a tolerable toxicity profile and modest clinical efficacy in patients with refractory solid tumors. A phase II trial of tanibirumab is ongoing now.
Source: Investigational New Drugs - April 8, 2017 Category: Drugs & Pharmacology Source Type: research

Adjuvant Medications That Improve Survival after Locoregional Therapy
Conclusions Aspirin and beta-blockers are associated with significantly improved survival when taken at the time of embolization for HCC. Aspirin was not associated with survival differences after locoregional therapy for NET or colorectal liver metastases, suggesting an HCC-specific effect.
Source: Journal of Vascular and Interventional Radiology - May 19, 2017 Category: Radiology Source Type: research

Level of vascular tie and its effect on functional outcome two years after anterior resection for rectal cancer
ConclusionThis study does not support that the level of vascular tie influences the risk of major defecatory, urinary or sexual disturbances two years after anterior resection for rectal cancer.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - May 1, 2017 Category: Gastroenterology Authors: Daniel Kverneng Hultberg, Ashkan A. Afshar, J örgen Rutegård, Marilyne Lange, Markku M Haapamäki, Peter Matthiessen, Martin Rutegård Tags: Original Article Source Type: research

Totally Robotic Total Mesorectal Excision with High Vascular Tie for Rectal Cancer ‐ A Video Vignette
This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - September 20, 2017 Category: Gastroenterology Authors: Ilknur Erenler, Erman Aytac, Eren Esen, Ismail Ahmet Bilgin, Bilgi Baca, Ismail Hamzaoglu, Tayfun Karahasanoglu Tags: Correspondence Source Type: research

Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis
ConclusionA significant increase in VEGF expression was found to correlate with clinical symptoms and endoscopic rectal mucosa changes in patients with ChRP, suggesting that it may play an important role in pathological angiogenesis.This article is protected by copyright. All rights reserved.
Source: Colorectal Disease - September 29, 2017 Category: Gastroenterology Authors: Radzislaw Trzcinski, Adam Dziki, Magdalena Brys, Malgorzata Moszynska ‐Zielinska, Justyna Chalubinska‐Fendler, Michal Mik, Ryszard Kujawski, Lukasz Dziki Tags: Original Article Source Type: research