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Abstract CT211: Biomarker search using gene expression databases in a phase III controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene expression level
Conclusions: Location, differentiation and depth of the tumor correlated with each gene expressions. Our findings will facilitate understanding the characteristics of colon cancer. Further investigation on gene expressions including genome-wide copy number analysis may contribute to the exploration of valid biomarkers.Citation Format: Hiroyuki Uetake, Toshiaki Ishikawa, Megimi Ishiguro, Shigeyuki Matsui. Biomarker search using gene expression databases in a phase III controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gen...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Uetake, H., Ishikawa, T., Ishiguro, M., Matsui, S. Tags: Clinical Trials Source Type: research

Survival in Resected Stage II Colorectal Cancer Is Dependent on Tumor Depth, Vascular Invasion, Postoperative CEA Level, and The Number of Examined Lymph Nodes
Conclusions This study revealed that T4 invasion, vascular invasion, postoperative CEA level, and the number of examined lymph nodes may significantly affect the prognosis of stage II CRC patients after radical resection. The risks of postoperative early relapse and worse clinical outcome increase in proportion to the values of these four parameters.
Source: World Journal of Surgery - March 2, 2016 Category: Surgery Source Type: research

Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 31, 2017 Category: Cancer & Oncology Authors: Ryosuke Kamei, Hiroyoshi Y. Tanaka, Takao Kawano, Chiharu Morii, Sayaka Tanaka, Hiroshi Nishihara, Caname Iwata, Mitsunobu R. Kano Tags: Original Article Source Type: research

Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects.
Abstract A series of 14 analogs of the curcuminoid EF24, (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone, bearing fluorine or pentafluorothio substituents, were prepared and tested for antiproliferative, vascular-disruptive, and antiangiogenic activity, as well as for their influence on other cancer-relevant targets. They proved antiproliferative against eight cancer cell lines with IC50 values in the low single-digit micromolar to triple-digit nanomolar range. Like EF24, the hexafluoro 3c and 3d and bis(pentafluorothio) 4f derivatives arrested HT-29 colon carcinoma cells in G2/M phase of the cell cycle,...
Source: Bioorganic and Medicinal Chemistry - July 21, 2017 Category: Chemistry Authors: Schmitt F, Gold M, Begemann G, Andronache I, Biersack B, Schobert R Tags: Bioorg Med Chem Source Type: research

Vascular Invasion and Stromal S100A4 Expression at the Invasive Front of Colorectal Cancer are Novel Determinants and Tumor Prognostic Markers
Conclusion: Vascular invasion and stromal expression of S100A4 in the tumor budding areas correlated with patient survival. Stromal immunostaining of S100A4 may be useful for identifying high-risk patients with advanced CRC.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Tamotsu Sugai, Noriyuki Yamada, Makoto Eizuka, Ryo Sugimoto, Noriyuki Uesugi, Mitsumasa Osakabe, Kazuyuki Ishida, Kouki Otsuka, Akira Sasaki, Takayuki Matsumoto Tags: Research Paper Source Type: research

Role of Anti-Epidermal Growth Factor Receptor Therapy Compared with Anti-Vascular Endothelial Growth Factor Therapy for Metastatic Colorectal Cancer: an Update Meta-Analysis of Randomized Clinical Trials.
This study aimed to evaluate the impact of the combination of anti-epidermal growth factor receptor (anti-EGFR) therapy and anti-vascular endothelial growth factor therapy on mCRC patient outcomes by combining the data from randomized clinical trials. Three trials meeting the eligibility criteria, and four randomized studies were included in the meta-analysis. For MCRC patients with KRAS wild type (KRAS-WT), the ORR was superior in patients treated with anti-EGFR compared with those who treated with anti-VEGF therapy. This effect was even better for all RAS-WT patients. Progression-free survival (PFS) rates were not signif...
Source: Pathology Oncology Research - January 30, 2018 Category: Pathology Authors: Wang JX, Wu HL, Zhu M, Zhou R Tags: Pathol Oncol Res Source Type: research

Role of "Second Look" Lymph Node Search in Harvesting Optimal Number of Lymph Nodes for Staging of Colorectal Carcinoma.
Authors: Hamza A, Sakhi R, Khawar S, Alrajjal A, Edens J, Khurram MS, Khan U, Szpunar S, Mazzara P Abstract As with other malignancies, lymph node metastasis is an important staging element and prognostic factor in colorectal carcinomas. The number of involved lymph nodes is directly related to decreased 5-year overall survival for all pT stages according to United States Surveillance, Epidemiology, and End Results (SEER) cancer registry database. The National Quality Forum specifies that the presence of at least 12 lymph nodes in a surgical resection is one of the key quality measures for the evaluation of colorec...
Source: Gastroenterology Research and Practice - May 31, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF β), angiostatin, and endostatin are increased in radiotherapy-induced gastrointestinal toxicity.
CONCLUSIONS: Findings of this study support the involvement of VEGF, TGFβ, angiostatin, endostatin, and MMP-2 in the pathobiology of RIGT. However, the relationship between these mediators is complex and needs further investigation to improve understanding of their therapeutic potential in RIGT. PMID: 29855218 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - June 3, 2018 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials
Publication date: Available online 17 July 2018Source: The LancetAuthor(s): Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria Carla Roncaglioni, Takeshi Morimoto, Ziyah MehtaSummaryBackgroundA one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes.MethodsUsing individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm ...
Source: The Lancet - July 18, 2018 Category: General Medicine Source Type: research

JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF- α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor.
JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor. Eur J Pharmacol. 2019 Jul 10;:172532 Authors: Fukui K, Shinozaki Y, Kobayashi H, Deai K, Yoshiuchi H, Matsui T, Matsuo A, Matsushita M, Tanaka T, Nangaku M Abstract JTZ-951 (enarodustat) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor. JTZ-951 has inhibitory activities on human HIF-prolyl hydroxylase 1-3, but not on various receptors or enzymes. In Hep3B cells, JTZ-951 increased ...
Source: European Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Fukui K, Shinozaki Y, Kobayashi H, Deai K, Yoshiuchi H, Matsui T, Matsuo A, Matsushita M, Tanaka T, Nangaku M Tags: Eur J Pharmacol Source Type: research

Integrin β4 Is an Effective and Efficient Marker in Synchronously Highlighting Lymphatic and Blood Vascular Invasion, and Perineural Aggression in Malignancy
Lymphovascular invasion (LVI) and perineural invasion (PNI) are 2 important pathologic parameters and need to be accurately assessed in multiple malignancies. Integrin β4, a member of the integrin family, has been reported to be positively expressed in vascular endothelia, peripheral nerves, and a collection of epithelia. However, little is known about the effectiveness of β4 immunostaining on the recognition of LVI and PNI. Herein, we explored the applicability of β4 immunostaining in stomach, thyroid, and breast cancers. Parallel immunostaining of D2-40, CD34, and S-100 was performed as controls for lymphatic endothel...
Source: The American Journal of Surgical Pathology - April 15, 2020 Category: Pathology Tags: Original Articles Source Type: research

Cancers, Vol. 12, Pages 3311: Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers
a Ferreira Vidal Vivian Nogueira Silbiger Ândrea Ribeiro-dos-Santos The aberrant expression of microRNAs in known to play a crucial role in carcinogenesis. Here, we evaluated the miRNA expression profile of sigmoid colon cancer (SCC) compared to adjacent-to-tumor (ADJ) and sigmoid colon healthy (SCH) tissues obtained from colon biopsy extracted from Brazilian patients. Comparisons were performed between each group separately, considering as significant p-values < 0.05 and |Log2(Fold-Change)| > 2. We found 20 differentially expressed miRNAs (DEmiRNAs) in all comparisons, two of which were shar...
Source: Cancers - November 10, 2020 Category: Cancer & Oncology Authors: Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Ana Beatriz Bezerra-Oliveira Romualdo da Silva Correa Carlos Cesar de Oliveira Ramos Tatiana Vinasco-Sandoval Katia de Paiva Lopes Ricardo Assun ção Vialle Amanda Ferreira Vidal V Tags: Article Source Type: research

Technical considerations depending on the level of vascular ligation in laparoscopic rectal resection
ConclusionHT vascular ligation attempts to achieve tension-free anastomosis and more harvested lymph nodes. However, LT could be a preferred option, based on the lack of significant evidence for a difference in specific oncological survival and due to more accurate preservation of proximal intestinal segment microperfusion to prevent anastomosis dehiscence, also for its lower risk of damage to the hypogastric plexus. Splenic flexure mobilization provides elongation of the proximal intestinal segment, but has no proven effect on anastomotic leakage incidence. It increases surgical duration and is in fact necessary in up to ...
Source: Surgical Endoscopy - April 19, 2021 Category: Surgery Source Type: research

Preoperative evaluation of vascular anatomy of right colic vessels using enhanced computed tomographic colonography
ConclusionThis study elucidated the vascular anatomy and positional relationship with surrounding organs that is required in central vascular ligation during complete mesocolic excision for right sided colon cancer.
Source: Japanese Journal of Radiology - January 23, 2022 Category: Radiology Source Type: research

Full Laparoscopic Vascular Reconstruction for Portal Tumoral Invasion During a Right Hepatectomy Using the Caudal Approach
ConclusionsIn selected cases, patients who require vascular resection and reconstruction during hepatectomies can benefit from the advantages of a laparoscopic approach.
Source: Annals of Surgical Oncology - June 4, 2022 Category: Cancer & Oncology Source Type: research