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Neuro-Ophthalmic Manifestations of Acute Leukemia
Conclusions: Neuro-ophthalmic manifestations of leukemia may occur as presenting features of diagnosis, relapse, or CNS involvement, and portend a poor prognosis. Detection of neuro-ophthalmic involvement often triggers a prompt change in management. Therefore, familiarity with potential neuro-ophthalmic presentations of acute leukemia may avoid delayed diagnosis, and resultant inadequate treatment, of primary disease, relapse, or CNS involvement.
Source: Journal of Neuro-Ophthalmology - November 22, 2021 Category: Opthalmology Tags: Original Contribution Source Type: research

Diagnosis of Acute Promyelocytic Leukemia After Presentation to Neuro-Ophthalmology
Conclusion: Neuro-ophthalmologic symptoms may be the first manifestations of APML, and a complete blood count is an essential test in patients presenting with optic disc edema, especially if hemorrhagic.
Source: Journal of Neuro-Ophthalmology - February 25, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy
A successful therapeutic paradigm established historically in oncology involves combining agents with potentially complementary mechanisms of antitumor activity into rationally designed regimens. For example, cocktails of cytotoxic agents, which were carefully designed based on mechanisms of action, dose, and scheduling considerations, have led to dramatic improvements in survival including cures for childhood leukemia, Hodgkin's lymphoma, and several other complex cancers. Outcome for glioblastoma, the most common primary malignant CNS cancer, has been more modest, but nonetheless our current standard of care derives from...
Source: Neuro-Oncology - October 29, 2015 Category: Cancer & Oncology Authors: Reardon, D. A., Gilbert, M. R., Wick, W., Liau, L. Tags: Articles Source Type: research

P13.05 Success Rate and Early Morbidity from Image-Guided Ommaya Reservoir Placement for Intraventricular Chemotherapy: Case Series and Systematic Review
Conclusions:Our findings suggest improved accuracy and decreased complications using an image-guided approach compared with a traditional approach. Our results support routine use of intra-operative image guidance for proximal catheter insertion in elective Ommaya reservoir placement for intraventricular chemotherapy.
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Lau, J. C., Macdonald, D. R., Megyesi, J. F. Tags: P13 Brain and leptomeningeal metastases Source Type: research

Endogenous SOLOIST/MRTFB i4, a neuronal isoform of MKL2/MRTFB, positively and negatively regulates SRF target immediate early genes in Neuro-2a cells
Biol Pharm Bull. 2023 Jun 8. doi: 10.1248/bpb.b22-00851. Online ahead of print.ABSTRACTMegakaryoblastic leukemia (MKL2)/myocardin-related transcription factor-B (MRTFB) is a serum response factor (SRF) that is enriched in the brain and controls SRF target genes and neuronal morphology. There are at least four isoforms of MKL2/MRTFB. Among these, MKL2/MRTFB isoform 1 and spliced neuronal long isoform of SRF transcriptional coactivator (SOLOIST)/MRTFB isoform 4 (MRTFB i4) are highly expressed in neurons. Although, when overexpressed in neurons, isoform 1 and SOLOIST/MRTFB i4 have opposing effects on dendritic morphology and ...
Source: Biological and Pharmaceutical Bulletin - June 7, 2023 Category: Drugs & Pharmacology Authors: Daisuke Ihara Hiroki Tanabe Ichiro Takasaki Akiko Tabuchi Source Type: research

Cognitive Impairment Associated with Cancer: A Brief Review
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research

The Population - Based Survey of Paraneoplastic Neurological Syndromes in the Czech Republic during the Eight Years' Period (P3.323)
Conclusions: Results of this population - based survey characterize profile of PNS and emphasize some rarities as atypical long-term course questioning some aspects of diagnostic criteria and unusual association between limbic encephalitis and CLL without onconeural antibodiesDisclosure: Dr. Stourac has nothing to disclose. Dr. Bednarova has nothing to disclose. Dr. Praksova has nothing to disclose. Dr. Hladikova has nothing to disclose. Dr. Kantorova has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Stourac, P., Bednarova, J., Praksova, P., Hladikova, M., Kantorova, K. Tags: Neuro-oncology: Paraneoplastic Syndromes and Other Antibody-Mediated Disorders Source Type: research

Nt-05 * patient acceptance of routine resampling of glioblastoma: a qualitative study
CONCLUSIONS: Using qualitative research methodology, we can learn insights about patients' experience that we cannot learn from quantitative research. This information can help us learn: 1) what our patients are feeling; 2) how we can better talk to them; 3) what issues are important to them to talk about; 4) how we can improve their care and their perception of care; and 5) how we can better conduct clinical research. This can lead to improvement in the quality of our neuro-oncology patients' experience and help facilitate the practice of patient-centered care for brain tumor patients. This particular study demonstrates t...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Bernstein, M., Dirks, P., Mason, W., Mir, T. Tags: NOVEL THERAPEUTICS (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Neuro-Immune Interactions at Barrier Surfaces
Publication date: 5 May 2016 Source:Cell, Volume 165, Issue 4 Author(s): Henrique Veiga-Fernandes, Daniel Mucida Multidirectional interactions between the nervous and immune systems have been documented in homeostasis and pathologies ranging from multiple sclerosis to autism, and from leukemia to acute and chronic inflammation. Recent studies have addressed this crosstalk using cell-specific targeting, novel sequencing, imaging, and analytical tools, shedding light on unappreciated mechanisms of neuro-immune regulation. This Review focuses on neuro-immune interactions at barrier surfaces—mostly the gut, but also incl...
Source: Cell - May 5, 2016 Category: Cytology Source Type: research

Demographic profile, clinicopathological spectrum, and treatment outcomes of primary central nervous system tumors: Retrospective audit from an academic neuro-oncology unit
Tejpal Gupta, Sridhar Epari, Aliasgar Moiyadi, Prakash Shetty, Jayant Sastri Goda, Rahul Krishnatry, Girish Chinnaswamy, Tushar Vora, Hari Menon, Vijay Patil, Ayushi Sahay, Nazia Bano, Rakesh JalaliIndian Journal of Cancer 2017 54(4):594-600 Primary tumors of the central nervous system are relatively uncommon, comprising only 1%–2% of all neoplasms. However, they constitute the second most common type of malignancy in children (after leukemia) and the leading cause of cancer-related morbidity and mortality in children and young adults worldwide. Globally, there is substantial variability...
Source: Indian Journal of Cancer - July 30, 2018 Category: Cancer & Oncology Authors: Tejpal Gupta Sridhar Epari Aliasgar Moiyadi Prakash Shetty Jayant Sastri Goda Rahul Krishnatry Girish Chinnaswamy Tushar Vora Hari Menon Vijay Patil Ayushi Sahay Nazia Bano Rakesh Jalali Source Type: research