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Cancer: Leukemia

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Clinical Predictors of Port Infections in Adult Patients with Hematologic Malignancies
ConclusionsIn adult patients with hematologic malignancies, hypoalbuminemia at the time of port placement was a clinical predictor for early port infections, whereas steroid use was a clinical predictor for overall port infections.
Source: Journal of Vascular and Interventional Radiology - July 10, 2018 Category: Radiology Source Type: research

Immunosuppressive therapy in myelodysplastic syndromes: a borrowed therapy in search of the right place.
Authors: Shallis RM, Chokr N, Stahl M, Pine AB, Zeidan AM Abstract INTRODUCTION: Myelodysplastic syndromes (MDS) encompass a heterogenous collection of clonal hematopoietic stem cell disorders defined by dysregulated hematopoiesis, peripheral cytopenias, and a risk of leukemic progression. Increasing data support the role of innate and adaptive immune pathways in the pathogenesis and disease course of MDS. The role of immunosuppressive therapy has an established role in the treatment of other hematologic diseases such as aplastic anemia whose pathogenesis is postulated to reflect that of MDS with regards to many as...
Source: Expert Review of Hematology - July 21, 2018 Category: Hematology Tags: Expert Rev Hematol Source Type: research

Acute promyelocytic leukemia cell adhesion to vascular endothelium is reduced by heparins
In conclusion, we show that LMWH significantly counteract APL cell adhesion to the vessel wall, by modulating EC adhesion molecule expression. This property of heparins may represent one approach for hampering excess clotting activation and microthrombi deposition in APL.
Source: Annals of Hematology - August 6, 2018 Category: Hematology Source Type: research

Vascular Niche E-Selectin Promotes Acute Myeloid Leukemia Resistance to Chemotherapy via Its Receptors CD44 and CD162
In this study we characterized mechanisms behind this niche-mediated chemoresistance.
Source: Experimental Hematology - August 1, 2018 Category: Hematology Authors: Johanna Erbani, Valerie Barbier, Jessica Lowe, Joshua Tay, Jean-Pierre Levesque, Ingrid Winkler Source Type: research

Features of vascular adverse events in Japanese patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: a retrospective study of the CML Cooperative Study Group database
In conclusion, incidence of IHD requires closer monitoring in nilotinib-treated patients. More detailed investigations for determining the most useful tool to predict VAE incidence and long-term analysis of therapy-related VAE cases are needed for improving safety during TKI therapy.
Source: Annals of Hematology - October 5, 2018 Category: Hematology Source Type: research

New role for protein could lead to novel treatments for cancer and vascular disease
(York University) Researchers at York University have found a new role for a well-known protein in the body that may explain, in part, what goes wrong in certain cancers, as well as vascular and neurological disorders.Beta-catenin, a wide-ranging and important protein for the regulation of cell function from the embryonic stage to adulthood, has already been implicated in the development of certain cancers, including colon, breast, leukemia and melanoma.
Source: EurekAlert! - Biology - October 25, 2018 Category: Biology Source Type: news

Vascular Access Device Complications during Induction Chemotherapy for AML: A Single Institutional Analysis
Conclusion: In patients undergoing induction chemotherapy for AML, the choice of VAD was associated with different levels of risk of BSI and DVT. The lowest overall BSI rate was with PICC. When adjusted for BSI due to skin flora or fungi, PICC and TDL were similar. The combined risk of BSI and DVT was lowest with PICC, however, if only accounting for BSI due to skin flora or fungi, then TDL was the safest. A lower rate of line associated DVT risk may be achieved with a tunneled VAD compared to PICC. This data suggests that dual lumen PICC or TDL are the optimal VAD for induction chemotherapy in AML patients.Figure 1. Skin ...
Source: Blood - November 21, 2018 Category: Hematology Authors: Macari, D., Gbadamosi, B., Ezekwudo, D. E., Anderson, J., Jaiyesimi, I., Stender, M. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster II Source Type: research

Reduction of blood pressure elevation by losartan in spontaneously hypertensive rats through suppression of LARG expression in vascular smooth muscle cells
ConclusionThe study results showed that the reduction of BP elevation by losartan in SHRs occurs through the suppression of LARG expression and MYPT-1 phosphorylation in vascular smooth muscle cells.
Source: Journal of the Formosan Medical Association - April 6, 2019 Category: General Medicine Source Type: research

In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees
Leukemia, Published online: 28 January 2020; doi:10.1038/s41375-019-0702-7In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees
Source: Leukemia - January 27, 2020 Category: Hematology Authors: Alexander Pemov Anand Pathak Samantha J. Jones Ramita Dewan Jessica Merberg Sirisha Karra Jung Kim Evgeny Arons Sarangan Ravichandran Brian T. Luke Shalabh Suman Meredith Yeager Belynda D. Hicks Amy H. Hutchinson Michelle Manning Aurelie Vogt Kristine Jon Source Type: research

Cancers, Vol. 12, Pages 678: N-Ethyl-n-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis
This study investigated the mechanism of leukaemogenic effects of n-ethyl-n-nitrosourea (ENU) in a mouse model. A total of 14 3-week-old male Institute of Cancer Research (ICR)-mice were used for the study. The mice were divided into groups A and B with seven mice each. Group A served as the control while group B received intraperitoneal (IP) injections of 80 mg/kg ENU twice with a one-week interval and were monitored monthly for 3 months for the development of leukaemia via blood smear examination. The mice were sacrificed humanely using a CO2 chamber. Blood, spleen, lymph nodes, liver, kidney and lung samples were collec...
Source: Cancers - March 12, 2020 Category: Cancer & Oncology Authors: Abdullahi Aliyu Mohd Rosly Shaari Nurul Syahirah Ahmad Sayuti Mohd Farhan Hanif Reduan Shanmugavelu Sithambaram Mustapha Mohamed Noordin Khozirah Shaari Hazilawati Hamzah Tags: Article Source Type: research

Vascular events may predict the prognosis of patients with chronic myeloid leukemia.
PMID: 32533516 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - June 11, 2020 Category: Hematology Authors: Ureshino H, Kamachi K Tags: Int J Hematol Source Type: research

The expression and significance of leukemia inhibitory factor, interleukin-6 and vascular endothelial growth factor in Chinese patients with endometriosis
ConclusionThe LIF, IL-6 and VEGF levels in blood and peritoneal fluid were increased in patients with endometriosis, and increased LIF and IL-6 in ectopic endometriosis stromal cells can play a synergistic role in increasing the VEGF levels, which may be involved in the occurrence and development of endometriosis.
Source: Archives of Gynecology and Obstetrics - February 8, 2021 Category: OBGYN Source Type: research

Serum Levels of Vascular Endothelial Growth Factor and Its Receptor in Newly Diagnosed Paediatric Acute Lymphoblastic Leukemia
AbstractAutocrine and paracrine loop involving vascular endothelial growth factor (VEGF) and its receptor have been described in haematological malignancies. However, scarce literature is present on angiogenesis in paediatric acute lymphoblastic leukemia (ALL) with studies showing controversial results. The aim was to study serum levels of VEGF and its receptors in paediatric ALL at the time of diagnosis and at the end of induction phase and to compare these levels with clinico-haematological parameters in these patients. Serum VEGF, VEGFR-1 and VEGFR-2 levels were measured by enzyme-linked immunoabsorbant assay at diagnos...
Source: Indian Journal of Hematology and Blood Transfusion - February 23, 2021 Category: Hematology Source Type: research

DCE-MRI quantification of leukemia-induced changes in bone marrow vascular function
Haematologica. 2021 Mar 25. doi: 10.3324/haematol.2020.277269. Online ahead of print.ABSTRACTNot available.PMID:33764000 | DOI:10.3324/haematol.2020.277269
Source: Haematologica - March 25, 2021 Category: Hematology Authors: Ana L Gomes John Gribben Bernard Siow Diana Passaro Dominique Bonnet Source Type: research