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Cancer: Lymphoma
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Total 9108 results found since Jan 2013.
Variants in XPC, Noxa and TLR4 genes are not associated with bleomycin-induced lung injury in Hodgkin lymphoma patients
Personalized Medicine, Ahead of Print.
Source: Future Medicine: Personalized Medicine - April 21, 2020 Category: Genetics & Stem Cells Authors: Dimpal N Thakkar Indumathi Prapath Subathra Adithan Kesavan Ramasamy Sandhiya Selvarajan Biswajit Dubashi Source Type: research
PM2.5 Linked to Later Mortality in Certain Pediatric, AYA Cancers
Mortality risk increased at 5 years, 10 years among those with pediatric lymphomas, CNS tumors
Source: Pulmonary Medicine News - Doctors Lounge - November 11, 2014 Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Oncology, Pathology, Pediatrics, Pulmonology, Journal, Source Type: news
Parameters on interim 18F-FDG PET are strong predictors of survival, independent of clinical prognostic indexes and biological markers, in patients with diffuse large B cell lymphoma
Conclusions: SUVmax at iPET4 was independently prognostic for both PFS and OS in DLBCL treated with RCHOP. Patients with residual disease at iPET2 who subsequently achieve CR by iPET4 have excellent outcomes. References: 1. Dührsen U, Müller S, Hertenstein B, Thomssen H, Kotzerke J, Mesters R et al. Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial. Journal of Clinical Oncology. 2018;36(20):2024-2034. 2. Lin C, Itti E, Haioun C, Petegnief Y, Luciani A, Dupuis J et al. Early 18F-FDG PET for Prediction of Prognosis in Patients with Dif...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Lee, S. T., Wai, S. H., Shen, E., Wight, J., Fancourt, T., Berlangieri, S., Scott, A., Hawkes, E., Geoff, C. Tags: Leukemia/Lymphoma/Myeloma Source Type: research
Ensemble 3D Convolutional Neural Networks for Automated Detection of Diseased Lymph Nodes
Conclusions: An ensemble of 3D convolutional neural networks was able to detect diseased lymph nodes at a performance approaching the interobserver variability of two physicians in a large dataset of heterogeneous lymphoma lesions. Acknowledgements: This work was supported by GE Healthcare.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Weisman, A., Kieler, M., Perlman, S., Jeraj, R., Hutchings, M., Kostakoglu, L., Bradshaw, T. Tags: Data Sciences (Poster Session) Source Type: research
Computer-aided detection of mantle cell lymphoma in whole body 18F-FDG PET/CT using deep convolutional neural networks
Conclusions: Deep CNNs can help identify MCL lesions with high sensitivity and limited PPV on baseline whole body 18F-FDG PET/CT. Our constructed CNNs were also robust among images from outside institutions and therefore may become a highly useful tool in the detection and initial staging of MCL. Table 1. Characteristics of patients in the training and testing groups.CharacteristicTrainingTestingNo. of included patients11530Mean age ± standard deviation57 ± 8 years56 ± 9 yearsSex (male : female)90 : 2522 : 8Source of the scan (within : outside institution)91 : 2423 : 7Scanner vendor (GE : Siemens)96 : ...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Zhou, Z., Xu, G., Son, J. B., Ma, J. Tags: Data Sciences (Poster Session) Source Type: research
Machine learning-based assignment of Deauville scores is comparable to interobserver variability on interim FDG PET/CT images of pediatric lymphoma patients
Conclusions: A fully automated method for assigning Deauville scores on interim PET scans was developed using a dataset from a multi-institutional prospective clinical trial of pediatric HL patients. Performance comparable to interobserver variability of visual DS was found for five class labeling. Binary DS classification results were more difficult to replicate, however validation in larger datasets including more patients with interim PET DS less than 3 is needed. Acknowledgements: This work was partially supported by GE Healthcare. We would also like to thank IROC-Rhode Island for their assistance with image transfers.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Weisman, A., Lee, I., Im, H., McCarten, K., Kessel, S., Schwartz, C., Kelly, K., Santoro-Fernandes, V., Jeraj, R., Cho, S., Bradshaw, T. Tags: Data Sciences (Poster Session) Source Type: research
Genome ‐wide DNA methylome analysis reveals methylation subtypes with different clinical outcomes for acute myeloid leukemia patients
In conclusion, we identified AML methylation subtypes and their marker genes, these results may help to excavate potential targets for clinical therapy and the development of precision medicine for AML patients.
Source: Cancer Medicine - July 5, 2020 Category: Cancer & Oncology Authors: Haiyan Gao,
Xin He,
Qiang Li,
Ying Wang,
Yaoyao Tian,
Xi Chen,
Jinghua Wang,
Yan Guo,
Wei Wang,
Xiaoyun Li Tags: ORIGINAL RESEARCH Source Type: research
Management of orbital inflammatory disorders in internal medicine: New findings resulting from a retrospective study of 31 consecutive patients.
CONCLUSION: After ruling out auto-immune orbital diseases, especially IgG4 ROD, IOIS should be discussed. Factors conditioning the corticosteroid response are yet to be determined.
PMID: 32861532 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - September 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Comparison of 11 automated PET segmentation methods in lymphoma.
ConclusionsMultiple methods, including a 3D CNN, clustering, and an iterative threshold method, achieved both good lesion-level segmentation and patient-level quantification performance in a population of 90 lymphoma patients. These methods are thus recommended over thresholding methods such as 40% and 50% SUVmax, which were consistently found to be significantly outside the limits defined by inter-physician agreement.
PMID: 32906088 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - September 8, 2020 Category: Physics Authors: Weisman AJ, Kieler M, Perlman S, Hutchings M, Jeraj R, Kostakoglu Shields L, Bradshaw TJ Tags: Phys Med Biol Source Type: research
Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine.
Authors: Lodhi N, Tun M, Nagpal P, Inamdar AA, Ayoub NM, Siyam N, Oton-Gonzalez L, Gerona A, Morris D, Sandhu R, Suh KS
Abstract
Despite the great efforts for better treatment options for diffuse large B-cell lymphoma (DLBCL) (most common form of non-Hodgkin lymphoma, NHL) to treat and prevent relapse, it continues to be a challenge. Here, we present an overview of DLBCL and address the diagnostic assays and molecular techniques used in its diagnosis, role of biomarkers in detection, treatment of early and advanced stage DLBCL, and novel drug regimens. We discuss the significant biomarkers that have emerged as esse...
Source: Oncotarget - November 21, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Neurology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Absent Superficial Abdominal Reflex due to thoracic spinal cord neuromyelitis. NEJM, 05/2014.Kayser-Fleischer Rings in Wilson ' s Disease. NEJM, 03/2012.Perilymph Fistula Test leads to nystagmus. NEJM, 01/2012.A stray bullet in the brain - with no deficit of power, cognition, sense of touch, or speech. Lancet, 01/2012.Blindness after Fat Injections. NEJM, 12/2011.Internal-Carotid-Artery Dissection and Cranial-Nerve Palsies. NEJM, 12/2011.A Head Shot. NEJM, 12/2011.Multiple Intracranial Tuberculomas. NEJM, 10/2011....
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Neurology Source Type: news
Corrigendum Anticancer effect of quinacrine on diffuse large B ‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway.
[Corrigendum] Anticancer effect of quinacrine on diffuse large B‑cell lymphoma via inhibition of MSI2‑NUMB signaling pathway.
Mol Med Rep. 2021 Mar;23(3):
Authors: Yang S, Sheng L, Xu K, Wang Y, Zhu H, Zhang P, Mu Q, Ouyang G
Abstract
Subsequently to the publication of this paper, an interested reader drew to the authors' attention that, in Fig. 1A on p. 524, the images selected to represent the Control experiments for the SU‑DHL‑8 and OCI‑Ly01 cell lines bore some striking similarities. After having examined their original data, the authors realized that they uploaded the wrong images du...
Source: Molecular Medicine - January 7, 2021 Category: Molecular Biology Authors: Yang S, Sheng L, Xu K, Wang Y, Zhu H, Zhang P, Mu Q, Ouyang G Tags: Mol Med Rep Source Type: research
New frontiers in precision medicine for Sjogren's syndrome.
Authors: Chatzis L, Vlachoyiannopoulos PG, Tzioufas AG, Goules AV
Abstract
Introduction: Sjögren's syndrome is a unique systemic autoimmune disease, placed in the center of systemic autoimmunity and at the crossroad of autoimmunity and lymphoproliferation. The diverse clinical picture of the disease, the inefficacy of current biologic treatments and the co-existence with lymphoma conferring to the patients' morbidity and mortality, force the scientific community to review disease pathogenesis and reveal the major implicated cellular and molecular elements. Areas covered: Biomarkers for early diagnosis, prediction,...
Source: Expert Review of Clinical Immunology - January 24, 2021 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Just another “Clever Hans”? Neural networks and FDG PET-CT to predict the outcome of patients with breast cancer
ConclusionAlthough trained on lymphoma and lung cancer, PARS showed good accuracy in the detection of PERCIST measurable lesions. Therefore, the neural network seems not prone to the clever Hans effect. However, the network has poor accuracy if all manually segmented lesions were used as reference standard. Both the whole body and organ-wise MTV were significant prognosticators of overall survival in advanced breast cancer.
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 5, 2021 Category: Nuclear Medicine Source Type: research
Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Qingdu Decoction against Chronic Liver Injury
CONCLUSIONS: QDD has protective effect against CLI, which may be related to the regulation of hepatocyte apoptosis. This study provides novel insights into exploring potential biological basis and mechanisms of clinically effective formula systematically.PMID:33747110 | PMC:PMC7952185 | DOI:10.1155/2021/6661667
Source: Evidence-based Complementary and Alternative Medicine - March 22, 2021 Category: Complementary Medicine Authors: Chongyang Ma Mengpei Zhao Yuqiong Du Shuang Jin Xiaoyi Wu Haiyan Zou Qiuyun Zhang Lianyin Gao Source Type: research
