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Total 25233 results found since Jan 2013.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): MRI
Discussionby Dr MGK Murthy, Dr GA PrasadChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized clinically by a progressive or relapsing course of many months to years of symptoms similar to compressive myelopathy.Etiology Remains unknown, but T-cell activation in nerves plays an important role in the pathogenesis of CIDP& antigens in Schwann cells have been identified.PathologicallyCIDP is characterized by mononuclear cell infiltrates, edema, segmental demyelination, and remyelination&“onion bulb formation” which describes enlarged fascicles with increased endoneural connective t...
Source: Sumer's Radiology Site - December 12, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Computer-aided search for 5-arylideneimidazolone anticancer agents able to overcome ABCB1-based multidrug resistance
ChemMedChem. 2021 Apr 30. doi: 10.1002/cmdc.202100252. Online ahead of print.ABSTRACTABCB1 modulation is an interesting strategy in search for new anticancer agents overcoming multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing amine moiety, as potential ABCB1 inhibitors was designed, synthesized, and investigated. The series was tested in both, parental (PAR) and multidrug resistant (MDR) overproducing ABCB1, T-lymphoma cancer cells using cytotoxicity assay. The ABCB1 modulating activity was examined in the rhodamine 123 accumulation test, followed by Pgp-Glo™ Assay to determine an influence of ...
Source: ChemMedChem - April 30, 2021 Category: Chemistry Authors: Aneta Kaczor Nikoletta Szemer édi Katarzyna Kucwaj-Brysz Monika D ąbrowska Ma łgorzata Starek Gniewomir Latacz Gabriella Spengler Jadwiga Handzlik Source Type: research

CD177 Expression on Neutrophils: In Search of a Clonal Assay for Myeloid Neoplasia by Flow Cytometry.
Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. PMID: 24124144 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - October 15, 2013 Category: Pathology Authors: Meyerson HJ, Osei E, Schweitzer K, Blidaru G, Edinger A, Balog A Tags: Am J Clin Pathol Source Type: research

The Search for Surrogate Endpoints in Trials in Diffuse Large B-Cell Lymphoma: The Surrogate Endpoints for Aggressive Lymphoma Project.
PMID: 28798271 [PubMed - as supplied by publisher]
Source: The Oncologist - August 10, 2017 Category: Cancer & Oncology Authors: Sargent DJ, Shi Q, Flowers CR, Schmitz N, Habermann TM, Flament J, Fu T, Coiffier B, SEAL group Tags: Oncologist Source Type: research

Does maintenance therapy have a role in mantle cell lymphoma treatment?
Authors: Parrott M, Rule S Abstract INTRODUCTION: Mantle cell lymphoma (MCL) is a rare but often aggressive B-cell non-Hodgkin lymphoma (NHL). Initial therapy can achieve high response rates but invariably patients relapse and die from their disease. Incorporating a maintenance phase into the treatment strategy may prolong remission duration and ultimately prolong survival. Areas covered: The current literature incorporating a maintenance phase into treatment strategies for newly diagnosed and pre-treated MCL patients has been summarized. A literature search was performed using search terms "mantle cell lymphoma", ...
Source: Expert Review of Hematology - March 10, 2018 Category: Hematology Tags: Expert Rev Hematol Source Type: research

Molecules, Vol. 25, Pages 2258: Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance
a Handzlik Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (groups A and B), were designed and obtained in a three- or four-step synthesis, involving the Dimroth rearrangement. The new compounds were tested for their inhibition of the ABCB1 efflux pump in both sensitive (parental (PAR)) and ABCB1-overexpressing (MDR) T-lymphoma cancer cells in a rhodamine 123 accumulation assay...
Source: Molecules - May 10, 2020 Category: Chemistry Authors: Aneta Kaczor M árta Nové Annam ária Kincses Gabriella Spengler Ewa Szyma ńska Gniewomir Latacz Jadwiga Handzlik Tags: Article Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research

IJERPH, Vol. 18, Pages 4008: Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.
Source: International Journal of Environmental Research and Public Health - April 11, 2021 Category: Environmental Health Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Tags: Article Source Type: research

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.PMID:33920383 | DOI:10.3390/ijerph18084008
Source: Clinical Lymphoma and Myeloma - April 30, 2021 Category: Cancer & Oncology Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Source Type: research

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma
Eur J Med Chem. 2022 Sep 19;243:114761. doi: 10.1016/j.ejmech.2022.114761. Online ahead of print.ABSTRACTLymphomas are still difficult to treat even with modern therapies as, among others, multidrug resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters are well-known for their crucial role in the main tumour MDR mechanism, eliminating drugs and cytotoxic substances from the cancer cell by efflux, and their modulators are promising for innovative therapy, but none has been approved in the pharmaceutical market yet. Herein, we have designed, synthesised and analysed 30 novel seleno- and t...
Source: European Journal of Medicinal Chemistry - September 30, 2022 Category: Chemistry Authors: Wesam Ali Sabrina Garbo Annam ária Kincses M árta Nové Gabriella Spengler Elisabetta Di Bello Ewelina Honkisz-Orzechowska Tadeusz Karcz Ewa Szyma ńska Ewa Żesławska Ma łgorzata Starek Monika D ąbrowska Wojciech Nitek Katarzyna Kucwaj-Brysz Patryk Source Type: research

Chronic inflammatory demyelinating polyneuropathy and malignancy: A systematic review
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - December 1, 2017 Category: Internal Medicine Authors: Yusuf A. Rajabally, Shahram Attarian Tags: Invited Review Source Type: research

AIDS-associated upper motor neuron disease with unique radiographic findings (P2.307)
Conclusions:HIV associated nervous system pathology is extremely varied and can mimic many other infectious and non-infectious etiologies and an exhaustive differential diagnosis for AIDS related upper motor neuron disease will be provided. The striking abnormalities observed on MR imaging of upper motor neuron pathways were distinctly unusual. It is important to keep a broad differential diagnosis in the HIV-infected patient.Disclosure: Dr. Pulst-Korenberg has nothing to disclose. Dr. Khella has received personal compensation for activities with Alnylam and Novartis. Dr. Khella has received research support from CIDP and ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pulst-Korenberg, J., Khella, S., Berger, J. Tags: HIV, HTLV-I, PML, Other Viral Infections, and CJD Source Type: research