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Opioid-Sparing Effects of Topical Ketamine in Treating Severe Pain From Decubitus Ulcers.
Authors: Skavinski KA Abstract Pain from pressure ulcers can severely impact a patient's quality of life. Evidence-based treatment of ulcer-related pain typically relies on systemic opioids with limiting side effects. Literature exists on the use of topical ketamine for neuropathic pain, but not for tissue injury in general and for decubitus ulcer pain specifically. Ketamine has a number of actions including blocking of the glutamate NMDA ionophore in the periphery. Preclinical evidence suggests that NMDA receptors located on peripheral sensory afferent terminals may play a role in initiating pain signaling in infl...
Source: Journal of Pain and Palliative Care Pharmacotherapy - February 1, 2019 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Medical Management of Pediatric Malignant Bowel Obstruction in a Patient with Burkitt's Lymphoma and Ataxia Telangiectasia Using Continuous Ambulatory Drug Delivery System.
The objective of this report is to demonstrate conservative management of pediatric MBO using continuous ambulatory drug delivery system. The patient was initiated on continuous ambulatory drug delivery (CADD) system for symptom relief. MBO was reversed with conservative management and the child was discharged on self-collapsible portable elastomeric continuous infusion pump under the supervision of a local family physician. The child remained comfortable at home for 4 weeks until his death. His parents were satisfied with the child's symptom control, quality of life, and were able to care for the child at home. In a resou...
Source: Journal of Pain and Palliative Care Pharmacotherapy - February 12, 2016 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Pruritic Manifestation of Peripheral T Cell Lymphoma Effectively Managed with Mirtazapine: A Case Report.
We report a patient with diffuse, chronic pruritus secondary to peripheral T Cell Lymphoma (PTCL) who had same day response to mirtazapine after a litany of other agents were unsuccessful. PMID: 32118497 [PubMed - as supplied by publisher]
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 3, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

The Case Files: Masquerading Shoulder Pain
Weinstein, Shannon DO; Saadatmand, Babak MD; Sattler, Steven DO; Levy, David DO   A 62-year-old woman with a past medical history of breast cancer presented to the emergency department with three weeks of intermittent left scapula pain. The onset was at rest, and she had no history of trauma. The pain was not made worse or relieved by change in position. She denied any associated symptoms, but a review of systems revealed a few episodes of abdominal fullness over the preceding three weeks.   She denied chest pain, shortness of breath, abdominal pain, nausea, vomiting, diarrhea, fever, chills, leg pain or swelling, and re...
Source: The Case Files - October 19, 2012 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Multimodal Analgesia in Pediatric Cancer Pain Management: A Retrospective Single-Center Study
Conclusions The pain level that pediatric cancer patients endure critically influences their and their family's quality of life. The fact that opioid-related adverse effects associated with pediatric pain management occur far less frequently than previously thought may help prevent opiophobia. Effective and safe analgesia can be provided with multimodal analgesia to manage pediatric cancer pain.PMID:37720121 | PMC:PMC10501176 | DOI:10.7759/cureus.45223
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Mesut Bak ır Şebnem Rumeli Argun Pire Source Type: research

Patient ‐reported neuropathic pain in adolescent and young adult cancer patients
ConclusionsNeuropathic pain occurs in one in four adolescents and young adults receiving cancer therapy. Use of screening tools may increase the detection of neuropathic pain in adolescents and young adults receiving cancer therapy and could ultimately improve pain treatment.
Source: Pediatric Blood and Cancer - November 27, 2016 Category: Cancer & Oncology Authors: Melissa A. Acquazzino, Eva C. Igler, Mahua Dasgupta, Pippa Simpson, Meghen B. Browning, Amanda M. Brandow Tags: Research Article Source Type: research

Interest of repetitive transcranial magnetic stimulation of the motor cortex in the management of refractory cancer pain in palliative care: Two case reports.
CONCLUSION: In the context of palliative care of cancer patients experiencing refractory pain that is difficult to control by the usual treatments, motor cortex repetitive transcranial magnetic stimulation, due to its noninvasive nature, can be used as an adjuvant therapy to improve various components of pain, including the emotional components. By reducing the doses of analgesics, repetitive transcranial magnetic stimulation decreases the severity of their adverse effects and improves the patient's quality of life. PMID: 25739966 [PubMed - as supplied by publisher]
Source: Palliative Medicine - March 4, 2015 Category: Palliative Care Authors: Nizard J, Levesque A, Denis N, de Chauvigny E, Lepeintre A, Raoul S, Labat JJ, Bulteau S, Maillard B, Buffenoir K, Potel G, Lefaucheur JP, Nguyen JP Tags: Palliat Med Source Type: research

The effect of foot reflexology on fatigue, pain, and sleep quality in lymphoma patients: A clinical trial.
CONCLUSION: The results showed that reflexology could reduce fatigue and pain and improve the quality of sleep in patients with lymphoma. Considering the effectiveness of reflexology in lymphoma patients, healthcare workers including nurses are recommended to use this complementary therapy to reduce fatigue and pain and improve sleep quality in lymphoma patients. PMID: 31669916 [PubMed - as supplied by publisher]
Source: European Journal of Oncology Nursing - October 17, 2019 Category: Nursing Authors: Rambod M, Pasyar N, Shamsadini M Tags: Eur J Oncol Nurs Source Type: research

Quality of Life and Pain Experienced by Children and Adolescents With Cancer at Home Following Discharge From the Hospital
An exploratory study was conducted to examine the quality of life and pain experienced by patients with pediatric cancer at home after discharge. Physical, cognitive, social, and emotional aspects of quality of life were measured and how these may be affected by age, sex, diagnosis, and pain status. The authors also characterized intensity, location, and quality of pain experienced. A sample of 33 patients participating in a larger study was selected on the basis of having pain on the day of discharge and having completed the Pediatric Quality of Life Inventory Generic, Cancer Module, Multidimensional Fatigue Scale, and th...
Source: Journal of Pediatric Hematology Oncology - December 19, 2019 Category: Hematology Tags: Original Articles Source Type: research

The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer.
Authors: Richard SA, Kampo S, Sackey M, Hechavarria ME, Buunaaim ADB Abstract Scorpion Buthus martensii Karsch -analgesic-antitumor peptide (BmK AGAP) has been used to treat diseases like tetanus, tuberculosis, apoplexy, epilepsy, spasm, migraine headaches, rheumatic pain, and cancer in China. AGAP is a distinctive long-chain scorpion toxin with a molecular mass of 7142 Da and composed of 66 amino acids cross-linked by four disulfide bridges. Voltage-gated sodium channels (VGSCs) are present in excitable membranes and partakes in essential roles in action potentials generation as compared to the significant funct...
Source: Evidence-based Complementary and Alternative Medicine - November 13, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A novel minimally invasive wireless technology for neuromodulation via percutaneous intercostal nerve stimulation (PNS) for post ‐herpetic neuralgia: A case report with short‐term follow‐up
ConclusionsSubcutaneous placement of electrodes with our minimally invasive technique and wireless neuromodulation technology was safe and effective. Significant improvements in pain relief ensued and at the end of 3 month‐ follow up without any adverse events.This article is protected by copyright. All rights reserved.
Source: Pain Practice - June 1, 2017 Category: Anesthesiology Authors: Bart Billet, Roel Wynendaele, Niek E. Vanquathem Tags: Case Report Source Type: research

Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch
Conclusions This study ’s computer-aided drug discovery approach yielded a new Nav1.7 inhibitor that shows analgesic and anti-pruritic activity in mouse models.Editor ’s PerspectiveWhat We Already Know about This TopicThe Nav1.7 sodium ion channel is of critical importance to pain perception and itch in humansSelective Nav1.7 blockers have not become clinically available for use in pain managementWhat This Article Tells Us That Is NewIn silico screening identified several potential Nav1.7 blocking compoundsThe combined use of electrophysiology and behavioral pharmacology demonstrated that one compound, DA-0218, was a p...
Source: Anesthesiology - August 13, 2020 Category: Anesthesiology Source Type: research

Pain and quality of life in patients undergoing radiotherapy for spinal metastatic disease treatment
Conclusion: Radiotherapy with supportive treatment appears to be an important tool for the treatment of pain in patients with spinal metastatic disease.
Source: International Archives of Medicine - February 18, 2013 Category: Global & Universal Authors: Edgar Valesin FilhoLuiz de AbreuGuilherme LimaDaniel de CuberoFabrício UenoGustavo FigueiredoVitor ValentiCarlos MonteiroRubens WajnsztejnEdison FujikiModesto NetoLuciano Rodrigues Source Type: research