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Lycopene supplementation protects vascular dementia gerbils against the impairment of learning and memory
In this study, we investigated the neuroprotective effects of lycopene (Lyc) on vascular dementia (VaD) gerbils and its related mechanisms of anti-inflammatory, anti-apoptotic and anti-oxidant activity. Gerbils were treated with bilateral common carotid arteries. Animals were divided into 1) Sham, 2) VaD model, and 3) VaD model + Lyc (20 mg/kg) groups. Each group (3) was administered intergalactic Lyc twice a day for 28 days. Morris water mazes were used to evaluate learning and memory ability. Nissl, NeuN, and GFAP staining were used to observe histomorphological changes of neural and glial cells in the hippocampus CA1 re...
Source: Folia Neuropathologica - July 21, 2021 Category: Pathology Authors: Wei Chen Jianwu Zhang Jing Wang Yunxiang Li Wenhu Liu Jun Xia Source Type: research