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Total 12650 results found since Jan 2013.

Should reflectance confocal microscopy be the gold standard for basal cell carcinoma diagnosis?
Imaging in Medicine , August 2013, Vol. 5, No. 4, Pages 299-301.
Source: Future Medicine: Imaging in Medicine - August 2, 2013 Category: Radiology Tags: article Source Type: research

Elevated PRAME expression: what does this mean for treatment of head and neck squamous cell carcinoma?
Biomarkers in Medicine , August 2013, Vol. 7, No. 4, Pages 575-578.
Source: Future Medicine: Biomarkers in Medicine - August 2, 2013 Category: Internal Medicine Tags: article Source Type: research

CYFRA21-1 as a serum tumor marker for follow-up patients with squamous cell lung carcinoma and oropharynx squamous cell carcinoma
Biomarkers in Medicine , August 2013, Vol. 7, No. 4, Pages 591-599.
Source: Future Medicine: Biomarkers in Medicine - August 2, 2013 Category: Internal Medicine Tags: article Source Type: research

Genetic Alterations and Personalized Medicine in Melanoma: Progress and Future Prospects
High-throughput sequencing technologies are providing new insights into the genetic alterations involved in melanomagenesis. It appears likely that most genetic events important in the pathogenesis of melanoma will be discovered over the next few years. Genetic analysis is also increasingly being used to direct patient care. In parallel with the discovery of new genes and the elucidation of molecular pathways important in the development of melanoma, therapies targeting these pathways are becoming available. In other words, the age of personalized medicine has arrived, characterized by molecular profiling of melanoma to id...
Source: JNCI - February 7, 2014 Category: Cancer & Oncology Authors: Griewank, K. G., Scolyer, R. A., Thompson, J. F., Flaherty, K. T., Schadendorf, D., Murali, R. Tags: Review Source Type: research

Comment Melanoma as a model for precision medicine in oncology
Advances in the understanding of the molecular profile of tumour cells and progress in systems biology and bioinformatics have led to the promise of precision medicine for treatment of human cancer. Melanoma has provided an opportunity for insights into both the potential benefit and limitations of precision medicine for cancer.
Source: The Lancet Oncology - March 1, 2014 Category: Cancer & Oncology Authors: Howard L Kaufman Tags: Comment Source Type: research

Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
Conclusions: KZE induced melanogenesis by increasing the expression of TYR, TRP-1, TRP-2 and MITF in B16 cells.
Source: BMC Complementary and Alternative Medicine - May 22, 2014 Category: Complementary Medicine Authors: Adila TuerxuntayiYong-qiang LiuAblajan TulakeMaidina KabasEblimit AidenHaji Aisa Source Type: research

Highlights from the field of biomarkers in melanoma
Biomarkers in Medicine June 2014, Vol. 8, No. 5, Pages 617-619.
Source: Future Medicine: Biomarkers in Medicine - August 15, 2014 Category: Internal Medicine Tags: article Source Type: research

Translational Genomics and Head and Neck Cancer: Toward Precision Medicine.
Abstract Head and neck squamous cell carcinoma (HNSCC) comprise a wide spectrum of neoplasms with different tumor biologies, prognosis and response to therapies. Current tumor classification and traditional diagnostic methods (e.g. clinical assessment, histopathology) are limited in their capacity to determine prognosis and clinical decision-making. Despite recent improvements in treatment, the outcome for patients with HNSCC remains poor. Like most tumors, several patient-related factors, (e.g. genetics and environment) and disease-related factors (e.g. tumor location, TMN staging) play a significant role on surv...
Source: Clinical Genetics - August 21, 2014 Category: Genetics & Stem Cells Authors: Razzouk S Tags: Clin Genet Source Type: research

Uncovering influence links in molecular knowledge networks to streamline personalized medicine
Conclusions Applications of the RIIG formalism demonstrated its potential to uncover patient-specific complex relationships among biological entities to find effective drug targets in a personalized medicine setting. We conclude that RIIG provides an effective means not only to streamline morphoproteomic studies, but also to bridge curated biomedical knowledge and causal reasoning with the clinical data in general. Graphical abstract
Source: Journal of Biomedical Informatics - November 13, 2014 Category: Information Technology Source Type: research

Researchers urge stronger warning for indoor tanning risks
(University of Colorado Denver) The US Surgeon General should declare that indoor ultraviolet radiation tanning causes skin cancer, according to an article published today by the American Journal of Preventive Medicine.Robert P. Dellavalle, MD, PhD, MSPH, associate professor of dermatology at the University of Colorado School of Medicine, is the corresponding author of the article, which says there is enough evidence for the Surgeon General to clearly state that use of indoor tanning beds causes skin cancer.
Source: EurekAlert! - Medicine and Health - April 8, 2015 Category: Global & Universal Source Type: news

Cell migration and adhesion of a Human melanoma cell line Is decreased by cold plasma treatment
Publication date: Available online 27 May 2015 Source:Clinical Plasma Medicine Author(s): Anke Schmidt , Sander Bekeschus , Thomas von Woedtke , Sybille Hasse Treatment of tumor metastasis continues to be of major importance in the field of cancer medicine. The biological responses of the human melanoma cancer cell line SK-Mel-147 after exposure to cold plasma-treated medium were investigated. Plasma reduced tumor cell motility and colony formation while cell metabolism, apoptosis, and cell cycle progression were less affected. Plasma treatment was associated with an inhibition of migration and disorganization of the act...
Source: Clinical Plasma Medicine - May 29, 2015 Category: Research Source Type: research

Personalized cancer immunotherapy using Systems Medicine approaches.
Abstract The immune system is by definition multi-scale because it involves biochemical networks that regulate cell fates across cell boundaries, but also because immune cells communicate with each other by direct contact or through the secretion of local or systemic signals. Furthermore, tumor and immune cells communicate, and this interaction is affected by the tumor microenvironment. Altogether, the tumor-immunity interaction is a complex multi-scale biological system whose analysis requires a systemic view to succeed in developing efficient immunotherapies for cancer and immune-related diseases. In this review...
Source: Briefings in Bioinformatics - July 14, 2015 Category: Bioinformatics Authors: Gupta SK, Jaitly T, Schmitz U, Schuler G, Wolkenhauer O, Vera J Tags: Brief Bioinform Source Type: research

Penn scientists identify key genetic factor that keeps moles from turning into melanoma
(University of Pennsylvania School of Medicine) Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.
Source: EurekAlert! - Medicine and Health - August 5, 2015 Category: Global & Universal Source Type: news

Abstract 2432: A technology platform for personalized medicine in melanoma
We developed patient derived xenografts (PDX), performed whole exome sequencing (WES) and analyzed circulating tumor DNA (ctDNA) to complement clinical management of four melanoma patients. Synchronous treatment of patients and mice showed that PDX responses mirrored those of the patients’ tumor to BRAF inhibitors. PDXs were used to test second-line treatments in relapsed patients and to validate WES-based therapies in tumors that did not have a BRAF mutation. Longitudinal analysis of ctDNA was predictive of responses to targeted and immunotherapies, and to determine mechanisms of resistance. Thus, we describe a powerful...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Girotti, M. R., Rothwell, D., Viros, A., Mandal, A. K., Lim, K. H. J., Gremel, G., Furney, S., Pedersen, M., Rogan, J., Swan, J., Fusi, A., Brady, G., Lorigan, P., Dive, C., Marais, R. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Metronomic Reloaded: Theoretical Models Bringing Chemotherapy into the Era of Precision Medicine
Publication date: Available online 7 September 2015 Source:Seminars in Cancer Biology Author(s): Sébastien Benzekry, Eddy Pasquier, Dominique Barbolosi, Bruno Lacarelle, Fabrice Barlési, Nicolas André, Joseph Ciccolini Oncology has benefited from an increasingly growing number of groundbreaking innovations over the last decade. Targeted therapies, biotherapies, and the most recent immunotherapies all contribute to increase the number of therapeutic options for cancer patients. Consequently, substantial improvements in clinical outcomes for some disease with dismal prognosis such as lung carcinoma or melanoma ha...
Source: Seminars in Cancer Biology - September 10, 2015 Category: Cancer & Oncology Source Type: research