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Vascular Endothelial Growth Factor is a Useful Predictor of Postoperative Distant Metastasis and Survival Prognosis in Esophageal Squamous Cell Carcinoma
Conclusions Expression of VEGF is a predictor of distant metastasis, OS, and DMFS in resectable ESCC patients. Using a combination of VEGF expression, tumor stages, and tumor cell grade, identification of patients with increased risk of postoperative metastases may become possible.
Source: Annals of Surgical Oncology - February 5, 2015 Category: Cancer & Oncology Source Type: research

Double-Blinded, Randomized Phase II Study Using Embolization with or without Granulocyte–Macrophage Colony-Stimulating Factor in Uveal Melanoma with Hepatic Metastases
Conclusions Immunoembolization induced more robust inflammatory responses, which correlated with the delayed progression of extrahepatic systemic metastases.
Source: Journal of Vascular and Interventional Radiology - February 10, 2015 Category: Radiology Source Type: research

Metadherin Regulation of Vascular Endothelial Growth Factor Expression Is Dependent Upon the PI3K/Akt Pathway in Squamous Cell Carcinoma of the Head and Neck
Abstract: Our previous study indicated overexpression of metadherin (MTDH) is an adverse prognostic factor in squamous cell carcinoma of the head and neck (SCCHN) and promotes SCCHN cell proliferation and invasion. However, its mechanism remains unclear. Recent studies have indicated that MTDH is a cancer-metastasis-associated molecule that participates in the process of angiogenesis. Therefore, the study is aimed to investigate that whether vascular endothelial growth factor (VEGF), as one of the most potent proangiogenic cytokines, is regulated by MTDH and the role of the phosphatidylinositide 3-kinases/Protein Kinase B ...
Source: Medicine - February 1, 2015 Category: Internal Medicine Tags: Article: Clinical Trial/Experimental Study Source Type: research

Pd41-07 prognostic significance of lympho-vascular invasion in patients with squamous cell carcinoma in comparison to urothelial carcinoma of the bladder
Lympho-vascular invasion (LVI) has been shown to be an independent predictor of oncological outcomes in patients with urothelial carcinoma of the bladder (UCB) but its prognostic significance has not been studied in squamous cell carcinoma (SCC) due to the relative rarity of the disease. Herein, we compare the prognostic significance of LVI between SCC and UCB.
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Kyle Spradling, Hassan Abol-Enein, Ahmed Mosbah, Zhamshid Okhunov, Jaime Landman, Ahmed Shokeir, Mohamed Ghoneim, Ramy Youssef Tags: Bladder Cancer: Staging Source Type: research

Vascular Endothelial Growth Factor Receptor Isoforms: Are They Present in Oral Squamous Cell Carcinoma?
This study was conducted to investigate VEGF-R expression levels in OSCC samples and to identify any clinical relevance.
Source: Journal of Oral and Maxillofacial Surgery - April 14, 2015 Category: ENT & OMF Authors: Alix Pianka, Thomas Knösel, Florian Andreas Probst, Markus Troeltzsch, Timothy Woodlock, Sven Otto, Michael Ehrenfeld, Matthias Troeltzsch Tags: Pathology Source Type: research

Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinomas
Conclusion The OSCC tissue VEGF mRNA level can be used to predict the progression and prognosis of OSCCs in Taiwan.
Source: Journal of the Formosan Medical Association - June 8, 2015 Category: Journals (General) Source Type: research

Oral Squamous Cell Carcinoma and Vascular Endothelial Growth Factor Expression
To evaluate vascular endothelial growth factor (VEGF) expression in 42 samples of oral squamous cell carcinoma (OSCC) using immunohistochemistry (IHC), correlating that expression with the clinical staging of the OSCC (I, II, III, or IV) and its histological grade (World Health Organization classification).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 11, 2015 Category: ENT & OMF Authors: PATRICIA ROCCON BIANCHI MOLINI, ANDRESA BORGES SOARES, MARCELA SOL, PRISCILA MARINHO DE ABREU, MARIA CARMEN DOS SANTOS, SÔNIA ALVES GOUVEA, SANDRA VENTURIN VON ZEIDLER Source Type: research

Carotid Reconstruction With Bovine Carotid Heterograft After En Bloc Resection of Squamous Cell Carcinoma With Direct Internal Carotid Invasion
We report a novel use of the Artegraft (North Brunswick, NJ) bovine heterograft for carotid reconstruction after resection of a neck squamous cell carcinoma.
Source: Journal of Vascular Surgery - August 22, 2015 Category: Surgery Authors: Eric B. Trestman, Pablo De Los Santos, Evan Garfein, Thomas Ow, Evan C. Lipsitz, Saadat Shariff Tags: Abstract from the 2015 Eastern Vascular Society Annual Meeting Source Type: research

Randomized Trial Comparing Radiologic Pigtail Gastrostomy and Peroral Image-Guided Gastrostomy: Intra- and Postprocedural Pain, Radiation Exposure, Complications, and Quality of Life
Conclusions Despite the differences in insertion technique and tube caliber, the measured outcomes of POG and PG are comparable.
Source: Journal of Vascular and Interventional Radiology - August 25, 2015 Category: Radiology Source Type: research

Expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in Chinese patients with esophageal squamous cell carcinoma
Conclusion: High expression of COX-2, EGFR, and VEGF is an unfavorable prognostic factor in ESCC, and could be used as a poor prognosis indicator for the ESCC patients. Targeting therapy to these three targets should be considered to the combined treatment in ESCC.
Source: Journal of Cancer Research and Therapeutics - August 31, 2015 Category: Cancer & Oncology Authors: Yong CuiChang DongBing-Qun WuXin-Chun DuanGuan ShiMin GongTian-You Wang Source Type: research

Vascular endothelial growth factor C (VEGF-C) expression predicts metastasis in tongue cancer
Conclusions The local control rate of tongue SCC in the early stages has significantly improved as a result of development of surgical techniques. On the other hand, we believe that tumor depth of invasion (≥4 mm), POI, and VEGF-C expression all need to be considered in the preoperative and postoperative planning stages for tongue cancer treatment.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - September 5, 2015 Category: ENT & OMF Source Type: research

Correlation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) expressions with clinico-pathological features of oral squamous cell carcinoma (OSCC)
Publication date: Available online 14 October 2015 Source:Tanta Dental Journal Author(s): Heba El-Sayed Mohammed Youssef, Nahed Emad Eldeen Abo-Azma, Eman Mohie Eldeen Megahed Oral squamous cell carcinoma (OSCC) is a characteristic aggressiv e tumor representing a significant public health threat all over the world. Up to 50–60% of solid tumors may exhibit hypoxic tissue areas that are heterogeneously distributed within the tumor stroma. Hypoxia inducible factor-1α (HIF-1α) is a central regulator in the adaptive cellular response to hypoxia; however its role is still uncovered. Vascular endothelial growth factor ...
Source: Tanta Dental Journal - October 23, 2015 Category: Dentistry Source Type: research

Malignant melanoma clinically masquerading vascular tumor: A diagnostic dilemma
Samiksha Pradhan, Karan Sancheti, Indrashis Podder, Ramesh Chandra GharamiIndian Journal of Dermatology 2015 60(6):606-608Malignant melanoma is an invasive neoplasm of the skin, whose incidence is reported to be rising among Indians. We hereby present a unique case of unilateral, multiple, asymptomatic, pigmented, nodular lesions over the lower limb; resembling vascular tumor, revealing itself as malignant melanoma only on histopathology. To the best of our knowledge, such a unique presentation of malignant melanoma has not yet been reported from the Indian subcontinent.
Source: Indian Journal of Dermatology - November 5, 2015 Category: Dermatology Authors: Samiksha PradhanKaran SanchetiIndrashis PodderRamesh Chandra Gharami Source Type: research

Significance of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in the Progression of Cutaneous Melanoma
Conclusions. Our findings show the significance of VEGF-C in tumor cells in the induction of intratumoral and peritumoral lymphangiogenesis. This study suggests that both VEGF-C and VEGF-D in tumor cells promote lymph node metastasis, and that the immunohistochemical analysis of expression can be a useful tool for predicting clinical behavior of cutaneous melanoma.
Source: International Journal of Surgical Pathology - November 9, 2015 Category: Pathology Authors: Spiric, Z., Eri, Z., Eric, M. Tags: Original Articles Source Type: research

Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas.
Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas. Acupunct Electrother Res. 2006;31(1-2):61-125 Authors: Omura Y Abstract High incidences of Small Cell Carcinoma & Adenocarcinoma of the lung, Astrocytoma & Glioblastoma Multiforme of the brain and Mesothelioma of ...
Source: Acupuncture and Electro-Therapeutics Research - November 30, 2015 Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research