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Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells.
This study aimed to demonstrate that TSA has potent anti-angiogenic activity in vitro and ex vivo. Additionally, we evaluated the role of TSA in the VEGF/VEGFR2 pathway. Through a series of in vitro experiments, we found that TSA has a negative effect on cell proliferation, migration and tube formation of human umbilical vascular endothelial cells. We further showed that TSA can inhibit angiogenesis using chorioallantoic membrane (CAM) and rat aortic ring assays. Furthermore, western blotting demonstrated that TSA effectively suppressed the expression of VEGR2 and CD146. These results suggest that TSA inhibits angiogene...
Source: Oncology Reports - November 16, 2014 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI Abstract Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research

Google Search Trends and Skin Cancer
Whether there is an association between population inquisitiveness in skin cancer and melanoma incidence, mortality, and the mortality to incidence ratio is unknown. Google Trends quantifies interest in topics at the population level by analyzing all search queries for a specific term, thus serving as an increasingly useful research tool. Search volume indexes (SVIs) are normalized values based on total searches during a specified period per selected region. We decided to use this innovative tool to evaluate whether population inquisitiveness on melanoma and skin cancer was correlated with a lower incidence, mortality, and...
Source: JAMA Dermatology - June 10, 2015 Category: Dermatology Source Type: research

Abstract B52: Mechanisms of rapalogues' anti-vascular effects in head and neck cancer
Conclusions: Our preliminary results suggest that anti-vascular properties of rapamycin are primarily a result of drug's direct effects on endothelial cells, and not cross-talk mediated, effects. Soluble IL-6 can be a potential biomarker of response to mTOR inhibitor therapy.Citation Format: Oleksandr Ekshyyan, Hesam Akbarian-Tefaghi, Adam Green, Xiaohua Rong, Jonathan Steven Alexander, Cherie-Ann O. Nathan. Mechanisms of rapalogues' anti-vascular effects in head and neck cancer. [abstract]. In: Proceedings of the AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; Sep 14-17, 2014; Philadelphia, PA. Philade...
Source: Molecular Cancer Therapeutics - July 6, 2015 Category: Cancer & Oncology Authors: Ekshyyan, O., Akbarian-Tefaghi, H., Green, A., Rong, X., Alexander, J. S., Nathan, C.-A. O. Tags: Other Topics: Poster Presentations - Proffered Abstracts Source Type: research

The search for cis-regulatory driver mutations in cancer genomes.
Authors: Poulos RC, Sloane MA, Hesson LB, Wong JW Abstract With the advent of high-throughput and relatively inexpensive whole-genome sequencing technology, the focus of cancer research has begun to shift toward analyses of somatic mutations in non-coding cis-regulatory elements of the cancer genome. Cis-regulatory elements play an important role in gene regulation, with mutations in these elements potentially resulting in changes to the expression of linked genes. The recent discoveries of recurrent TERT promoter mutations in melanoma, and recurrent mutations that create a super-enhancer regulating TAL1 expression...
Source: Oncotarget - September 13, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma
This study evaluated the associations between lymphatic and vascular invasion of oral cavity squamous cell carcinoma (OSCC) and clinicopathological manifestations, as well as their impact on patient outcomes after treatment. In total, 571 patients with primary OSCC who underwent surgery with or without adjuvant therapy were enrolled. Lymphatic and vascular invasion were found in 28 (5%) and 16 (3%) patients, respectively. Significant associations were found between lymphatic and vascular invasion and overall stage (P 
Source: Medicine - October 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Tumor cell vascular mimicry: Novel targeting opportunity in melanoma
Publication date: Available online 22 January 2016 Source:Pharmacology & Therapeutics Author(s): Mary J.C. Hendrix, Elisabeth A. Seftor <e>m-hendrix@northwestern.edu, Richard E.B. Seftor, Jun-Tzu Chao, Du-Shieng Chien, Yi-Wen Chu In 1999, the American Journal of Pathology published an article, entitled “Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry” by Maniotis and colleagues, which ignited a spirited debate for several years and earned the journal’s distinction of a “citation classic” (Maniotis et al., 1999). Tumor cell vasculogenic mi...
Source: Pharmacology and Therapeutics - January 25, 2016 Category: Drugs & Pharmacology Source Type: research

Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding.
In this study we generated an anti-VEGFR-1 mAb (D16F7) by immunizing BALB/C mice with a peptide that we had previously reported to inhibit angiogenesis and endothelial cell migration induced by PlGF. D16F7 did not affect binding of VEGF-A or PlGF to VEGFR-1, thus allowing sVEGFR-1 to act as decoy receptor for these growth factors, but it hampered receptor homodimerization and activation. D16F7 inhibited both the chemotactic response of human endothelial, myelomonocytic and melanoma cells to VEGFR-1 ligands and vasculogenic mimicry by tumor cells. Moreover, D16F7 exerted in vivo antiangiogenic effects in a matrigel plug ass...
Source: Oncotarget - September 23, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Vascular-Associated Muc4/Vwf Co-Localization in Human Conjunctival Malignant Melanoma Specimens-Tumor Metastasis by Migration?
CONCLUSIONS: MUC4 was detected around vWf/KI67-positive CMM stromal vascular tissue, but not around healthy conjunctival stroma vessels. Therefore, we assume that MUC4 might play a role in tumor cell migration toward vessels inducing metastasis. PMID: 28622066 [PubMed - as supplied by publisher]
Source: Current Eye Research - June 16, 2017 Category: Opthalmology Authors: Kakkassery V, Winterhalter S, Nick AC, Joachim SC, Joussen AM, Kociok N Tags: Curr Eye Res Source Type: research

Diagnostic Significance of Measuring Vascular Endothelial Growth Factor for the Differentiation between Malignant and Tuberculous Pleural Effusion.
In conclusion, high VEGF levels in pleural effusion are suggestive of malignant pleural effusion. PMID: 28626164 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - June 20, 2017 Category: Research Authors: Kim HR, Kim BR, Park RK, Yoon KH, Jeong ET, Hwang KE Tags: Tohoku J Exp Med Source Type: research

Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects.
Abstract A series of 14 analogs of the curcuminoid EF24, (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone, bearing fluorine or pentafluorothio substituents, were prepared and tested for antiproliferative, vascular-disruptive, and antiangiogenic activity, as well as for their influence on other cancer-relevant targets. They proved antiproliferative against eight cancer cell lines with IC50 values in the low single-digit micromolar to triple-digit nanomolar range. Like EF24, the hexafluoro 3c and 3d and bis(pentafluorothio) 4f derivatives arrested HT-29 colon carcinoma cells in G2/M phase of the cell cycle,...
Source: Bioorganic and Medicinal Chemistry - July 21, 2017 Category: Chemistry Authors: Schmitt F, Gold M, Begemann G, Andronache I, Biersack B, Schobert R Tags: Bioorg Med Chem Source Type: research

INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT AT 2-MONTH INTERVALS REDUCES FOVEAL AVASCULAR ZONE ENLARGEMENT AND VISION LOSS IN RADIATION MACULOPATHY: A Pilot Study
Purpose: To evaluate, in eyes with radiation maculopathy, the effect of 2-month-interval anti–vascular endothelial growth factor therapy on best-corrected visual acuity and foveal avascular zone (FAZ) enlargement using optical coherence tomography angiography. Methods: Consecutive treatment-naive patients with radiation maculopathy after proton beam irradiation for choroidal melanoma were retrospectively included. Clinical and optical coherence tomography angiography data at baseline and the 6-month visit were recorded. Two independent observers measured FAZ area manually on 3 × 3-mm optical coherence tomography an...
Source: RETINA - July 24, 2019 Category: Opthalmology Tags: Original Study Source Type: research

Hypoxia-inducible factor 1 α in combination with vascular endothelial growth factor could predict the prognosis of postoperative patients with oesophageal squamous cell cancer.
In conclusion, HIF-1a combined with VEGF could enable us to more accurately predict the prognosis of OSCC patients. PMID: 31556558 [PubMed - in process]
Source: Polish Journal of Pathology - September 27, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

The prevailing dermoscopic vascular pattern in melanoma is influenced by tumor thickness and pigmentation type.
Abstract In non-pigmented skin tumors the diagnosis is mainly based on the evaluation of the vascular morphology and vessels´ distribution dermoscopically [1-4]. However, up to date, no study formally correlated the prevailing vascular morphology with the thickness of melanoma according to Breslow and amount of pigmentation. PMID: 31605621 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - October 11, 2019 Category: Dermatology Authors: Deinlein T, Longo C, Schulter G, Pizzichetta MA, Zalaudek I Tags: Br J Dermatol Source Type: research

Congenital vascular lesions, could MAPK and PI3K inhibitors pave the way to new therapies?
Purpose of review Superficial vascular anomalies are a heterogeneous group of malformative and tumoral lesions, developed from various types of abnormal lymphatic and/or blood vessels. They are mostly benign but their clinical evolution can lead to dramatic cosmetic concern, functional impairment and even life-threatening conditions. Until recently, treatments relied on invasive procedures such as embotherapy/sclerotherapy and/or surgery. Recent molecular findings pave the way of new medical therapies. Recent findings Two main signaling pathways PI3K-AKT-mTOR and RAS-MAPK-ERK are now identified to encounter for ...
Source: Current Opinion in Oncology - February 25, 2021 Category: Cancer & Oncology Tags: MELANOMA AND OTHER SKIN NEOPLASMS: Edited by Céleste Lebbé and Nicolas Dumaz Source Type: research