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Total 2502 results found since Jan 2013.

Mixed Primary Hepatocellular Carcinoma and Hepatic Neuroendocrine Carcinoma: Case Report and Literature Review
Medicina (Kaunas). 2023 Feb 20;59(2):418. doi: 10.3390/medicina59020418.ABSTRACTMixed hepatocellular carcinoma with neuroendocrine carcinoma (HCC-NEC) is extremely rare, comprising about 0.46% of primary hepatic tumors. A 63-year-old man who was a chronic alcoholic presented with a nine-centimeter-sized hepatic mass. His serum alpha-fetoprotein and protein induced by vitamin K antagonist-II levels were 22,815 ng/mL and 183 mAU/mL, respectively. The patient underwent a right hemihepatectomy, including the middle hepatic vein. The tumor consisted of poorly differentiated HCC (20%) and large- and small-cell-type NEC (80%) com...
Source: Medicina (Kaunas) - February 25, 2023 Category: Universities & Medical Training Authors: Woo Young Shin Keon Young Lee Kyeong Deok Kim Source Type: research

Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain
Conclusion: This is the first report on ellagic acid ’s ameliorative effect in rats’ CCI-induced neuropathic pain. This effect can be attributed to its anti-oxidative and anti-inflammatory, thus making it potentially useful as an adjuvant to conventional treatment.
Source: Metabolic Brain Disease - February 22, 2023 Category: Neurology Source Type: research

What the Ozempic Obsession Misses About Food and Health
In a country obsessed with thinness, Ozempic is the latest in a long line of weight loss miracles. After its approval in 2017 to help manage blood sugar in Type 2 diabetics, news quickly spread that it also caused weight loss; fast-forward to 2023 and #Ozempic has over 300 million views on TikTok. Celebrities and influencers quickly jumped on the Ozempic bandwagon, and by now the drug has achieved mainstream appeal. So much so that Type 2 diabetics are struggling to access it due to its intense demand. According to Komodo Health, over 5 million prescriptions were written for Ozempic or the similar drug Mounjaro in 2022. [t...
Source: TIME: Health - February 21, 2023 Category: Consumer Health News Authors: Tess Bredesen Tags: Uncategorized freelance health Source Type: news

Schwann cell-derived CXCL2 contributes to cancer pain by modulating macrophage infiltration in a mouse breast cancer model
Brain Behav Immun. 2023 Feb 6:S0889-1591(23)00029-6. doi: 10.1016/j.bbi.2023.02.004. Online ahead of print.ABSTRACTPain is one of the most severe complications affecting the quality of life of cancer patients. Although substantial progress has been made in the diagnosis and treatment of cancer, the neurobiological mechanism of cancer pain is still unclear. In the present study, we identified the critical role of CXC chemokine 2 (CXCL2), released by Schwann cells after being activated by cancer cells, in maintaining cancer-induced macrophage infiltration and the resulting mechanical hypersensitivity and persistent spontaneo...
Source: Brain, Behavior, and Immunity - February 8, 2023 Category: Neurology Authors: Yonghui Zhang Rui Sang Jingyin Bao Zhihao Jiang Danni Qian Yi Zhou Wenfeng Su Jinhuan Wei Long Zhao Zhongya Wei Yayu Zhao Minxin Shi Gang Chen Source Type: research

Iris metastasis as resistance mechanism to atezolizumab, carboplatin, and etoposide but responds to additional irinotecan and anlotinib in a small cell lung cancer patient
Small cell lung cancer patients presenting with metastasis of the iris are rare. Here, we report an extensive stage small cell lung cancer patient who presented with iris metastasis in the right eye and metastasis in the left adrenal gland as disease progression to first-line chemotherapy plus atezolizumab. The patient was subsequently treated with irinotecan combined with anlotinib and atezolizumab, and a dramatic response was obtained not only for left adrenal gland metastasis but for iris metastasis. AbstractSmall cell lung cancer (SCLC) is an aggressive malignancy associated with poor prognosis. Metastasis to sites out...
Source: Thoracic Cancer - February 7, 2023 Category: Cancer & Oncology Authors: Zhe Huang, Yongchang Zhang Tags: CASE REPORT Source Type: research

Characterization and Treatment of Spinal Tumors
Intensive Care Res. 2022 Dec;2(3-4):76-95. doi: 10.1007/s44231-022-00014-3. Epub 2022 Sep 8.ABSTRACTThe prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be divided into primary and metastatic tumors with the latter being the most common presentation. Primary tumors are subdivided based on their location on the spinal column and in the spinal cord into intramedullary, intradural extramedullary, and primary bone tumors. Back pain is a common presentation in spine cancer patients; however, other radicular pain may be present. Magnetic...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Efosa Amadasu Eric Panther Brandon Lucke-Wold Source Type: research

Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we evaluated whether chronic pain stimuli could directly affect...
Source: Molecular Brain - February 3, 2023 Category: Neuroscience Authors: Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Takatsune Shimizu, Naoko Kuzumaki and Minoru Narita Tags: Research Source Type: research

Ultrasound is Ultra-Cool
This study is also a major step forward for the exciting possibility of combining focused ultrasound with targeted delivery of medications or antibodies that normally have limited capability to cross the blood brain barrier from the blood to the brain.”  Similarly, researchers at Yonsei University College of Medicine (South Korea) found that focused ultrasound improved the delivery of Alzheimer’s drugs by over eight times.  “While there is no complete cure for dementia, we hope that open BBB [blood brain barrier] surgery using FUS surgery can help give hope to dementia patients,” the lead researcher said. ...
Source: The Health Care Blog - January 25, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech 3D printing ChatGPT DSP Kim Bellard Ultrasound Source Type: blogs

Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How My Father ’ s Brain Helped Develop More Effective Treatment For Alzheimer ’ s
My father is at the Selkoe Laboratory at Brigham and Women’s Hospital. And he is at work. That may seem improbable given that, in March 2022, my father died of Alzheimer’s disease. But, since he died, my father has helped pioneer the validation of effective treatments that weren’t available for him; research conducted on his brain tissue is helping scientists understand how to (hopefully) improve upon the recently FDA-approved lecanemab and develop even more effective treatment for Alzheimer’s disease. Over the years my mother, sisters, and I cared for my dad, we focused on navigating immediate obst...
Source: TIME: Health - January 14, 2023 Category: Consumer Health News Authors: Rebecca Leventhal Tags: Uncategorized Evergreen freelance health Health Care Source Type: news

Cannabinoids as a Potential Alternative to Opioids in the Management of Various Pain Subtypes: Benefits, Limitations, and Risks
CONCLUSION: Cannabinoids may be effective in specific subtypes of pain, but current evidence and guidelines do not yet support its use as the first-line treatment for any type of acute or chronic pain. Rather, it may be considered a good adjunct or alternative for patients who have failed more typical or conservative measures. Additional studies are needed with standardized forms of cannabinoids, route of delivery, and dosing for greater-powered analysis. Providers must weigh the individualized patient risks, benefits, and concurrent medication list in order to determine whether cannabinoids are appropriate for a patient's...
Source: Cancer Control - January 13, 2023 Category: Cancer & Oncology Authors: Samuel P Ang Shawn Sidharthan Wilson Lai Nasir Hussain Kiran V Patel Amitabh Gulati Onyeaka Henry Alan D Kaye Vwaire Orhurhu Source Type: research