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Total 15396 results found since Jan 2013.

DNA and histone modifications as potent diagnostic and therapeutic targets to advance non-small cell lung cancer management from the perspective of 3P medicine
This article aims to review the roles DNA and his tone modifications play in tumorigenesis, early detection and diagnosis, and advancements and therapies of NSCLC, and also explore the connection between DNA and histone modifications and PPPM, which may provide an important contribution to improve the prognosis of NSCLC. We found that the success o f targeting DNA and histone modifications is limited in the clinic, and how to combine the therapies to improve patient outcomes is necessary in further studies, especially for predictive diagnostics, targeted prevention, and personalization of medical services in the 3P medicin...
Source: EPMA Journal - November 2, 2022 Category: International Medicine & Public Health Source Type: research

Personalized medicine in screening for malignant disease: a review of methods and applications.
Abstract Personalized medicine (PM) is currently a hot topic in the professional world. It is often called the medicine of the future and has already achieved resounding success in the area of targeted therapy. Nevertheless, integration of the concepts of PM into routine clinical practice is slow. This review is intended to give an overview of current and potential applications of PM in oncology. PM could soon play a decisive role, especially in screening. The relevance of PM in screening was examined in the case of four common cancers (colorectal cancer, lung cancer, breast cancer, and prostate cancer). A literat...
Source: Biomarker Insights - May 23, 2013 Category: Journals (General) Authors: Schmalfuss F, Kolominsky-Rabas PL Tags: Biomark Insights Source Type: research

Integrated Chinese-western therapy versus western therapy alone on survival rate in patients with non-small-cell lung cancer at middle-late stage.
CONCLUSION: Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone. PMID: 24187861 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - August 1, 2013 Category: Complementary Medicine Authors: Lin G, Li Y, Chen S, Jiang H Tags: J Tradit Chin Med Source Type: research

Comparison of 4-Dimensional Computed Tomography Ventilation With Nuclear Medicine Ventilation-Perfusion Imaging: A Clinical Validation Study
Conclusions: The current work compared 4DCT with VQ-based ventilation using clinically relevant global metrics and radiologist observations. We found good agreement between the radiologist's assessment of the 4DCT and VQ-ventilation images as well as the percent ventilation in each lung. The agreement lessened when the data were analyzed on a regional level. Our study presents an important step for the integration of 4DCT-ventilation into thoracic clinical practice.
Source: International Journal of Radiation Oncology * Biology * Physics - April 10, 2014 Category: Radiology Authors: Yevgeniy Vinogradskiy, Phillip J. Koo, Richard Castillo, Edward Castillo, Thomas Guerrero, Laurie E. Gaspar, Moyed Miften, Brian D. Kavanagh Tags: Physics Contributions Source Type: research

Personalised Cancer Medicine
Abstract The evolving field of personalised medicine is playing an increasingly important role in cancer prevention, diagnosis, prognosis and therapeutics. Its importance in clinical management is demonstrated by the recent introduction into routine clinical practice of various individualised, molecularly‐targeted therapies with increased efficacy and/or reduced toxicity. The identification of cancer predisposition genes, such as the BRCA genes in breast cancer, permits screening programmes to identify patients ‘at‐risk' of developing cancer and helps them make decisions on individual risk‐modification behaviours. ...
Source: International Journal of Cancer - May 2, 2014 Category: Cancer & Oncology Authors: Sarah E Jackson, John D Chester Tags: Mini Review Source Type: research

An official american thoracic society/american college of chest physicians policy statement: the choosing wisely top five list in adult pulmonary medicine.
Abstract The American Board of Internal Medicine Foundation's Choosing Wisely campaign aims to curb health-care costs and improve patient care by soliciting lists from medical societies of the top five tests or treatments in their specialty that are used too frequently and inappropriately. The American Thoracic Society (ATS) and American College of Chest Physicians created a joint task force, which produced a top five list for adult pulmonary medicine. Our top five recommendations, which were approved by the executive committees of the ATS and American College of Chest Physicians and published by Choosing Wisely i...
Source: Chest - June 1, 2014 Category: Respiratory Medicine Authors: Wiener RS, Ouellette DR, Diamond E, Fan VS, Maurer JR, Mularski RA, Peters JI, Halpern SD Tags: Chest Source Type: research

Detection of aberrant methylation of tumor suppressor genes in plasma from cancer patients
Conclusion Our results indicate that the frequency of methylation of cancer-related genes is dependent on the type of cancer and patient. Therefore, DNA methylation of cancer-related genes has a high potential as a biomarker for personalized medicine.
Source: Personalized Medicine Universe - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Current practice in and considerations for personalized medicine in lung cancer: From the patient's molecular biology to patient values and preferences
With population aging around the world and a greater incidence of cancers and complex illnesses that emerge in mid- and late-life, societal debates are increasingly focused on rapidly rising healthcare costs and the economic burden such costs bring to individuals and their health systems [1]. Personalized, or ‘precision’, approaches to medicine are widely envisioned as the future of medicine, with an individual patient's genetics at the center [2–4]. In its predictive capacity, personalized medicine has been portrayed by many as a panacea for preventing and reducing the incidence of certain types of disease and, in i...
Source: Maturitas - April 23, 2015 Category: Primary Care Authors: Pricivel M. Carrera, Meghann Ormond Source Type: research

Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy
Lung diseases cause an enormous socioeconomic burden. Four of them are among the ten most important causes of deaths worldwide: Pneumonia has the highest death toll of all infectious diseases, lung cancer kills the most people of all malignant proliferative disorders, chronic obstructive pulmonary disease (COPD) ranks third in mortality among the chronic noncommunicable diseases, and tuberculosis is still one of the most important chronic infectious diseases. Despite all efforts, for example, by the World Health Organization and clinical and experimental researchers, these diseases are still highly prevalent and harmful. T...
Source: Springer protocols feed by Bioinformatics - December 21, 2015 Category: Bioinformatics Source Type: news

Molecular Imaging and Precision Medicine in Lung Cancer
Precision medicine allows tailoring of preventive or therapeutic interventions to avoid the expense and toxicity of futile treatment given to those who will not respond. Lung cancer is a heterogeneous disease functionally and morphologically. PET is a sensitive molecular imaging technique with a major role in the precision medicine algorithm of patients with lung cancer. It contributes to the precision medicine of lung neoplasia by interrogating tumor heterogeneity throughout the body. It provides anatomofunctional insight during diagnosis, staging, and restaging of the disease. It is a biomarker of tumoral heterogeneity t...
Source: PET Clinics - September 9, 2016 Category: Radiology Authors: Katherine A. Zukotynski, Victor H. Gerbaudo Source Type: research

Oral Chinese herbal medicine as maintenance treatment after chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.
CONCLUSIONS: For patients who show non-progression-including stable disease, partial response, or complete response-after first-line chemotherapy, including those with poor quality of life, oral Chinese herbal medicine can be considered an efficient and safe maintenance therapy strategy. PMID: 28874897 [PubMed]
Source: Current Oncology - September 7, 2017 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Enhanced anticancer effects of Scutellaria barbata D. Don in combination with traditional Chinese medicine components on non-small cell lung cancer cells
Conclusion LJSJF exerts more pronounced cytotoxic effects against NSCLC cells than SB does by synergistically regulating the underlining molecular mechanisms including EGFR and/or p53 signaling pathways. Graphical abstract
Source: Journal of Ethnopharmacology - February 23, 2018 Category: Drugs & Pharmacology Source Type: research

Treatment of Advanced Non-small-Cell Lung Cancer with Qi-Nourishing Essence-Replenishing Chinese Herbal Medicine Combined with Chemotherapy.
Conclusion: Qi-nourishing essence-replenishing Chinese herbal medicine combined with chemotherapy improves survival of advanced NSCLC patients with essence and qi deficiency. PMID: 29618954 [PubMed]
Source: Biological Procedures Online - April 7, 2018 Category: Molecular Biology Authors: Gong Y, Xu Z, Jin C, Deng H, Wang Z, Zhou W, Zhang M, Zhao X, Wang L Tags: Biol Proced Online Source Type: research

Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway. PMID: 29632297 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Maekmoondong-tang in treatment of postoperative cough in patients with lung cancer: Study protocol for a randomized, double-blind, placebo-controlled, multicenter trial
This study is a randomized, double-blind, placebo-controlled, multicenter trial of Maekmoondong-tang. A total of 96 participants will be enrolled and allocated to 2 parallel groups: the Maekmoondong-tang group and the placebo group from 5 university hospitals. The participants will be administered either Maekmoondong-tang or a placebo 3 times a day for 4 weeks. The primary outcome measurement is the change in the Leicester Cough Questionnaire (LCQ) score. The secondary outcome measurements are the changes in the cough visual analog scale and Yin Deficiency Scale. The participants will visit 4 times in total for 4 weeks of ...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research