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Total 15396 results found since Jan 2013.

Clinical decisions by the molecular tumor board on comprehensive genomic profiling tests in Japan: A retrospective observational study
ConclusionThe results of this study may be used to simplify treatment recommendations from the CGP reports and help select patients for testing, thereby increasing the accuracy of personalized medicine.
Source: Cancer Medicine - October 17, 2022 Category: Cancer & Oncology Authors: Hidekazu Shirota, Keigo Komine, Masanobu Takahashi, Shin Takahashi, Eisaku Miyauchi, Hidetaka Niizuma, Hiroshi Tada, Muneaki Shimada, Tetsuya Niihori, Yoko Aoki, Ikuko Sugiyama, Maako Kawamura, Jun Yasuda, Shuhei Suzuki, Takeshi Iwaya, Moto Tags: RESEARCH ARTICLE Source Type: research

Molecules, Vol. 28, Pages 1939: A Meroterpenoid from Tibetan Medicine Induces Lung Cancer Cells Apoptosis through ROS-Mediated Inactivation of the AKT Pathway
Gao Jie Yuan As a traditional Tibetan medicine in China, Meconopsis grandis Prain has been used to treat a variety of illnesses by local people for thousands of years. However, the active ingredients contained in Meconopsis grandis Prain and its pharmacodynamic mechanisms have scarcely been reported. We isolated a meroterpenoid named D1399 from Meconopsis grandis Prain endophytic fungi with strong antitumor activity. The structure analysis showed that D1399 is an alkaloid containing a 13-membered macrocyclic structure. The IC50 of D1399 for human lung cancer cells’ viability ranged from 0.88 to 2.45 &a...
Source: Molecules - February 17, 2023 Category: Chemistry Authors: Yi Huang Yun Huang Ge Zhu Bingzhi Zhang Yujia Zhu Bin Chen Xiaoxia Gao Jie Yuan Tags: Article Source Type: research

Bibliometric and visual analysis in the field of traditional Chinese medicine in cancer from 2002 to 2022
Conclusion: Traditional Chinese medicine as an anti-cancer drug has received increasing attention from researchers worldwide, and it is expected to be a hotspot for developing new anti-cancer drugs in the future. Our study provides a comprehensive analysis of the current status and hotspots of TCM cancer research, which could serve as a valuable reference for future studies.
Source: Frontiers in Pharmacology - July 4, 2023 Category: Drugs & Pharmacology Source Type: research

A Cross-Talk about Radioresistance in Lung Cancer-How to Improve Radiosensitivity According to Chinese Medicine and Medicaments That Commonly Occur in Pharmacies
Int J Mol Sci. 2023 Jul 7;24(13):11206. doi: 10.3390/ijms241311206.ABSTRACTLung cancer is one of the most common cancers in the population and is characterized by non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological treatment. Due to the difficult placement of the tumor, one of the main methods of lung cancer treatment is radiotherapy, which damages the DNA of cancer cells, inducing their apoptosis. However, resistance to ionizing radiation may develop during radiotherapy cycles, leading to an increase in the number of DNA points of control that protect cells from apoptosis. Cancer ste...
Source: Cancer Control - July 14, 2023 Category: Cancer & Oncology Authors: Paulina Nowak Iwona Bil-Lula Mariola Śliwińska-Mossoń Source Type: research

Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene
CONCLUSION: These findings suggest that the sodium iodide symporter can serve as a reliable nuclear medicine reporter gene for non-invasively imaging the biological activity of mast cells in mice with lung tumors. Visualizing mast cells in the tumor microenvironment via a nuclear medicine reporter gene would provide valuable insights into their biological functions.PMID:37562258 | DOI:10.1016/j.neo.2023.100925
Source: Neoplasia - August 10, 2023 Category: Cancer & Oncology Authors: Seul-Gi Oh Jun Young Choi Jae-Eon Lee SoYeon Jeon Bo-Ra Lee Kwang Hee Son Sang Bong Lee Beum-Soo An Dae Youn Hwang Seong-Jang Kim Ki-Tae Ha Jaetae Lee Yong Hyun Jeon Source Type: research

Lung cancer genotype-based therapy and predictive biomarkers: present and future.
Conclusions.-First-generation tyrosine kinase inhibitors have produced clinical response in a limited number of non-small cell lung cancers demonstrated to have activating mutations of epidermal growth factor receptor or anaplastic lymphoma kinase rearrangements with fusion partners. Patients treated with first-generation tyrosine kinase inhibitors develop acquired resistance to their therapy. Ongoing investigations of second-generation tyrosine kinase inhibitors and new druggable targets as well as the development of next-generation genotyping and new antibodies for immunohistochemistry promise to significantly expand the...
Source: Archives of Pathology and Laboratory Medicine - December 1, 2012 Category: Laboratory Medicine Authors: Cagle PT, Allen TC Tags: Arch Pathol Lab Med Source Type: research

Applied research on serum protein fingerprints for prediction of Qi deficiency syndrome and phlegm and blood stasis in patients with non-small cell lung cancer.
CONCLUSION: SELDI-TOF-MS techniques, combined with a decision tree model, can help identify serum proteomic biomarkers related to Qi deficiency syndrome and phlegm and blood stasis in lung cancer patients; and the predictive model can be used to discriminate between Chinese medicine diagnostic models of disease. PMID: 23297554 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - September 1, 2012 Category: Complementary Medicine Authors: Liu Z, Yu Z, Ouyang X, Du J, Lan X, Zhao M Tags: J Tradit Chin Med Source Type: research

Lung cancer epigenetics: emerging biomarkers
Biomarkers in Medicine , February 2013, Vol. 7, No. 1, Pages 49-58.
Source: Future Medicine: Biomarkers in Medicine - February 6, 2013 Category: Internal Medicine Tags: article Source Type: research

An economic model to value companion diagnostics in non-small-cell lung cancer
Personalized Medicine , March 2013, Vol. 10, No. 2, Pages 139-147.
Source: Future Medicine: Personalized Medicine - February 27, 2013 Category: Genetics & Stem Cells Tags: article Source Type: research

Research Highlights: Highlights from the latest articles in translating genomics to clinical practice in lung cancer
Personalized Medicine , June 2013, Vol. 10, No. 4, Pages 329-331.
Source: Future Medicine: Personalized Medicine - June 6, 2013 Category: Genetics & Stem Cells Tags: article Source Type: research

Is Personalized Medicine Too Pricey?Is Personalized Medicine Too Pricey?
Dr. David Kerr reports on a study that assessed the cost-effectiveness of testing lung cancer patients for targeted drug sensitivity markers, and what the results could mean for personalized medicine. Medscape Oncology
Source: Medscape Today Headlines - July 29, 2013 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Penn docs find successful strategy to expand patient participation in hard-to-enroll clinical trials
(University of Pennsylvania School of Medicine) Clinical trials are key to finding new cancer treatments, but with patient participation hovering around 5 percent, new strategies are needed to boost enrollment, particularly to study the rare cancers that have so few cases. One such strategy comes from a new abstract being presented Oct. 28 at the 15th World Conference on Lung Cancer from researchers at Perelman School of Medicine at the University of Pennsylvania studying mesothelioma.
Source: EurekAlert! - Medicine and Health - October 23, 2013 Category: Global & Universal Source Type: news

Diabetes drug metformin with chemo and radiation may improve outcomes in lung cancer patients
(University of Pennsylvania School of Medicine) Treating aggressive lung cancer with the diabetes drug metformin along with radiation and chemotherapy may slow tumor growth and recurrence, suggests new preliminary findings from researchers at the Perelman School of Medicine at the University of Pennsylvania being presented during an oral abstract session Oct. 28 at the 15th World Conference on Lung Cancer.
Source: EurekAlert! - Medicine and Health - October 23, 2013 Category: Global & Universal Source Type: news

Final recommendations on lung cancer screening
(American College of Physicians) Below is information about an article being published in Annals of Internal Medicine. The information is not intended to substitute for the full article as a source of information. Annals of Internal Medicine attribution is required for all coverage.
Source: EurekAlert! - Medicine and Health - December 30, 2013 Category: Global & Universal Source Type: news