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Application of Response Evaluation Criteria of Traditional Chinese Medicine for Solid Tumor in advanced non-small cell lung cancer
Conclusions REC-TCM-ST was used to evaluate the therapeutic effect of CM in the treatment of advanced NSCLC, which shows that its evaluation results can better reflect the advantages and disadvantages of CM, and the effectiveness of CM is more objective and comprehensive than RECIST, so REC-TCM-ST is worthy of further improvement and clinical expansion.
Source: Chinese Journal of Integrative Medicine - November 26, 2014 Category: Internal Medicine Source Type: research

From systems biology to P4 medicine: applications in respiratory medicine
Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, "omics" data and bioinformatic computing power. It paves the way forward towards "P4 medicine" (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2...
Source: European Respiratory Review - February 7, 2018 Category: Respiratory Medicine Authors: Noell, G., Faner, R., Agusti, A. Tags: Respiratory clinical practice Personalised Medicine in Respiratory Diseases Source Type: research

Pattern identification of lung cancer patients based on body constitution questionnaires (BCQ) and glycoproteomics for precision medicine
This study intends to diagnose pattern identification of patients in TKM with BCQ assessment and proteomics approach. The identification of the glycoproteins in each group will lead to the scientific foundation of personalized medicine in TKM according to patients’ pattern identification for lung cancer therapy. We intend to (1) diagnose the pattern identification types of lung cancer patients with BCQ under the framework of TKM; (2) evaluate BCQ assessment with glycoproteomics approach for precision medicine. Trial registration: ClinicalTrials.gov NCT03384680. Registered 27 December 2017. Retrospectively registered.
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine.
Conclusion: The FACT-G total score and PWB score as HRQoL measurements were significant prognostic factors for survival in advanced NSCLC patients treated with Korean medicine. This finding implies that the FACT-G can be used in clinical practice as a predictor of survival in patients with advanced NSCLC. PMID: 32454853 [PubMed - as supplied by publisher]
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of gefitinib plus Chinese herbal medicine (CHM) in patients with advanced non-small-cell lung cancer: A retrospective case-control study.
CONCLUSIONS: This case-control analysis suggested that treatment with gefitinib plus CHM prolonged PFS and MST compared with gefitinib in patients with NSCLC, and it is worthy of further study. PMID: 25453521 [PubMed - in process]
Source: Complementary Therapies in Medicine - December 1, 2014 Category: Complementary Medicine Authors: Yang XB, Wu WY, Long SQ, Deng H, Pan ZQ Tags: Complement Ther Med Source Type: research

Nuclear medicine scan could identify who might benefit from aromatase inhibitor treatment
(Society of Nuclear Medicine) A new, noninvasive nuclear medicine test can be used to determine whether aromatase inhibitor treatment will be effective for specific cancer patients, according to a recent study reported in The Journal of Nuclear Medicine. The research shows that a PET scan with the ligand C-11-vorozole reliably detects aromatase in all body organs - demonstrating the value of its future use to pre-determine the effectiveness of the treatment for breast, ovarian, endometrial and lung cancer patients.
Source: EurekAlert! - Medicine and Health - May 7, 2015 Category: Global & Universal Source Type: news

Radon Testing: Community Engagement By a Rural Family Medicine Office
Conclusions: Four of 5 homes tested had elevated radon levels. This family medicine office/university collaborative educational model could be useful for educating patients about other environmental dangers.
Source: Journal of the American Board of Family Medicine - September 9, 2015 Category: Primary Care Authors: Levy, B. T., Wolff, C. K., Niles, P., Morehead, H., Xu, Y., Daly, J. M. Tags: Original Research Source Type: research

The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing
Personalized medicine relies upon the successful identification and translation of predictive biomarkers. Unfortunately, biomarker development has often fallen short of expectations. To better understand the obstacles to successful biomarker development, we systematically mapped research activities for a biomarker that has been in development for at least 12 years: excision repair cross-complement group 1 protein (ERCC1) as a biomarker for predicting clinical benefit with platinum-based chemotherapy in non-small cell lung cancer. We found that although research activities explored a wide range of approaches to ERCC1 testin...
Source: The Oncologist - January 25, 2017 Category: Cancer & Oncology Authors: Barsanti-Innes, B., Hey, S. P., Kimmelman, J. Tags: Review, Precision Medicine, Cancer Diagnostics and Molecular Pathology Source Type: research

Traditional Chinese medicine, Fuzheng Kang ‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway.
Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway. Mol Med Rep. 2017 Jun 30;: Authors: Li L, Wang S, Yang X, Long S, Xiao S, Wu W, Hann SS Abstract Lung cancer is a leading cause of cancer‑associated mortality worldwide, including in developing countries such as China. Traditional Chinese medicine may provide a novel insight for the treatment of patients with lung cancer. The present study aimed to uncover the mechanism by which the Chinese herbal medicine, Fuzheng Kang‑Ai (FZKA), functions on lung cancer cell metastas...
Source: Molecular Medicine Reports - July 6, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Personalised medicine for nonsmall cell lung cancer
After years of standard care prescribed to cancer patients without any selection except the primary site and histology of the tumour, the era of precision medicine has revolutionised cancer care. Personalised medicine refers to the selection of patients for specific treatment based on the presence of specific biomarkers which indicate sensitivity to corresponding targeted therapies and/or lower toxicity risk, such that patients will have the greatest chance of deriving benefit from the treatments. Here, we review personalised medicine for nonsmall cell lung cancer.
Source: European Respiratory Review - November 15, 2017 Category: Respiratory Medicine Authors: Mascaux, C., Tomasini, P., Greillier, L., Barlesi, F. Tags: Pulmonary pharmacology and therapeutics, Lung cancer Personalised Medicine in Respiratory Diseases Source Type: research

Traditional Chinese Medicine Integrated with Chemotherapy for Stage II-IIIA Patients with Non-Small-Cell Lung Cancer after Radical Surgery: A Retrospective Clinical Analysis with Small Sample Size.
Conclusion: Adjuvant therapy with TCM may reduce the rate of tumor recurrence and metastasis and prolong DFS of patients with stage II-IIIA NSCLC. PMID: 30147731 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - August 29, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese herbal medicine for small cell lung cancer patients: A protocol for a systematic review and meta-analysis
Background: Small cell lung cancer (SCLC) is an aggressive disease. Chemotherapy is the standard treatment for SCLC, but the resistance and the adverse effects of Chemotherapy still remains a major problem. Although Chinese herbal medicine (traditional Chinese medicine) is wildly applied for patients with SCLC in China, the evidence of traditional Chinese medicine in the treatment for SCLC is limited. Method: We conducted a systematic search of PubMed, EMBASE, the Chinese National Knowledge Infrastructure, the VIP Information Database, and the Wanfang Database for relevant studies. Only randomized controlled tri...
Source: Medicine - December 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

The evolving paradigm of precision medicine in lung cancer
Purpose of review In this review, we report a complete and updated summary of the most recent treatment advances in the fields of oncogene-addicted disease and provide expert perspectives on the evolving paradigm of precision medicine in lung cancer patients. Recent findings The advent of innovative genome sequencing technologies is rapidly increasing the number of targetable molecular alterations in advanced nonsmall cell lung cancer (NSCLC), leading to the introduction of novel selective inhibitors into the clinical arena, showing unprecedent tumor responses against rare and elusive NSCLC targets. The results ...
Source: Current Opinion in Pulmonary Medicine - June 8, 2021 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

External Application of Traditional Chinese Medicine in the Prevention and Treatment of Nausea and Vomiting Caused by Chemotherapy of Non-Small-Cell Lung Cancer: A RCT Study
CONCLUSION: External application of traditional Chinese medicine can significantly reduce nausea and vomiting caused by chemotherapy of non-small-cell lung cancer and can improve the patient's body and quality of life, which is worthy of clinical research and promotion.PMID:35966745 | PMC:PMC9371830 | DOI:10.1155/2022/6992673
Source: Evidence-based Complementary and Alternative Medicine - August 15, 2022 Category: Complementary Medicine Authors: Song-Jing Zhou Lin Tang Yong-Jun Fu Chang-Qing Yang Jia Shi Source Type: research