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Cancer: Prostate Cancer
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A modeling study to estimate prostate cancer ‐specific mortality on active surveillance for men with favorable intermediate‐risk prostate cancer: Results from the SEARCH cohort
ConclusionsThe risk of death for FIR after RP is very low. Assuming even modestly increased PCSM with AS versus RP, the excess risk of death for AS in FIR is low even up to 15 years. These data support the consideration of AS as a relatively safe alternative to RP in FIR men, though prospective randomized trials are needed to validate these findings.
Source: Cancer Medicine - April 9, 2023 Category: Cancer & Oncology Authors: Paige K. Kuhlmann,
Taofik Oyekunle,
Zachary Klaassen,
Christopher L. Amling,
William J. Aronson,
Matthew R. Cooperberg,
Christopher J. Kane,
Martha K. Terris,
Stephen J. Freedland Tags: RESEARCH ARTICLE Source Type: research
Aberrant Vascular Anatomy Associated With Artifactual Focal Avidity in the Liver on PSMA PET
We present a series of cases showing physiologic focal PSMA avidity in hepatic segment IVb. We correlate this uptake with aberrant hepatic vasculature. The awareness of this variant is important for accurate image interpretation to prevent additional invasive procedures, undue treatment escalation, and denial of curative treatment to patients.PMID:37385218 | DOI:10.1097/RLU.0000000000004765
Source: Clinical Prostate Cancer - June 29, 2023 Category: Cancer & Oncology Authors: Ismaheel O Lawal Melina Pectasides Ashwin Singh Parihar Hardik U Shah Raghuveer K Halkar Ashesh B Jani David M Schuster Source Type: research
Are associations between obesity and prostate cancer outcomes following radical prostatectomy the same in smokers and non-smokers? Results from the SEARCH Cohort
ConclusionsWhile our results are consistent with obesity as a risk factor for PCSM, we present evidence of effect modification by smoking for BCR and ACM highlighting the importance of stratifying by smoking status to better understand associations with body weight.
Source: Cancer Causes and Control - July 5, 2023 Category: Cancer & Oncology Source Type: research
Testosterone and peripheral arterial disease
Curr Vasc Pharmacol. 2023 Aug 9. doi: 10.2174/1570161121666230809143023. Online ahead of print.ABSTRACTTestosterone levels in men begin declining in the early years of adulthood, with a 1-2% reduction/year. Low testosterone levels in men are associated with obesity, metabolic syndrome, diabetes mellitus, dyslipidaemia, hypertension and increased cardiovascular mortality. However, observational studies of testosterone levels in males and their relationship with peripheral arterial disease (PAD) have yielded mixed results; only some cohorts show a clear association with low free testosterone levels. This discrepancy may, in ...
Source: Current Vascular Pharmacology - August 10, 2023 Category: Drugs & Pharmacology Authors: None Blinc A None Schernthaner Gh None Poredo š P None Anagnostis P None Jensterle M Bajuk Studen K None Antignani Pl None Mikhailidis Dp None Šabović M Source Type: research
Relative search popularity of five advanced prostate cancer medications using Google Trends
Prostate Cancer and Prostatic Diseases, Published online: 08 September 2023; doi:10.1038/s41391-023-00716-9Relative search popularity of five advanced prostate cancer medications using Google Trends
Source: Prostate Cancer and Prostatic Diseases - September 8, 2023 Category: Urology & Nephrology Authors: Sanjay Das Nadine A. Friedrich James Daniels G. Cecilia Galvan Jun Gong Edwin Posadas William Aronson Stephen J. Freedland Source Type: research
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
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Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives
In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
