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Total 26026 results found since Jan 2013.

IL‐17 and insulin/IGF1 enhance adhesion of prostate cancer cells to vascular endothelial cells through CD44‐VCAM‐1 interaction
CONCLUSIONSCD44‐VCAM‐1 interaction mediates the adhesion between prostate cancer cells and HUVECs. IL‐17 and insulin/IGF1 enhance adhesion of prostate cancer cells to vascular endothelial cells through increasing VCAM‐1 expression in the vascular endothelial cells. These findings suggest that IL‐17 may act with insulin/IGF1 to promote prostate cancer metastasis. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - February 15, 2015 Category: Urology & Nephrology Authors: Chong Chen, Qiuyang Zhang, Sen Liu, Keshab R. Parajuli, Yine Qu, Jiandong Mei, Zhiquan Chen, Hui Zhang, Damir B. Khismatullin, Zongbing You Tags: Original Article Source Type: research

Microstructural Characterization of Normal and Malignant Human Prostate Tissue With Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours Magnetic Resonance Imaging
Conclusions: The VERDICT model distinguished tumor from benign areas, while revealing differences in microstructure descriptors such as cellular, vascular, and EES fractions. The parameters of ADC and kurtosis models also discriminated between cancer and benign regions. However, VERDICT provides more specific information that disentangles the various microstructural features underlying the changes in ADC and kurtosis. These results highlight the clinical potential of the VERDICT framework and motivate the construction of a shorter, clinically viable imaging protocol to enable larger trials leading to widespread translation of the method.
Source: Investigative Radiology - March 10, 2015 Category: Radiology Tags: Original Articles Source Type: research

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer.
Authors: Kalmuk J, Folaron M, Buchinger J, Pili R, Seshadri M Abstract The high mortality rate associated with castration-resistant prostate cancer (CRPC) underscores the need for improving therapeutic options for this patient population. The purpose of this study was to examine the potential of vascular targeting in prostate cancer. Experimental studies were carried out in subcutaneous and orthotopic Myc-CaP prostate tumors implanted into male FVB mice to examine the efficacy of a novel microtubule targeted vascular disrupting agent (VDA), EPC2407 (Crolibulin™). A non-invasive multimodality imaging approach base...
Source: Oncotarget - July 26, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Non-invasive magnetic resonance-guided high intensity focused ultrasound ablation of a vascular malformation in the lower extremity: a case report
Conclusions In conclusion, we reported a successful non-invasive treatment of a vascular malformation with MR-HIFU in a clinical patient including long-term follow-up data for the first time. The patient reported qualitatively sustained pain reduction up to 13 months post treatment.
Source: Journal of Therapeutic Ultrasound - December 30, 2015 Category: Radiology Source Type: research

Endoscopic Vascular Targeted Photodynamic Therapy with the Photosensitizer WST11 for Benign Prostatic Hyperplasia in the Preclinical Dog Model
Conclusions: We confirmed the vascular effect of endourethral WST11 vascular targeted photodynamic therapy. To our knowledge we report for the first time that the resulting periurethral necrosis led to significant, sustained widening of the prostatic urethra, accompanied by long-term improvement in urodynamic parameters. These findings support future clinical applications of this minimally invasive approach to benign prostatic hyperplasia.
Source: The Journal of Urology - May 15, 2013 Category: Urology & Nephrology Authors: Simone Chevalier, Fabio L. Cury, Eleonora Scarlata, Ehab El-Zayat, Lucie Hamel, Joice Rocha, Fatima Z. Zouanat, Sabri Moussa, Avigdor Scherz, Mostafa Elhilali, Maurice Anidjar Tags: Investigative Urology Source Type: research

Primary research only search in Trip
I thought I would share this tip.Via twitter I was asked by @AliceMBuchan if it was possible to restrict the results to all the primary research articles.  Currently, we have four separate primary research 'sections':Key primary research (e.g. NEJM, Lancet, Evidence Updates)Controlled trialsExtended primary research - around 300 'high impact' journalsCase reports - taken from the Cases DatabaseFor secondary research we have a filter that allows a user to select 'All Secondary Evidence' but nothing similar for primary research.  While I'm not sure there is demand for an 'All Primary Research' button I've been able...
Source: Liberating the literature - March 7, 2014 Category: Technology Consultants Source Type: blogs

TM4SF1: a new vascular therapeutic target in cancer
Abstract Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal antibodies against human TM4SF1 in order to evaluate their therapeutic potential; 13 of the antibodies we generated reacted with extracellular loop-2 (EL2), TM4SF1’s larger extracellular, lumen-facing domain. However, none of these antibodies reacted with mouse TM4SF1, likely because the E...
Source: Angiogenesis - July 2, 2014 Category: Molecular Biology Source Type: research

The relationship between the 18F-NaF and calcium on the time course of vascular calcification.
Conclusion: NaF vascular uptake predicts calcification 1 -1.5 years after the scan. Research Support: SNMMI Wagner-Torizuka Fellowship and Uehara Memorial Foundation to TN.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Nakahara, T., Narula, J., Strauss, H. W. Tags: Nuclear Cardiology: New Tracers and Methods Source Type: research

Gene expression feature selection for prostate cancer diagnosis using a two-phase heuristic–deterministic search strategy
Here, a two-phase search strategy is proposed to identify the biomarkers in gene expression data set for the prostate cancer diagnosis. A statistical filtering method is initially employed to remove the noisiest data. In the first phase of the search strategy, a multi-objective optimisation based on the binary particle swarm optimisation algorithm tuned by a chaotic method is proposed to select the optimal subset of genes with the minimum number of genes and the maximum classification accuracy. Finally, in the second phase of the search strategy, the cache-based modification of the sequential forward floating selection alg...
Source: IET Systems Biology - August 14, 2018 Category: Biology Source Type: research

LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis
Conclusion: Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis. Introduction Infant hemangioma (IH) is a benign neoplasm commonly seen in childhood, which is more common in premature infants and infants with low birth weight (Smith et al., 2017). There are three distinct clinical histological stages in IH: the early proliferative stage, when undeveloped blood vessels are rapidly growing; plateau stage and final regressive stage, with scattered capillaries and large drainage vessels (Csoma et al., 2017). IH is characterize...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

In Search for risk predictors at the microscopic scenario of a negative biopsy. A systematic review.
CONCLUSIONS: The MS of a negative PB may include atypical small acinar proliferation, HGPIN, prostatic atrophy, inflammatory proliferative atrophy and prostatic inflammation lesions, since they all seem to be associated with the risk of PC detection in repeat PB. This review has led us to create the hypothesis that the MS of a negative PB might be a valuable and useful tool when considering repeat PB. PMID: 31109736 [PubMed - as supplied by publisher]
Source: Actas Urologicas Espanolas - May 16, 2019 Category: Urology & Nephrology Authors: Schwartzmann I, Celma A, Gallardo I, Moreno O, Regis L, Placer J, Planas J, Trilla Herrero E, Morote Robles J Tags: Actas Urol Esp Source Type: research

Internet use after prostate cancer : Search for information and trust in disease-related information in long-term survivors.
CONCLUSIONS: Two-thirds of long-term PCa survivors are using the internet. A significant proportion expressed difficulties finding proper and reliable information. Urologists should be familiar with online resources on PCa in order to offer advice to patients and to recommend adequate information on the internet. PMID: 31172242 [PubMed - as supplied by publisher]
Source: Der Urologe. Ausg. A - June 5, 2019 Category: Urology & Nephrology Authors: Linden AJ, Dinkel A, Schiele S, Meissner VH, Gschwend JE, Herkommer K Tags: Urologe A Source Type: research

Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator.
Abstract Ginsenoside Rb1 (Rb1), a major component of ginseng, has a steroidal chemical structure, implying that it exerts sex hormone-like actions. Recent studies have been suggested cardioprotective actions of Rb1. However, the actions of Rb1 in vascular calcification, one of the significant pathological features associated with aging and atherosclerosis, have not been examined. In the present study, we examined the effects of Rb1 on vascular calcification, focusing on its androgen-like actions. Using inorganic phosphate (Pi)-induced calcification of vascular smooth muscle cells (VSMC), we found that Rb1, like te...
Source: European Journal of Pharmacology - July 14, 2019 Category: Drugs & Pharmacology Authors: Nanao-Hamai M, Son BK, Komuro A, Asari Y, Hashizume T, Takayama KI, Ogawa S, Akishita M Tags: Eur J Pharmacol Source Type: research

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis
CONCLUSION: PCA3 served as a biomarker of CAS and regulates the function of VSMCs through sponging miR-124-3p/ITGB1 and indirectly influence the stability of plaque.PMID:37583257 | DOI:10.1177/10760296231190383
Source: Clinical Prostate Cancer - August 16, 2023 Category: Cancer & Oncology Authors: Guosheng Li Qiang Chen Source Type: research