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Total 26026 results found since Jan 2013.

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis
CONCLUSION: PCA3 served as a biomarker of CAS and regulates the function of VSMCs through sponging miR-124-3p/ITGB1 and indirectly influence the stability of plaque.PMID:37583257 | DOI:10.1177/10760296231190383
Source: Clinical Prostate Cancer - August 16, 2023 Category: Cancer & Oncology Authors: Guosheng Li Qiang Chen Source Type: research

Modeling human tumor angiogenesis in a three-dimensional culture system
The intrinsic complexity of the process of vessel formation limits the efficacy of cellular assays for elucidation of its molecular and pharmacologic mechanisms. We developed an ex vivo three-dimensional (3D) assay of sprouting angiogenesis with arterial explants from human umbilical cords. In this assay, human arterial rings were embedded in basement membrane extract gel, leading to a network of capillarylike structures upon vascular endothelial growth factor (VEGF) A stimulation. The angiogenic outgrowth consisted of endothelial cells, which actively internalized acetylated–low-density lipoprotein, surrounded by pe...
Source: Blood - May 23, 2013 Category: Hematology Authors: Seano, G., Chiaverina, G., Gagliardi, P. A., di Blasio, L., Sessa, R., Bussolino, F., Primo, L. Tags: Vascular Biology, e-Blood Source Type: research

Prostate cell lines as models for biomarker discovery: Performance of current markers and the search for new biomarkers
CONCLUSIONSWhile the existing prostate cancer biomarkers and lysosomal proteins investigated here were not able to specifically differentiate between a panel of nonmalignant and prostate cancer cell lines, endosomal proteins showed some discriminatory capacity. LIMP‐2 is a critical regulator of endosome biogenesis and the increased expression observed in prostate cancer cells indicated that other endosome related proteins may also be upregulated and could be investigated as novel biomarkers. Prostate © 2014 Wiley Periodicals, Inc.
Source: The Prostate - January 16, 2014 Category: Urology & Nephrology Authors: Ian R. Johnson, Emma J. Parkinson‐Lawrence, Lisa M. Butler, Doug A. Brooks Tags: Original Article Source Type: research

Increased insulin mRNA binding protein-3 expression Correlates with vascular enhancement of renal cell carcinoma by intravenous contrast-CT and Is associated with bone metastasis
Conclusion Quantitation of pre-operative CT is a feasible method to phenotype primary RCC vascularity, which correlates with IMP-3 expression. In situ and cell line studies demonstrate an association between high IMP-3 expression and RCC bone metastasis. Studies aimed at defining the diagnostic potential of biomarkers for RCC bone metastasis, and functional significance of IMP-3 in RCC vascularity and tumor progression are warranted.
Source: Journal of Bone Oncology - September 13, 2015 Category: Cancer & Oncology Source Type: research

PSGR olfactory receptor: A new potential target in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare progressive disease due to distal vascular remodeling, leading to right heart failure and death. PSGR is an olfactory receptor (OR) that has been recently detected in peripheral tissues. Moreover, PSGR overexpression is associated with pro-proliferative phenotype in prostate cancer. Since PAH vascular cells are characterized by cancer-like over-proliferation, we hypothesized that PSGR might participate in the vascular remodeling leading to PAH.Here we aimed to determine whether upregulation of PSGR is implicated in PAH pathological phenotype, and to explore PSGR as a novel th...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Courboulin, A., Quatredeniers, M., Sanz, G., Breuils-Bonnet, S., Vocelle, M., Lafond, M., Perros, F., Bonnet, S., Pajot-Augy, E., Humbert, M., Cohen-Kaminsky, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases Source Type: research

Bombesin Antagonist Based Radiotherapy of Prostate Cancer Combined with WST-11 Vascular Targeted Photodynamic Therapy.
CONCLUSIONS: Tumor vascular arrest by VTP improves 90Y-DOTA-AR retention in the tumor microenvironment thereby enhancing therapeutic efficacy. PMID: 28108545 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - January 19, 2017 Category: Cancer & Oncology Authors: Kim K, Zhang H, LaRosa S, Jebiwott S, Desai P, Kimm SY, Scherz AJ, O'Donoghue JA, Weber WA, Coleman J Tags: Clin Cancer Res Source Type: research

First postoperative PSA is associated with outcomes in patients with node positive prostate cancer: Results from the SEARCH database.
CONCLUSIONS: pN1 patients with a first postoperative PSA ≥0.2ng/ml were more likely to develop metastases. First postoperative PSA may be useful in identifying pN1 patients who harbor distant disease and aid in secondary treatment decisions. PMID: 29429895 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 8, 2018 Category: Urology & Nephrology Authors: McDonald ML, Howard LE, Aronson WJ, Terris MK, Cooperberg MR, Amling CL, Freedland SJ, Kane CJ Tags: Urol Oncol Source Type: research

Radical Prostatectomy and the Effect of Close Surgical Margins: Results from the SEARCH database
ConclusionsManagement of men with close surgical margins is a diagnostic challenge, with a disease course that is not entirely benign. Evaluation of other known risk factors likely provide greater prognostic value for these men and may ultimately better select those who may benefit from adjuvant therapy.This article is protected by copyright. All rights reserved.
Source: BJU International - February 1, 2018 Category: Urology & Nephrology Authors: Christine Herforth, Sean P. Stroup, Zinan Chen, Lauren E. Howard, Stephen J. Freedland, Daniel M. Moreira, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane Tags: Original Article Source Type: research

Molecules, Vol. 23, Pages 567: Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
heng Luo Kai Chen SET7, serving as the only histone methyltransferase that monomethylates ‘Lys-4’ of histone H3, has been proved to function as a key regulator in diverse biological processes, such as cell proliferation, transcriptional network regulation in embryonic stem cell, cell cycle control, protein stability, heart morphogenesis and development. What′s more, SET7 is involved inthe pathogenesis of alopecia aerate, breast cancer, tumor and cancer progression, atherosclerosis in human carotid plaques, chronic renal diseases, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular carcinoma, and ...
Source: Molecules - March 2, 2018 Category: Chemistry Authors: Hong Ding Wen Lu Jun Hu Yu-Chih Liu Chen Zhang Fu Lian Nai Zhang Fan Meng Cheng Luo Kai Chen Tags: Article Source Type: research

Socioeconomic status, race, and long-term outcomes after radical prostatectomy in an equal access health system: Results from the SEARCH database.
CONCLUSIONS: In an equal-access setting, lower SES associated with decreased CRPC, metastases, and PCSM in black but not white men. If confirmed, these findings suggest a complex relationship between race, SES, and PC with further research needed to understand why low SES in black men decreased the risk for poor PC outcomes after RP. PMID: 30598238 [PubMed - as supplied by publisher]
Source: Urologic Oncology - December 28, 2018 Category: Urology & Nephrology Authors: Everist MM, Howard LE, Aronson WJ, Kane CJ, Amling CL, Cooperberg MR, Terris MK, Freedland SJ Tags: Urol Oncol Source Type: research

In Search for risk predictors at the microscopic scenario of a negative biopsy. A systematic review
ConclusionsThe MS of a negative PB may include atypical small acinar proliferation, HGPIN, prostatic atrophy, inflammatory proliferative atrophy and prostatic inflammation lesions, since they all seem to be associated with the risk of PC detection in repeat PB. This review has led us to create the hypothesis that the MS of a negative PB might be a valuable and useful tool when considering repeat PB.ResumenIntroducciónLas biopsias prostáticas (BP) de repetición, ante la persistencia de la sospecha de cáncer de próstata (CP), son frecuentes y su rendimiento bajo. En el contexto de una BP negativa existe un escenario mic...
Source: Actas Urologicas Espanolas - July 27, 2019 Category: Urology & Nephrology Source Type: research

Cancers, Vol. 11, Pages 1356: Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Na ïve Prostate Carcinomas Undergoing Radical Prostatectomy
This study aimed toevaluate the prognostic significance of vascular (VV) and lymphatic vessels (LV) in prostate cancer(PCa). Tumor samples from 400 PCa patients undergoing radical prostatectomy (RP) were preparedin duplex as tissue microarrays. Numbers of VV and LV were evaluated usingimmunohistochemistry detecting CD34 and podoplanin, respectively, and correlated to clinicaldata, biochemical recurrence (BR), and proteins analyzed in tumor cells. VVlow and LV were foundin 32% and 43% of patients with informative PCa samples, respectively. VVlow correlated with ashorter time to BR 3, 5, and 10 years after RP in hormone-na&a...
Source: Cancers - September 11, 2019 Category: Cancer & Oncology Authors: Smentoch Szade Żaczek Eltze Semjonow Brandt Bednarz-Knoll Tags: Article Source Type: research

Targeting MET and Vascular Endothelial Growth Factor Receptor Signaling in Castration-Resistant Prostate Cancer.
Abstract ABSTRACT: Effective management of bone metastases in men with castration-resistant prostate cancer (CRPC) remains an important unmet medical need. MET and vascular endothelial growth factor receptor (VEGFR) are rational targets for intervention in CRPC. Clinical trials involving agents that inhibit one but not both pathways have reported modest activity and no improvement in overall survival. Cabozantinib is an oral multitargeted tyrosine kinase inhibitor that inhibits both MET and VEGFR-2. A phase II randomized discontinuation study involving subjects with CRPC demonstrated that cabozantinib therapy is a...
Source: Cancer Journal - January 1, 2013 Category: Cancer & Oncology Authors: Lee RJ, Smith MR Tags: Cancer J Source Type: research

In vitro and in vivo imaging of prostate cancer angiogenesis using anti-vascular endothelial growth factor receptor 2 antibody-conjugated quantum dot.
CONCLUSION: By showing endothelial cells binding with QDs-antiVEGFR2 antibodyand an experimental application of the antibody for VEGFR2 imaging in the prostate cancer xenograft mouse model, we suggests that the antibody-conjugated QDs can be a potential imaging tool for angiogenesis of the cancer. PMID: 23323028 [PubMed - in process]
Source: Korean J Radiol - January 1, 2013 Category: Radiology Authors: Kwon H, Lee J, Song R, Hwang SI, Lee J, Kim YH, Lee HJ Tags: Korean J Radiol Source Type: research