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Cancer: Prostate Cancer

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Total 26026 results found since Jan 2013.

Aromatic Hydrocarbon Receptor Inhibits Lysophosphatidic Acid-Induced Vascular Endothelial Growth Factor-A Expression in PC-3 Prostate Cancer Cells.
In conclusion, our results suggested that AHR activation may inhibit LPA-induced VEGF-A expression in PC-3 cells by attenuating HIF-1α signaling, and subsequently, suppressing angiogenesis and metastasis of PC. These results suggested that AHR presents a potential therapeutic target for the prevention of PC metastasis. PMID: 23831623 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - July 3, 2013 Category: Biochemistry Authors: Wu PY, Lin YC, Lan SY, Huang YL, Lee H Tags: Biochem Biophys Res Commun Source Type: research

Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer.
CONCLUSIONS: Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population. PMID: 24240584 [PubMed - in process]
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2013 Category: Cancer & Oncology Authors: Martinez-Fierro ML, Garza-Veloz I, Rojas-Martinez A, Ortiz-Lopez R, Castruita-de la Rosa C, Ortiz-Castro Y, Lazalde-Ramos BP, Cervantes-Villagrana AR, Castañeda-Lopez ME, Gomez-Guerra L, Delgado-Enciso I, Martinez-Torres AA Tags: Cancer Biomark Source Type: research

Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells.
Abstract Prostate cancer is the most commonly diagnosed malignancy in men and shows a tendency for metastasis to distant organs. Angiogenesis is required for metastasis. Bradykinin (BK) is an inflammatory mediator involved in tumor growth and metastasis, but its role in vascular endothelial growth factor (VEGF) expression and angiogenesis in human prostate cancer remains unknown. The aim of this study was to examine whether BK promotes prostate cancer angiogenesis via VEGF expression. We found that exogenous BK increased VEGF expression in prostate cancer cells and further promoted tube formation in endothelial pr...
Source: Biochemical Pharmacology - November 10, 2013 Category: Drugs & Pharmacology Authors: Yu HS, Wang SW, Chang AC, Tai HC, Yeh HI, Lin YM, Tang CH Tags: Biochem Pharmacol Source Type: research

Modulation of Blood Flow, Hypoxia, and Vascular Function in Orthotopic Prostate Tumors During Exercise
Conclusions During exercise there is enhanced tumor perfusion and diminished tumor hypoxia due, in part, to a diminished vasoconstriction. The clinical relevance of these findings are that exercise may enhance the delivery of tumor-targeting drugs as well as attenuate the hypoxic microenvironment within a tumor and lead to a less aggressive phenotype.
Source: JNCI - April 8, 2014 Category: Cancer & Oncology Authors: McCullough, D. J., Stabley, J. N., Siemann, D. W., Behnke, B. J. Tags: Article Source Type: research

Vascular-targeted photodynamic therapy with TOOKAD ® Soluble in localized prostate cancer: standardization of the procedure
Conclusion Based on the experience gained through hundreds of procedures, we describe here the standardized technique of vascular-targeted photodynamic therapy with TOOKAD® Soluble defined during the phase II and III trials.
Source: World Journal of Urology - March 19, 2015 Category: Urology & Nephrology Source Type: research

Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.
Authors: Ader I, Gstalder C, Bouquerel P, Golzio M, Andrieu G, Zalvidea S, Richard S, Sabbadini RA, Malavaud B, Cuvillier O Abstract Hypoxia promotes neovascularization, increased tumor growth, and therapeutic resistance. The transcription factor, hypoxia-inducible factor 1α (HIF-1α), has been reported as the master driver of adaptation to hypoxia. We previously identified the sphingosine kinase 1/sphingosine 1-phosphate (SphK1/S1P) pathway as a new modulator of HIF-1α under hypoxia. Taking advantage of a monoclonal antibody neutralizing extracellular S1P (sphingomab), we report that inhibition of S1P extracellu...
Source: Oncotarget - May 2, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract 3304: Role of Vascular Endothelial Growth Factor C in promoting radioresistance of prostate cancer
In this study we have evaluated the role of VEGF-C and VEGF-C induced autophagy in radioresistance of prostate cancer using cell culture experiments and human tissue samples.The human prostate carcinoma cell lines PC-3, LNCaP and DU145 were used in these cell culture experiments. Clonogenic survival of prostate cancer cells, after RNA interference (RNAi) of VEGF-C, autophagy related gene 5 (ATG5), and after addition of recombinant human VEGF-C following irradiation therapy, was evaluated. Autophagic flux was tested after ionizing irradiation using a Light-Chain-3 II immunoblot. To confirm our in vitro findings, human tissu...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Haberlau, S., Honscheid, P., Jimenez, R. E., Baretton, G. B., Tindall, D. J., Krause, M., Datta, K., Muders, M. H. Tags: Tumor Biology Source Type: research

Correlations between intratumoral interstitial fibrillary network and vascular network in Srigley patterns of prostate adenocarcinoma.
CONCLUSIONS: Our results could plead for the hypothesis that the different subtypes of tumor architecture represent steps of a continuous process from well-differentiated status to poorly or undifferentiated status but who is accomplished by two different tumor cells populations with different distinct behavior in their relationship with the stromal microenvironment. PMID: 26743277 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - January 15, 2016 Category: Journals (General) Tags: Rom J Morphol Embryol Source Type: research

An observational study of plasma vascular endothelial growth factors (VEGF) A and D expression in non-localized prostate cancer.
CONCLUSIONS: Higher plasma VEGF-D than VEGF-A expression in advanced PCa stages suggests a greater role for VEGF-D dependent lymph angiogenesis in advanced stage PCa, which needs further evaluation. PMID: 24416090 [PubMed - as supplied by publisher]
Source: Journal of Men's Health - February 11, 2016 Category: Primary Care Tags: J Mens Health Source Type: research

Differences in Hypercholesterolemia and Atherogenesis Induced by Common Androgen Deprivation Therapies in Male Mice Vascular Medicine
Conclusions No differences in the development of atherosclerosis were detected among groups of intact Apoe-deficient mice treated with different types of ADT. A pro-atherogenic, possibly cholesterol-mediated, effect of leuprolide was seen in orchiectomized mice that might be relevant for understanding the potential cardiovascular risk associated with GnRH agonist-based ADT.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Poulsen, C. B., Mortensen, M. B., Koechling, W., Sorensen, C. B., Bentzon, J. F. Tags: Animal Models of Human Disease, Vascular Biology, Atherosclerosis Vascular Medicine Source Type: research

Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and vascular endothelial growth factors and cyclooxygenase-2 in prostate cancer.
Abstract Limited information is available on the pathologic significance of human antigen R (HuR) in prostate cancer (PCa). The main aim of this study was to clarify the relationship between HuR expression and malignant aggressiveness, outcome, and expression of cancer-related molecules in PCa. In vitro proliferation, colony formation, and migration assays were performed on LNCaP and PC-3 cells. HuR expression was knocked down (KD) using small interfering RNA. The relationships between HuR expression and the expression of vascular endothelial growth factors (VEGFs), cyclooxygenase (COX)-2, and heme oxygenase (HO...
Source: Translational Research : the journal of laboratory and clinical medicine - April 28, 2016 Category: Laboratory Medicine Authors: Mitsunari K, Miyata Y, Asai A, Matsuo T, Shida Y, Hakariya T, Sakai H Tags: Transl Res Source Type: research

Iroquois Homeobox Transcription Factor (Irx5) Promotes G1/S-Phase Transition in Vascular Smooth Muscle Cells by CDK2-dependent Activation.
Abstract The Iroquois homeobox gene (Irx5) is essential in the embryonic development and cardiac electrophysiology. Although recent studies have reported that IRX5 is involved in the regulation of cell cycle and apoptosis in prostate cancer cells, little is known about the role of IRX5 in the adult vasculature. Here we report novel observations on the role of IRX5 in adult vascular smooth muscle cells (VSMCs) during proliferation in vitro and in vivo. Comparative studies to determine relative expression of Irx5 expression in the peripheral vasculature using primary human endothelial cells (HUVECs), VSMCs, and inta...
Source: Am J Physiol Cell Ph... - May 10, 2016 Category: Cytology Authors: Liu D, Pattabiraman V, Bacanamwo M, Anderson LM Tags: Am J Physiol Cell Physiol Source Type: research

Final Results of a Phase I/II Multicenter Trial of WST11 Vascular Targeted Photodynamic Therapy for Hemi-Ablation of the Prostate in Men with Unilateral Low Risk Prostate Cancer Performed in the United States
Vascular targeted photodynamic therapy with WST11 (TOOKAD® Soluble) is a form of tissue ablation that may be used therapeutically for localized prostate cancer. To study dosing parameters and associated treatment effects we performed a prospective, multicenter, phase I/II trial of WST11 vascular targeted photodynamic therapy of prostate cancer.
Source: The Journal of Urology - June 8, 2016 Category: Urology & Nephrology Authors: Samir S. Taneja, James Bennett, Jonathan Coleman, Robert Grubb, Gerald Andriole, Robert E. Reiter, Leonard Marks, Abdel-Rahmene Azzouzi, Mark Emberton Tags: Adult Urology Source Type: research

Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer
Poor oxygenation of solid tumours has been linked with resistance to chemo- and radio-therapy and poor patient outcomes, hence non-invasive imaging of oxygen supply and demand in tumours could improve disease staging and therapeutic monitoring. Optoacoustic tomography (OT) is an emerging clinical imaging modality that provides static images of endogenous haemoglobin concentration and oxygenation. Here, we demonstrate oxygen enhanced (OE)-OT, exploiting an oxygen gas challenge to visualise the spatiotemporal heterogeneity of tumour vascular function. We show that tracking oxygenation dynamics using OE-OT reveals significant...
Source: Theranostics - September 12, 2017 Category: Molecular Biology Authors: Michal R Tomaszewski, Isabel Quiros Gonzalez, James PB O'Connor, Oshaani Abeyakoon, Geoff JM Parker, Kaye J Williams, Fiona J Gilbert, Sarah E Bohndiek Tags: Research Paper Source Type: research