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Effects of Docetaxel plus Degarelix on Quality of Life and Vascular Endothelial Growth Factor in Patients with Prostate Cancer
CONCLUSION: Docetaxel plus degarelix can enhance the therapeutic efficacy of patients with prostate cancer, mitigate inflammatory response, inhibit the VEGF expression of cancer cells, and improve the patients' quality of life. Further clinical trials are, however, required prior to general use in clinical practice.PMID:35874639 | PMC:PMC9300361 | DOI:10.1155/2022/9082501
Source: Journal of Oncology - July 25, 2022 Category: Cancer & Oncology Authors: Weiping Li Dongbo Xu Fudong Li Pengcheng Chang Bin Zhang Source Type: research

Diabetes predicts metastasis after radical prostatectomy in obese men: results from the SEARCH database
Conclusions Diabetes was not associated with metastasis risk overall. Stratification by obesity yielded significant differences, with diabetes linked to a fourfold higher metastasis risk in obese men, despite predicting more aggressive secondary treatment. Longer diabetes duration was also associated with increased metastasis risk.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Chenwei Wu, William J. Aronson, Martha K. Terris, Joseph C. Presti, Christopher J. Kane, Christopher L. Amling, Stephen J. Freedland Tags: Urological Oncology Source Type: research

Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site
Conclusions: Our mechanistic study of androgen mediated induction of VEGF expression in prostate cancer cells revealed for the first time that this induction is mediated through the core promoter region and is dependent upon a critical Sp1 binding site. The importance of Sp1 binding suggests that therapy targeting the AR-Sp1 complex may dampen VEGF induced angiogenesis and, thereby, block prostate cancer progression, helping to maintain the indolent form of prostate cancer.
Source: Molecular Cancer - February 1, 2013 Category: Cancer & Oncology Authors: Kurtis EisermannCarly BroderickAnton BazarovMustafa MoazamGail Fraizer Source Type: research

Stromal cell-derived factor-1 and vascular endothelial growth factor as biomarkers for lymph node metastasis and poor cancer-specific survival in prostate cancer patients after radical prostatectomy
Conclusions: High expression levels of SDF-1, VEGF, and MMP-9 are more correlated with lymph node metastatic prostate carcinoma compared with non-lymph-node metastatic cancer. High expression levels of SDF-1 and VEGF strongly predict the biochemical progression in CaP patients after radical prostatectomy.
Source: Urologic Oncology: Seminars and Original Investigations - March 3, 2011 Category: Urology & Nephrology Authors: Qinwen Wang, Xinwei Diao, Jianguo Sun, Zhengtang Chen Tags: Clinical - Prostate Source Type: research

TOOKAD® Soluble Vascular Targeted Photodynamic (VTP) therapy: determination of optimal treatment conditions and assessment of effects in patients with localised prostate cancer
ConclusionBiopsy data, post‐treatment dynamic contrast enhancement MRI at 1 week post‐VTP and analysis of the safety data have shown that 4 mg/kg TOOKAD® Soluble and 200 J/cm light are the optimal treatment conditions for the VTP procedure resulting in more than 80% patients treated with this regimen reporting a negative biopsy at Month 6. Overall, the treatment was well tolerated and exhibited early signs of efficacy for minimally invasive focal treatment of localised prostate cancer.
Source: BJU International - June 5, 2013 Category: Urology & Nephrology Authors: Abdel‐Rahmène Azzouzi, Eric Barret, Caroline M Moore, Arnaud Villers, Clare Allen, Avigdor Scherz, Gordon Muir, Michel Wildt, Neil J Barber, Souhil Lebdai, Mark Emberton Tags: Urological Oncology Source Type: research

Influence of Vascular Comorbidities and Race on Erectile Dysfunction after Prostate Cancer Radiotherapy
ConclusionsThe number of VCs have a significant effect on development of post‐XRT ED. Pre‐ and post‐XRT ED appear to be independent of race when number of VCs are considered. Our results can be used to guide physicians in counseling patients on the incidence of ED by number of VC and as preliminary data for prospective efforts aimed at reducing post‐XRT ED. Wang Y, Liu T, Rossi PJ, Watkins‐Bruner D, Hsiao W, Cooper S, Yang X, and Jani AB. Influence of vascular comorbidities and race on erectile dysfunction after prostate cancer radiotherapy. J Sex Med **;**:**–**.
Source: The Journal of Sexual Medicine - June 6, 2013 Category: Sexual Medicine Authors: Yuefeng Wang, Tian Liu, Peter J. Rossi, Deborah Watkins‐Bruner, Wayland Hsiao, Sherrie Cooper, Xiaofeng Yang, Ashesh B. Jani Tags: Original Research Source Type: research

A Right Atrial Mass in a Patient With Metastatic Melanoma and Prostate Cancer
A 65-YEAR-OLD MAN with coronary artery disease (70% in-stent restenosis of the left anterior descending artery) and aortic valve stenosis (mean gradient 34 mmHg, valve area 0.8 cm2) presented for coronary artery bypass grafting and aortic valve replacement. His medical history was notable for prostate cancer treated with pelvic irradiation and metastatic melanoma of unknown primary site diagnosed on excisional biopsy of a neck mass. After anesthetic induction, a pulmonary artery catheter was inserted without difficulty through the right internal jugular vein. Transesophageal echocardiography (TEE) confirmed the aortic valv...
Source: Journal of Cardiothoracic and Vascular Anesthesia - May 16, 2012 Category: Anesthesiology Authors: Bryan G. Maxwell, Matthew Forrester, Michael J. Wagner Tags: Diagnostic Dilemmas Source Type: research

Pre-analytical-related variability influencing serum peptide profiles demonstrated in a mass spectrometry-based search for colorectal and prostate cancer biomarkers.
Abstract Although the degradome, which comprises proteolytic fragments of blood proteins, presents a potential source of diagnostic biomarkers, studies on cancer peptide biomarkers have provided inconsistent conclusions. In the present study, we reevaluated the usefulness of serum degradome analyses for searching peptide cancer biomarker candidates. Particular attention was paid to pre-analytical factors influencing the variability of determined peptide levels, including clotting time and control group selection. Studies were conducted on 44 and 86 serum samples collected from cancer patients and healthy individua...
Source: Acta Biochim Pol - September 18, 2013 Category: Biochemistry Authors: Karczmarski J, Rubel T, Mikula M, Wolski J, Rutkowski A, Zagorowicz E, Dadlez M, Ostrowski J Tags: Acta Biochim Pol Source Type: research

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
rman & S J Freedland
Source: Prostate Cancer and Prostatic Diseases - October 8, 2013 Category: Urology & Nephrology Authors: E H AllottM R AbernL GerberC J KetoW J AronsonM K TerrisC J KaneC L AmlingM R CooperbergP G MoormanS J Freedland Tags: metformin diabetes biochemical recurrence outcomes Source Type: research

Effects of exercise training on tumor hypoxia and vascular function in the rodent preclinical orthotopic prostate cancer model
Regular physical exercise is considered to be an integral component of cancer care strategies. However, the effect of exercise training on tumor microvascular oxygenation, hypoxia, and vascular function, all of which can affect the tumor microenvironment, remains unknown. Using an orthotopic preclinical model of prostate cancer, we tested the hypotheses that, after exercise training, in the tumor, there would be an enhanced microvascular Po2, increased number of patent vessels, and reduced hypoxia. We also investigated tumor resistance artery contractile properties. Dunning R-3327 AT-1 tumor cells (104) were injected into ...
Source: Journal of Applied Physiology - December 16, 2013 Category: Physiology Authors: McCullough, D. J., Nguyen, L. M.- D., Siemann, D. W., Behnke, B. J. Tags: ARTICLES Source Type: research

Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database
& S J Freedland
Source: Prostate Cancer and Prostatic Diseases - January 14, 2014 Category: Urology & Nephrology Authors: D M MoreiraM R CooperbergL E HowardW J AronsonC J KaneM K TerrisC L AmlingM KuchibhatlaS J Freedland Tags: disease-free survival metastasis mortality prostatectomy PSA Source Type: research

Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localized prostate cancer using WST11‐Vascular Targeted Photodynamic (VTP) therapy
Conclusion4mg/kg TOOKAD® Soluble activated by 753nm light at a dose of 200J/cmand an LDI >1 resulted in treatment effect in 95% of the plannedtreatment volume and a negative biopsy rate at 6 months of 83% in a group of 12 men.
Source: BJU International - May 1, 2014 Category: Urology & Nephrology Authors: Caroline M Moore, A R Azzouzi, E Barret, A Villers, G Muir, N Barber, J Trachtenberg, N Arumainayagam, B Gaillac, C Allen, A Schertz, M Emberton Tags: Urological Oncology Source Type: research

Colorectal carcinomas in 2013: The search for powerful prognostic markers is still on the go!
Abstract Colorectal cancer (CRC) is the third cause of cancer worldwide after prostate cancer and breast cancer. Patients have a survival rate of 5 years, which varies between 10 and 95% depending on the CRC stage. Today, the management of patients with CRC is based on parameters such as TNM and classic histologic parameters, but new molecular and cell markers have been created to improve treatment and survival. Determining the expression of a characteristic set of genes either from formalin-fixed paraffin-embedded tissues (Onco type DX test™) or from fresh tissues (AGENDIA© ColoPrint®) has led to encouraging ...
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2014 Category: Cancer & Oncology Authors: Coget J, Borrini F, Susman S, Sabourin JC Tags: Cancer Biomark Source Type: research

Inflammation: an important parameter in the search of prostate cancer biomarkers
Conclusions: The present study indicates that inflammation might be a confounding parameter during the proteomic research of candidate biomarkers of PCa. These results indicate that some possible biomarker-candidate proteins are strongly influenced by the presence of inflammation, hence only a well-selected protein pattern should be considered for potential marker of PCa.
Source: Proteome Science - June 9, 2014 Category: Bioinformatics Authors: Stefania BergaminiElisa BelleiLuca Reggiani BonettiEmanuela MonariAurora CuoghiFrancesco BorelliMaria SighinolfiGiampaolo BianchiTomris OzbenAldo Tomasi Source Type: research