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Cancer: Prostate Cancer
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Total 26026 results found since Jan 2013.
Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression
Because tumour-associated angiogenesis is crucial for solid malignancies including prostate cancer, inhibition of tumour neovascularization and/or destruction of tumour vasculature might maintain tumours in a dormant state or, in combination with cytotoxic therapies, may potentiate tumour shrinkage. Molecular targeted agents (mainly antagonists of vascular endothelial growth factor [VEGF] pathways) have been developed to block proangiogenic signal transduction. For example, bevacizumab, a humanized antibody against VEGF-A, was the first antiangiogenic agent to be approved for treatment of several advanced cancers [1].
Source: FEBS Letters - August 9, 2014 Category: Biochemistry Authors: Junya Kuroyanagi, Yasuhito Shimada, Beibei Zhang, Michiko Ariyoshi, Noriko Umemoto, Yuhei Nishimura, Toshio Tanaka Source Type: research
Venous Thrombo-embolism prophylaxis: Intermittent pneumatic compression
Publication date: December 2013 Source:Reviews in Vascular Medicine, Volume 1, Issue 4 Author(s): Mehmet Kurtoglu , Emre Sivrikoz Pulmonary embolism (PE) is the most preventable cause of hospital deaths in Europe. Autopsy-proven fatal pulmonary emboli were found in 2.5% of 200 hospitalized medical patients followed-up prospectively. The number of venous thrombo-embolism (VTE) related deaths throughout the Europe (543,454) is more than double the amount of deaths attributed to AIDS, breast cancer, prostate cancer and transport accidents combined (209,926). Only 58.5% of surgical patients and 39.5% of medical patients rece...
Source: Reviews in Vascular Medicine - November 6, 2014 Category: Cardiology Source Type: research
Abstract 83: Increased cyclooxygenase-2 and vascular endothelial growth factor protein expression is associated with canine prostatic carcionogenesis process
Conclusions: This study has demonstrated that the carcinogenesis of canine prostatic tissue may be related to gain of COX-2 and VEGF protein expression.
Financial Support: Sao Paulo State Foundation (FAPESP) and CNPq.
Note: This abstract was not presented at the meeting.
Citation Format: Renée Laufer Amorim, Carlos Eduardo Fonseca-Alves, Luis Gabriel Tivera Calderon, Andre Augusto Justo, Silvia Regina Rogatto. Increased cyclooxygenase-2 and vascular endothelial growth factor protein expression is associated with canine prostatic carcionogenesis process. [abstract]. In: Proceedings of the 105th Annual Meeting of the Americ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Amorim, R. L., Fonseca-Alves, C. E., Calderon, L. G. T., Justo, A. A., Rogatto, S. R. Tags: Tumor Biology Source Type: research
Abstract 111: In search of a lead fluorescent tracer for PSCA-expressing prostate cancer: A comprehensive analysis of imaging agents and dyes
Prostate stem cell antigen (PSCA) is over-expressed on the surface of many prostate cancer cells especially in castration-resistant and metastatic lesions. Thus, it is of great interest to develop PSCA-targeted imaging probes for cancer detection. To this end our group has generated anti-PSCA antibody fragments including minibodies and diabodies that can be fluorescently labeled via either site-specific or non-specific conjugations. We here report a detailed optimization of such labeling protocols and propose a lead imaging probe for PSCA+ prostate tumors. Male nude mice were bilaterally implanted with PSCA over-expressing...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Jiang, Z. K., Wu, A., Reiter, R. Tags: Cancer Chemistry Source Type: research
P1-5-2 * bradykinin promotes vascular endothelial growth factor-dependent angiogenesis in human prostate cancer
Conclusions: Our results demonstrate that bradykinin operates through the B2 receptor, Akt, and mTOR, which in turn activate NF-kB and AP-1, activating VEGF expression and contributing to angiogenesis in human prostate cancer.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Wang, S.-W., Lai, Y.-W., Tai, H.-C., Tang, C.-H. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research
P1-5-2 * bradykinin promotes vascular endothelial growth factor-dependent angiogenesis in human prostate cancer
Conclusions: Our results demonstrate that bradykinin operates through the B2 receptor, Akt, and mTOR, which in turn activate NF-kB and AP-1, activating VEGF expression and contributing to angiogenesis in human prostate cancer.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Wang, S.-W., Lai, Y.-W., Tai, H.-C., Tang, C.-H. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research
Prostate Cancer Recurrence Manifesting as Superior Vena Cava Syndrome
Publication date: Available online 7 March 2015 Source:Journal of Vascular and Interventional Radiology Author(s): Pouyan Golshani , Faramarz Edalat , Tarak H. Patel
Source: Journal of Vascular and Interventional Radiology - March 8, 2015 Category: Radiology Source Type: research
Androgen Deprivation Therapy Reversibly Increases Endothelium-Dependent Vasodilation in Men With Prostate Cancer Vascular Medicine
Conclusions
In contrast to our expectation, ADT improved endothelium-dependent vasodilation and its cessation returned endothelium-dependent vasodilation to baseline. Determining the mechanism of this change requires further investigation.
Source: JAHA:Journal of the American Heart Association - April 20, 2015 Category: Cardiology Authors: Nguyen, P. L., Jarolim, P., Basaria, S., Zuflacht, J. P., Milian, J., Kadivar, S., Graham, P. L., Hyatt, A., Kantoff, P. W., Beckman, J. A. Tags: Vascular Medicine Source Type: research
Regulation of vascular endothelial growth factor in prostate cancer
Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ~30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen-dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Such androgen deprivation therapies (ADT) are effective initially, but the duration of response is typically ≤24 months. Although ADT and taxane-based chemotherapy have deli...
Source: Endocrine-Related Cancer - May 20, 2015 Category: Endocrinology Authors: de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., Bates, D. O., Odum, N., Persson, J. L., Mongan, N. P. Tags: Review Source Type: research
Positive Surgical Margins in Radical Prostatectomy Patients Do Not Predict Long‐term Oncological Outcomes: Results from SEARCH
ConclusionsPSMs after RP are not an independent risk factor for CRPC, metastasis, or PCSM overall or within any subset. In the absence of other high‐risk features, PSMs alone may not be an indication for adjuvant treatment.This article is protected by copyright. All rights reserved.
Source: BJU International - May 25, 2015 Category: Urology & Nephrology Authors: Prabhakar Mithal, Lauren E. Howard, William J. Aronson, Martha K. Terris, Matthew R. Cooperberg, Christopher J. Kane, Christopher Amling, Stephen J. Freedland Tags: Original Article Source Type: research
Abstract 880: Obesity predicts prostate cancer-specific mortality after radical prostatectomy: Results from the SEARCH database
We examined the effect of obesity at the time of radical prostatectomy (RP) on long-term prostate cancer-specific outcomes among men treated at Veterans Affairs Hospitals in the USA.METHODS: We combined data from patients undergoing RP at six Veterans Affairs Medical Centers (West Los Angeles, San Diego, and Palo Alto, CA; Augusta, GA; and Durham and Asheville, NC) into the SEARCH database. Our exposure, body mass index (BMI) was abstracted from the medical records at the time of but prior to RP and categorized as normal weight (
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Vidal, A. C., Howard, L. E., Cooperberg, M. R., Kane, C. J., Aronson, W. J., Terris, M. K., Amling, C. L., Freedland, S. J. Tags: Epidemiology Source Type: research
Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis
Conclusions:
The combined analysis of bioinformatic data with computational modeling of ligand-receptor interactions demonstrated that enhancement of angiogenesis in prostate cancer metastases may occur through two different routes: elevation of VEGFA and reduction of class 3 Semaphorins. Therapeutic inhibition of angiogenesis in metastatic prostate cancer should account for both of these routes.
Source: BMC Systems Biology - September 4, 2015 Category: Molecular Biology Authors: R. BenderFeilim Mac Gabhann Source Type: research
Pathologic gleason 8‐10: do all men do poorly? results from the search database
ConclusionIn patients with high grade (Gleason 8‐10) prostate cancer after RP, the presence of either positive SM, ECE, or SVI are all associated with an increased risk of early BCR with 2‐year BCR risk of 50% or higher. On the contrary, men with organ‐confined margin‐negative disease have a very low risk of early BCR despite Gleason 8‐10 disease.This article is protected by copyright. All rights reserved.
Source: BJU International - September 9, 2015 Category: Urology & Nephrology Authors: Sean Fischer, Daniel Lin, Ross M. Simon, Lauren Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matt R. Cooperberg, Stephen J. Freedland, Adriana C. Vidal Tags: Original Article Source Type: research
Do all men with pathological Gleason score 8–10 prostate cancer have poor outcomes? Results from the SEARCH database
ConclusionsIn patients with high grade (Gleason score 8–10) prostate cancer after RP, the presence of either PSMs, ECE or SVI was associated with an increased risk of early BCR, with a 2‐year BCR risk of ≥50%. Conversely, men with organ‐confined margin‐negative disease had a very low risk of early BCR despite Gleason score 8–10 disease.
Source: BJU International - October 8, 2015 Category: Urology & Nephrology Authors: Sean Fischer, Daniel Lin, Ross M. Simon, Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matt R. Cooperberg, Stephen J. Freedland, Adriana C. Vidal Tags: Original Article Source Type: research
ABCDE Steps for Heart and Vascular Wellness Following a Prostate Cancer Diagnosis.
PMID: 26527696 [PubMed - in process]
Source: Circulation - November 3, 2015 Category: Cardiology Authors: Guan J, Khambhati J, Jones LW, Morgans A, Allaf M, Penson DF, Moslehi J Tags: Circulation Source Type: research
